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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 8, 2254-2259

https://doi.org/10.37358/RC.18.8.6511

Irina Jari, Alexandru Naum, Liliana Gheorghe Moisii, Cipriana Stefanescu, Dragos Negru, Manuela Ursaru, Bogdan Mihnea Ciuntu, Daniel Timofte

Comparative Study by Analytical Multidisciplinary Methods and Oxidative Stress in Breast Cancer Diagnosis

Abstract:

To evaluate the diagnostic performance of mammography, elastography and breast magnetic resonance imaging (MRI), as tools for breast cancer diagnosis, against pathological diagnosis as the gold standard. Other risk factors such as obesity and oxidative stress are also disccused. In this comparison study, a total of 169 female patients (mean age 51 years, range 35-77 years) were enrolled between January 2016 and June 2017. After the physical examination of the breasts, patients were further randomized into three groups to mammography, elastography, or breast MRI. Only women with detected lesions classified into breast imaging and reporting data system (BI-RADS) category or Tsukuba elasticity score from 2 to 5 were included. Histopathology was used as the gold standard for diagnosis. The diagnostic performance of each modality was calculated. Of a total of 50 pathologically confirmed cancers, 25 were detected by mammography, 11 by elastography, and 14 by breast MRI, which resulted in sensitivities of 84% (PPV = 78%), 75% (PPV = 64%) and 86% (PPV = 75%), respectively. Mammography, elastography, and breast MRI led to 6, 5, and 4 false positive findings, which resulted in specificities of 86% (NPV = 90%), 87% (NPV = 92%) and 89% (NPV = 94%), respectively. The area under the curve (AUC) values for the mammography, elastography and breast MRI were 0.849 (95% CI, 0.758-0.939), 0.809 (95% CI, 0.670-0.948) and 0.876 (95% CI, 0.769-0.983). The DOR values were 32 (95% CI, 8-125), 20 (95% CI, 4-99) and 51 (95% CI, 8-315). The breast MRI proved a slight advantage over mammography as a diagnostic tool in breast cancer diagnosis.
Keywords:
breast elastography; breast MRI; diagnostic performance

Issue: 2018, Volume 69, Issue 8
Pages: 2254-2259
Publication date: 2018/9/15
https://doi.org/10.37358/RC.18.8.6511
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
JARI, I., NAUM, A., MOISII, L.G., STEFANESCU, C., NEGRU, D., URSARU, M., CIUNTU, B.M., TIMOFTE, D., Comparative Study by Analytical Multidisciplinary Methods and Oxidative Stress in Breast Cancer Diagnosis, Rev. Chim., 69(8), 2018, 2254-2259.

Vancouver
Jari I, Naum A, Moisii LG, Stefanescu C, Negru D, Ursaru M, Ciuntu BM, Timofte D. Comparative Study by Analytical Multidisciplinary Methods and Oxidative Stress in Breast Cancer Diagnosis. Rev. Chim.[internet]. 2018 Aug;69(8):2254-2259. Available from: https://doi.org/10.37358/RC.18.8.6511


APA 6th edition
Jari, I., Naum, A., Moisii, L.G., Stefanescu, C., Negru, D., Ursaru, M., Ciuntu, B.M. & Timofte, D. (2018). Comparative Study by Analytical Multidisciplinary Methods and Oxidative Stress in Breast Cancer Diagnosis. Revista de Chimie, 69(8), 2254-2259. https://doi.org/10.37358/RC.18.8.6511


Harvard
Jari, I., Naum, A., Moisii, L.G., Stefanescu, C., Negru, D., Ursaru, M., Ciuntu, B.M., Timofte, D. (2018). 'Comparative Study by Analytical Multidisciplinary Methods and Oxidative Stress in Breast Cancer Diagnosis', Revista de Chimie, 69(8), pp. 2254-2259. https://doi.org/10.37358/RC.18.8.6511


IEEE
I. Jari, A. Naum, L.G. Moisii, C. Stefanescu, D. Negru, M. Ursaru, B.M. Ciuntu, D. Timofte, "Comparative Study by Analytical Multidisciplinary Methods and Oxidative Stress in Breast Cancer Diagnosis". Revista de Chimie, vol. 69, no. 8, pp. 2254-2259, 2018. [online]. https://doi.org/10.37358/RC.18.8.6511


Text
Irina Jari, Alexandru Naum, Liliana Gheorghe Moisii, Cipriana Stefanescu, Dragos Negru, Manuela Ursaru, Bogdan Mihnea Ciuntu, Daniel Timofte,
Comparative Study by Analytical Multidisciplinary Methods and Oxidative Stress in Breast Cancer Diagnosis,
Revista de Chimie,
Volume 69, Issue 8,
2018,
Pages 2254-2259,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.8.6511.
(https://revistadechimie.ro/Articles.asp?ID=6511)
Keywords: breast elastography; breast MRI; diagnostic performance


RIS
TY - JOUR
T1 - Comparative Study by Analytical Multidisciplinary Methods and Oxidative Stress in Breast Cancer Diagnosis
A1 - Jari, Irina
A2 - Naum, Alexandru
A3 - Moisii, Liliana Gheorghe
A4 - Stefanescu, Cipriana
A5 - Negru, Dragos
A6 - Ursaru, Manuela
A7 - Ciuntu, Bogdan Mihnea
A8 - Timofte, Daniel
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 8
SP - 2254
EP - 2259
UR - https://doi.org/10.37358/RC.18.8.6511
KW - breast elastography; breast MRI; diagnostic performance
ER -


BibTex
@article{RevCh2018P2254,
author = {Jari Irina and Naum Alexandru and Moisii Liliana Gheorghe and Stefanescu Cipriana and Negru Dragos and Ursaru Manuela and Ciuntu Bogdan Mihnea and Timofte Daniel},
title = {Comparative Study by Analytical Multidisciplinary Methods and Oxidative Stress in Breast Cancer Diagnosis},
journal = {Revista de Chimie},
volume = {69},
number = {8},
pages = {2254-2259},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.8.6511},
url = {https://revistadechimie.ro/Articles.asp?ID=6511}
}
 
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