Macro Creatine Kinase (macro CK) in Clinical Practice

Bojinca, Mihai; Bojinca, Violeta Claudia; Balanescu, Andra Rodica; Balanescu, Serban Mihai

Mihai Bojinca, Violeta Claudia Bojinca, Andra Rodica Balanescu, Serban Mihai Balanescu

Macro Creatine Kinase (macro CK) in Clinical Practice

Abstract:

Creatine kinase (CK) is an important enzyme involved in energy metabolism. CK is found in the cytosol and mitochondria of various tissues, mainly those with increased energy necessities as skeletal muscle, cardiac muscle and brain, but also in visceral tissues. CK is a dimeric molecule composed of two identical or different subunits, type M - muscular and type B - brain. The combination of M and B subunits leads to formation of three isozymes: CK - MM found mainly in the skeletal muscle, CK - BB found mainly in the brain and CK - MB found mainly in the cardiac muscle, but also in small quantities in the skeletal muscle. The serum increase of different isozymes of CK is a consequence of cell disruption in various clinical situations like physical training, rhabdomyolysis, myositis, muscular dystrophy, myocardial infarction and others, CK being an important biomarker for this diseases. Macro CK is a complex of CK and immunoglobulin (macro CK type 1) or a polymer of mitochondrial CK (macro CK type 2) that induces false and persistent elevation of CK levels that could mislead the clinician. We present a review of the literature concerning the appearance and clinical significance of macro CK.

Keywords:
creatine kinase; pathologies; outcome

Issue: 2018, Volume 69, Issue 8

Pages: 2107-2109

Publication date: 2018/9/15

https://doi.org/10.37358/RC.18.8.6483

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BOJINCA, M., BOJINCA, V.C., BALANESCU, A.R., BALANESCU, S.M., Macro Creatine Kinase (macro CK) in Clinical Practice, Rev. Chim., 69(8), 2018, 2107-2109.

Vancouver
Bojinca M, Bojinca VC, Balanescu AR, Balanescu SM. Macro Creatine Kinase (macro CK) in Clinical Practice. Rev. Chim.[internet]. 2018 Aug;69(8):2107-2109. Available from: https://doi.org/10.37358/RC.18.8.6483

APA 6th edition
Bojinca, M., Bojinca, V.C., Balanescu, A.R. & Balanescu, S.M. (2018). Macro Creatine Kinase (macro CK) in Clinical Practice. Revista de Chimie, 69(8), 2107-2109. https://doi.org/10.37358/RC.18.8.6483

Harvard
Bojinca, M., Bojinca, V.C., Balanescu, A.R., Balanescu, S.M. (2018). 'Macro Creatine Kinase (macro CK) in Clinical Practice', Revista de Chimie, 69(8), pp. 2107-2109. https://doi.org/10.37358/RC.18.8.6483

IEEE
M. Bojinca, V.C. Bojinca, A.R. Balanescu, S.M. Balanescu, "Macro Creatine Kinase (macro CK) in Clinical Practice". Revista de Chimie, vol. 69, no. 8, pp. 2107-2109, 2018. [online]. https://doi.org/10.37358/RC.18.8.6483

Text
Mihai Bojinca, Violeta Claudia Bojinca, Andra Rodica Balanescu, Serban Mihai Balanescu,
Macro Creatine Kinase (macro CK) in Clinical Practice,
Revista de Chimie,
Volume 69, Issue 8,
2018,
Pages 2107-2109,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.8.6483.
(https://revistadechimie.ro/Articles.asp?ID=6483)
Keywords: creatine kinase; pathologies; outcome

RIS
TY - JOUR
T1 - Macro Creatine Kinase (macro CK) in Clinical Practice
A1 - Bojinca, Mihai
A2 - Bojinca, Violeta Claudia
A3 - Balanescu, Andra Rodica
A4 - Balanescu, Serban Mihai
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 8
SP - 2107
EP - 2109
UR - https://doi.org/10.37358/RC.18.8.6483
KW - creatine kinase
KW - pathologies
KW - outcome
ER -

BibTex
@article{RevCh2018P2107,
author = {Bojinca Mihai and Bojinca Violeta Claudia and Balanescu Andra Rodica and Balanescu Serban Mihai},
title = {Macro Creatine Kinase (macro CK) in Clinical Practice},
journal = {Revista de Chimie},
volume = {69},
number = {8},
pages = {2107-2109},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.8.6483},
url = {https://revistadechimie.ro/Articles.asp?ID=6483}
}

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