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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 8, 2167-2171

https://doi.org/10.37358/RC.18.8.6492

Adrian Florin Spac, Alina Monica Miftode, Iuliean Vasile Asaftei, Ion Sandu

Quality by Design (QbD) Approach to Develop and Validate a HPLC Method for Piroxicam from Serum

Abstract:

Piroxicam belongs to the non-steroidal antiinflammatory class, it is utilized as analgesic, anti-inflammatory and antipyretic. A simple and accurate HPLC method was optimized and validated in the QbD approach, for the determination of piroxicam in serum. The optimization of HPLC analysis was performed using different columns, mobile phases and flows. The HPLC method was appropriately validated for linearity, limit of detection, limit of quantification, precision and accuracy in accordance with the ICH guidelines. The optimized and validated method proved to be simple, precise, and accurate, and can be successfully applied for the determination of piroxicam in serum.
Keywords:
piroxicam; QbD; HPLC; serum; validation

Issue: 2018, Volume 69, Issue 8
Pages: 2167-2171
Publication date: 2018/9/15
https://doi.org/10.37358/RC.18.8.6492
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
SPAC, A.F., MIFTODE, A.M., ASAFTEI, I.V., SANDU, I., Quality by Design (QbD) Approach to Develop and Validate a HPLC Method for Piroxicam from Serum, Rev. Chim., 69(8), 2018, 2167-2171.

Vancouver
Spac AF, Miftode AM, Asaftei IV, Sandu I. Quality by Design (QbD) Approach to Develop and Validate a HPLC Method for Piroxicam from Serum. Rev. Chim.[internet]. 2018 Aug;69(8):2167-2171. Available from: https://doi.org/10.37358/RC.18.8.6492


APA 6th edition
Spac, A.F., Miftode, A.M., Asaftei, I.V. & Sandu, I. (2018). Quality by Design (QbD) Approach to Develop and Validate a HPLC Method for Piroxicam from Serum. Revista de Chimie, 69(8), 2167-2171. https://doi.org/10.37358/RC.18.8.6492


Harvard
Spac, A.F., Miftode, A.M., Asaftei, I.V., Sandu, I. (2018). 'Quality by Design (QbD) Approach to Develop and Validate a HPLC Method for Piroxicam from Serum', Revista de Chimie, 69(8), pp. 2167-2171. https://doi.org/10.37358/RC.18.8.6492


IEEE
A.F. Spac, A.M. Miftode, I.V. Asaftei, I. Sandu, "Quality by Design (QbD) Approach to Develop and Validate a HPLC Method for Piroxicam from Serum". Revista de Chimie, vol. 69, no. 8, pp. 2167-2171, 2018. [online]. https://doi.org/10.37358/RC.18.8.6492


Text
Adrian Florin Spac, Alina Monica Miftode, Iuliean Vasile Asaftei, Ion Sandu,
Quality by Design (QbD) Approach to Develop and Validate a HPLC Method for Piroxicam from Serum,
Revista de Chimie,
Volume 69, Issue 8,
2018,
Pages 2167-2171,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.8.6492.
(https://revistadechimie.ro/Articles.asp?ID=6492)
Keywords: piroxicam; QbD; HPLC; serum; validation


RIS
TY - JOUR
T1 - Quality by Design (QbD) Approach to Develop and Validate a HPLC Method for Piroxicam from Serum
A1 - Spac, Adrian Florin
A2 - Miftode, Alina Monica
A3 - Asaftei, Iuliean Vasile
A4 - Sandu, Ion
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 8
SP - 2167
EP - 2171
UR - https://doi.org/10.37358/RC.18.8.6492
KW - piroxicam
KW - QbD
KW - HPLC
KW - serum
KW - validation
ER -


BibTex
@article{RevCh2018P2167,
author = {Spac Adrian Florin and Miftode Alina Monica and Asaftei Iuliean Vasile and Sandu Ion},
title = {Quality by Design (QbD) Approach to Develop and Validate a HPLC Method for Piroxicam from Serum},
journal = {Revista de Chimie},
volume = {69},
number = {8},
pages = {2167-2171},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.8.6492},
url = {https://revistadechimie.ro/Articles.asp?ID=6492}
}
 
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