Oxidative Stress Status in Patients with Choledocholithiasis: Before and After Endoscopic Sphincterotomy and Biliary Clearance

Sfarti, Catalin Victor; Ciobica, Alin; Stanciu, Carol; Balan, Gheorghe G.; Garleanu, Irina; Trifan, Anca

Catalin Victor Sfarti, Alin Ciobica, Carol Stanciu, Gheorghe G. Balan, Irina Garleanu, Anca Trifan

Oxidative Stress Status in Patients with Choledocholithiasis: Before and After Endoscopic Sphincterotomy and Biliary Clearance

Abstract:

Choledocholithiasis may cause biliary obstruction which leads to hepatocellular injury. Oxidative stress has been proposed as a possible mechanism involved in this disorder. This study evaluates the oxidative stress burden in patients with choledocholithiasis and secondary cholestasis, before and after endoscopic sphincterotomy. Experimental part: Patients diagnosed with choledocholithiasis and secondary extrahepatic cholestasis were included in the study between January 1st 2016 and October 31st 2016. In all patients oxidative stress markers were collected within 2 hours before and 48 hours after therapeutic ERCP. Selected markers were superoxide dismutase (SOD), glutathione peroxidase (GPX) and malondialdehyde (MDA). The results were compared to those from a group of 40 healthy subjects. Significantly lower concentrations of SOD (p = 0.03) and GPX (p [ 0.0001) activities, associated with an increased level of MDA level (p [ 0.0001) were shown in patients before biliary clearance compared with the healthy control group. After ERCP the only oxidative stress parameter which showed improvement was the SOD specific activity (p = 0.037). This study shows that extrahepatic cholestasis secondary to choledocholithiasis is associated with increased oxidative stress status. After biliary clearance one oxidative stress marker was significantly improved (SOD), suggesting a possible antioxidant effect of such procedure.

Keywords:
elderly; endoscopic retrograde cholangiopancreatography; superoxide dismutase; gallstones

Issue: 2018, Volume 69, Issue 8

Pages: 2172-2176

Publication date: 2018/9/15

https://doi.org/10.37358/RC.18.8.6493

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
SFARTI, C.V., CIOBICA, A., STANCIU, C., BALAN, G.G., GARLEANU, I., TRIFAN, A., Oxidative Stress Status in Patients with Choledocholithiasis: Before and After Endoscopic Sphincterotomy and Biliary Clearance, Rev. Chim., 69(8), 2018, 2172-2176.

Vancouver
Sfarti CV, Ciobica A, Stanciu C, Balan GG, Garleanu I, Trifan A. Oxidative Stress Status in Patients with Choledocholithiasis: Before and After Endoscopic Sphincterotomy and Biliary Clearance. Rev. Chim.[internet]. 2018 Aug;69(8):2172-2176. Available from: https://doi.org/10.37358/RC.18.8.6493

APA 6th edition
Sfarti, C.V., Ciobica, A., Stanciu, C., Balan, G.G., Garleanu, I. & Trifan, A. (2018). Oxidative Stress Status in Patients with Choledocholithiasis: Before and After Endoscopic Sphincterotomy and Biliary Clearance. Revista de Chimie, 69(8), 2172-2176. https://doi.org/10.37358/RC.18.8.6493

Harvard
Sfarti, C.V., Ciobica, A., Stanciu, C., Balan, G.G., Garleanu, I., Trifan, A. (2018). 'Oxidative Stress Status in Patients with Choledocholithiasis: Before and After Endoscopic Sphincterotomy and Biliary Clearance', Revista de Chimie, 69(8), pp. 2172-2176. https://doi.org/10.37358/RC.18.8.6493

IEEE
C.V. Sfarti, A. Ciobica, C. Stanciu, G.G. Balan, I. Garleanu, A. Trifan, "Oxidative Stress Status in Patients with Choledocholithiasis: Before and After Endoscopic Sphincterotomy and Biliary Clearance". Revista de Chimie, vol. 69, no. 8, pp. 2172-2176, 2018. [online]. https://doi.org/10.37358/RC.18.8.6493

Text
Catalin Victor Sfarti, Alin Ciobica, Carol Stanciu, Gheorghe G. Balan, Irina Garleanu, Anca Trifan,
Oxidative Stress Status in Patients with Choledocholithiasis: Before and After Endoscopic Sphincterotomy and Biliary Clearance,
Revista de Chimie,
Volume 69, Issue 8,
2018,
Pages 2172-2176,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.8.6493.
(https://revistadechimie.ro/Articles.asp?ID=6493)
Keywords: elderly; endoscopic retrograde cholangiopancreatography; superoxide dismutase; gallstones

RIS
TY - JOUR
T1 - Oxidative Stress Status in Patients with Choledocholithiasis: Before and After Endoscopic Sphincterotomy and Biliary Clearance
A1 - Sfarti, Catalin Victor
A2 - Ciobica, Alin
A3 - Stanciu, Carol
A4 - Balan, Gheorghe G.
A5 - Garleanu, Irina
A6 - Trifan, Anca
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 8
SP - 2172
EP - 2176
UR - https://doi.org/10.37358/RC.18.8.6493
KW - elderly
KW - endoscopic retrograde cholangiopancreatography
KW - superoxide dismutase
KW - gallstones
ER -

BibTex
@article{RevCh2018P2172,
author = {Sfarti Catalin Victor and Ciobica Alin and Stanciu Carol and Balan Gheorghe G. and Garleanu Irina and Trifan Anca},
title = {Oxidative Stress Status in Patients with Choledocholithiasis: Before and After Endoscopic Sphincterotomy and Biliary Clearance},
journal = {Revista de Chimie},
volume = {69},
number = {8},
pages = {2172-2176},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.8.6493},
url = {https://revistadechimie.ro/Articles.asp?ID=6493}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)