CORINA MARILENA CRISTACHE, EUGENIA EFTIMIE TOTU, DANIEL PETRE, ROXANA BUGA, GHEORGHE CRISTACHE, TIBERIU TOTU MELATONIN AND HYALURONIC ACID MIXTURE AS A POSSIBLE THERAPEUTIC AGENT IN DENTAL MEDICINE
The present work reports an efficient procedure for a simultaneous determination of melatonin (MEL) and hyaluronic acid (HA) mixture applying first derivative UV-Vis spectrophotometry. At selected wavelength (205 nm), the linearity range for each component of the mixture was established. The linear regression correlation coefficients for the direct UV-Vis spectra (RHA2 = 0.9627) and their first derivate (RHA2 = 0.9986) put in evidence a better fit for the derivative procedure. Through such simple analysis method, it was possible to emphasize that each component of MEL-HA mixture preserves its identity and characteristic properties. Consequently, the association of MEL and HA biomolecules could be used for obtaining a complex therapeutic agent with extensive applications in dental medicine.