RAMONA DANIELA PAVALOIU, FAWZIA SHA AT, CORINA BUBUEANU, GEORGETA NEAGU, ADRIAN ALBULESCU, CRISTINA HLEVCA, GHEORGHE NECHIFOR RELEASE OF POLYPHENOLS FROM LIPOSOMES LOADED WITH ECHINACEA PURPUREA The aim of this study was to develop a delivery system for polyphenols from an extract of Echinacea purpurea leaves, based on liposomes. Liposomes loaded with Echinacea purpurea were prepared and characterized in terms of entrapment efficiency, size, polydispersity index, stability and release behavior. Results showed good entrapment efficiency, small sizes, low polydispersity index and good stability over 90 days at 4oC. Also, the liposomal formulations presented reduced burst release and slow release of polyphenols compared with free extract. Therefore, liposomes offer a great potential in the development of drug delivery systems for polyphenols.
Keywords: polyphenols, Echinacea purpurea, liposomes, drug delivery systems