IRINA JARI, ALEXANDRU NAUM,LILIANA GHEORGHE MOISII, CIPRIANA STEFANESCU, DRAGOS NEGRU, MANUELA URSARU, BOGDAN MIHNEA CIUNTU, DANIEL TIMOFTE COMPARATIVE STUDY BY ANALYTICAL MULTIDISCIPLINARY METHODS AND OXIDATIVE STRESS IN BREAST CANCER DIAGNOSIS To evaluate the diagnostic performance of mammography, elastography and breast magnetic resonance imaging (MRI), as tools for breast cancer diagnosis, against pathological diagnosis as the gold standard. Other risk factors such as obesity and oxidative stress are also disccused. In this comparison study, a total of 169 female patients (mean age 51 years, range 35-77 years) were enrolled between January 2016 and June 2017. After the physical examination of the breasts, patients were further randomized into three groups to mammography, elastography, or breast MRI. Only women with detected lesions classified into breast imaging and reporting data system (BI-RADS) category or Tsukuba elasticity score from 2 to 5 were included. Histopathology was used as the gold standard for diagnosis. The diagnostic performance of each modality was calculated. Of a total of 50 pathologically confirmed cancers, 25 were detected by mammography, 11 by elastography, and 14 by breast MRI, which resulted in sensitivities of 84% (PPV = 78%), 75% (PPV = 64%) and 86% (PPV = 75%), respectively. Mammography, elastography, and breast MRI led to 6, 5, and 4 false positive findings, which resulted in specificities of 86% (NPV = 90%), 87% (NPV = 92%) and 89% (NPV = 94%), respectively. The area under the curve (AUC) values for the mammography, elastography and breast MRI were 0.849 (95% CI, 0.758-0.939), 0.809 (95% CI, 0.670-0.948) and 0.876 (95% CI, 0.769-0.983). The DOR values were 32 (95% CI, 8-125), 20 (95% CI, 4-99) and 51 (95% CI, 8-315). The breast MRI proved a slight advantage over mammography as a diagnostic tool in breast cancer diagnosis.
Keyword: breast elastography; breast MRI; diagnostic performance