Nonacog Alpha - an Efficient Therapeutic Option in Hemostase Management for Hemophilia Type B in Patients with Elective Arthropalsties

Badulescu, Oana Viola; Tudor, Razvan; Friedl, Wilhelm; Ciocoiu, Manuela; Sirbu, Paul Dan

Oana Viola Badulescu, Razvan Tudor, Wilhelm Friedl, Manuela Ciocoiu, Paul Dan Sirbu

Nonacog Alpha - an Efficient Therapeutic Option in Hemostase Management for Hemophilia Type B in Patients with Elective Arthropalsties

Abstract:

Hemophilia is a hereditary coagulopathy that is largely in the attention of developing countries, not because of its low incidence, but because of the high costs involved in the treatment of the disease and its disabling consequences of the disease, if treated inappropriately. The concentrates of coagulation factors currently available for the substitution treatment of hemophilic patients have undergone additional viral purification and inactivation techniques, in order to achieve a higher infectious safety, an aspect that also implies an increase in treatment costs for these patients. Currently, the major morbidity of patients with hemophilia is represented by the disabling articular pathology, secondary to repetitive bleeding episodes developed in the articular space. Although it has been proved that the prophylactic administration of coagulation factors helps to prevent joint disease in the case of patients that were not subject to prophylaxis, the repeated bleeding in the joints induces synovitis, which is irreversible and may progress despite subsequent prophylaxis. Under these conditions, total joint arthroplasty remains the only solution to reduce both, pain and subsequent bleeding episodes of hemophilic arthropathy. Effective hemostasis is a basic condition for successful interventions in hemophilic patients. In this regard, this paper aims to highlight the effectiveness of Nonacog Alpha, a product that contains recombinant factor IX, in the management of hemostasis, in the case of a patient with type B hemophilia, with indication of total endoprosthesis of the left hip.

Keywords:
hemophilia; Nonacog Alpha; hemarthrosis; total arthroplasty

Issue: 2018, Volume 69, Issue 7

Pages: 1911-1914

Publication date: 2018/8/15

https://doi.org/10.37358/RC.18.7.6444

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BADULESCU, O.V., TUDOR, R., FRIEDL, W., CIOCOIU, M., SIRBU, P.D., Nonacog Alpha - an Efficient Therapeutic Option in Hemostase Management for Hemophilia Type B in Patients with Elective Arthropalsties, Rev. Chim., 69(7), 2018, 1911-1914.

Vancouver
Badulescu OV, Tudor R, Friedl W, Ciocoiu M, Sirbu PD. Nonacog Alpha - an Efficient Therapeutic Option in Hemostase Management for Hemophilia Type B in Patients with Elective Arthropalsties. Rev. Chim.[internet]. 2018 Jul;69(7):1911-1914. Available from: https://doi.org/10.37358/RC.18.7.6444

APA 6th edition
Badulescu, O.V., Tudor, R., Friedl, W., Ciocoiu, M. & Sirbu, P.D. (2018). Nonacog Alpha - an Efficient Therapeutic Option in Hemostase Management for Hemophilia Type B in Patients with Elective Arthropalsties. Revista de Chimie, 69(7), 1911-1914. https://doi.org/10.37358/RC.18.7.6444

Harvard
Badulescu, O.V., Tudor, R., Friedl, W., Ciocoiu, M., Sirbu, P.D. (2018). 'Nonacog Alpha - an Efficient Therapeutic Option in Hemostase Management for Hemophilia Type B in Patients with Elective Arthropalsties', Revista de Chimie, 69(7), pp. 1911-1914. https://doi.org/10.37358/RC.18.7.6444

IEEE
O.V. Badulescu, R. Tudor, W. Friedl, M. Ciocoiu, P.D. Sirbu, "Nonacog Alpha - an Efficient Therapeutic Option in Hemostase Management for Hemophilia Type B in Patients with Elective Arthropalsties". Revista de Chimie, vol. 69, no. 7, pp. 1911-1914, 2018. [online]. https://doi.org/10.37358/RC.18.7.6444

Text
Oana Viola Badulescu, Razvan Tudor, Wilhelm Friedl, Manuela Ciocoiu, Paul Dan Sirbu,
Nonacog Alpha - an Efficient Therapeutic Option in Hemostase Management for Hemophilia Type B in Patients with Elective Arthropalsties,
Revista de Chimie,
Volume 69, Issue 7,
2018,
Pages 1911-1914,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.7.6444.
(https://revistadechimie.ro/Articles.asp?ID=6444)
Keywords: hemophilia; Nonacog Alpha; hemarthrosis; total arthroplasty

RIS
TY - JOUR
T1 - Nonacog Alpha - an Efficient Therapeutic Option in Hemostase Management for Hemophilia Type B in Patients with Elective Arthropalsties
A1 - Badulescu, Oana Viola
A2 - Tudor, Razvan
A3 - Friedl, Wilhelm
A4 - Ciocoiu, Manuela
A5 - Sirbu, Paul Dan
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 7
SP - 1911
EP - 1914
UR - https://doi.org/10.37358/RC.18.7.6444
KW - hemophilia
KW - Nonacog Alpha
KW - hemarthrosis
KW - total arthroplasty
ER -

BibTex
@article{RevCh2018P1911,
author = {Badulescu Oana Viola and Tudor Razvan and Friedl Wilhelm and Ciocoiu Manuela and Sirbu Paul Dan},
title = {Nonacog Alpha - an Efficient Therapeutic Option in Hemostase Management for Hemophilia Type B in Patients with Elective Arthropalsties},
journal = {Revista de Chimie},
volume = {69},
number = {7},
pages = {1911-1914},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.7.6444},
url = {https://revistadechimie.ro/Articles.asp?ID=6444}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)