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REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 8, 1987-1991

https://doi.org/10.37358/RC.18.8.6459

Serban Balanescu, Violeta Bojinca, Andra Balanescu, Mihai Bojinca

Lipoprotein (a) Biology and the Role in Cardiovascular Medicine

Abstract:

Lipoprotein (a) -Lp(a) - is an apoB-based plasma lipoprotein associated with major cardiovascular disease (CVD). Hepatocytes produce it with no clear physiological role. The liver also catabolizes it by means of the LDL receptor. Close structural resemblance with plasminogen may induce an unconfirmed increased risk for thrombosis, while growth factor-like activity may have pro-inflammatory effects. It promotes atherosclerosis and stimulates macrophages to transform to foam cells under the intima. There is a strong inherited -genetic influence on serum Lp(a) levels. Kringle IV type 2 single nucleotide polymorphisms and copy number variations are the major determinants of Lp(a) concentration and volume. Small molecular volume determined by apo(a) isoforms are the most pathogenic for CVD. Serum Lp(a) levels are remarkably constant with age. Multiple epidemiologic trials demonstrated a strong association between Lp(a) levels and cardiovascular disease, mainly coronary disease and ischemic stroke. No specific treatment to lower Lp(a) and consecutive reduction in CV risk is currently available. PCSK9 inhibitors and plasmapheresis have the most profound effect on Lp(a) serum concentration.
Keywords:
lipoproteins; cardiovascular disease; outcome

Issue: 2018, Volume 69, Issue 8
Pages: 1987-1991
Publication date: 2018/9/15
https://doi.org/10.37358/RC.18.8.6459
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
BALANESCU, S., BOJINCA, V., BALANESCU, A., BOJINCA, M., Lipoprotein (a) Biology and the Role in Cardiovascular Medicine, Rev. Chim., 69(8), 2018, 1987-1991.

Vancouver
Balanescu S, Bojinca V, Balanescu A, Bojinca M. Lipoprotein (a) Biology and the Role in Cardiovascular Medicine. Rev. Chim.[internet]. 2018 Aug;69(8):1987-1991. Available from: https://doi.org/10.37358/RC.18.8.6459


APA 6th edition
Balanescu, S., Bojinca, V., Balanescu, A. & Bojinca, M. (2018). Lipoprotein (a) Biology and the Role in Cardiovascular Medicine. Revista de Chimie, 69(8), 1987-1991. https://doi.org/10.37358/RC.18.8.6459


Harvard
Balanescu, S., Bojinca, V., Balanescu, A., Bojinca, M. (2018). 'Lipoprotein (a) Biology and the Role in Cardiovascular Medicine', Revista de Chimie, 69(8), pp. 1987-1991. https://doi.org/10.37358/RC.18.8.6459


IEEE
S. Balanescu, V. Bojinca, A. Balanescu, M. Bojinca, "Lipoprotein (a) Biology and the Role in Cardiovascular Medicine". Revista de Chimie, vol. 69, no. 8, pp. 1987-1991, 2018. [online]. https://doi.org/10.37358/RC.18.8.6459


Text
Serban Balanescu, Violeta Bojinca, Andra Balanescu, Mihai Bojinca,
Lipoprotein (a) Biology and the Role in Cardiovascular Medicine,
Revista de Chimie,
Volume 69, Issue 8,
2018,
Pages 1987-1991,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.8.6459.
(https://revistadechimie.ro/Articles.asp?ID=6459)
Keywords: lipoproteins; cardiovascular disease; outcome


RIS
TY - JOUR
T1 - Lipoprotein (a) Biology and the Role in Cardiovascular Medicine
A1 - Balanescu, Serban
A2 - Bojinca, Violeta
A3 - Balanescu, Andra
A4 - Bojinca, Mihai
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 8
SP - 1987
EP - 1991
UR - https://doi.org/10.37358/RC.18.8.6459
KW - lipoproteins
KW - cardiovascular disease
KW - outcome
ER -


BibTex
@article{RevCh2018P1987,
author = {Balanescu Serban and Bojinca Violeta and Balanescu Andra and Bojinca Mihai},
title = {Lipoprotein (a) Biology and the Role in Cardiovascular Medicine},
journal = {Revista de Chimie},
volume = {69},
number = {8},
pages = {1987-1991},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.8.6459},
url = {https://revistadechimie.ro/Articles.asp?ID=6459}
}
 
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