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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 9, 2351-2356

https://doi.org/10.37358/RC.18.9.6532

Angela Cozma, Adela Sitar Taut, Olga Orasan, Lucia Maria Procopciuc, Anca Daniela Farcas, Adina Stan, Vasile Negrean, Dorel Sampelean, Dana Pop, Dumitru Zdrenghea, Adriana Fodor

The Relationship Between eNOS (G894T ) Gene Polymorphism and Arterial Stiffness in Patients with Metabolic Syndrome

Abstract:

Metabolic syndrome (MS) is a clustering entity characterized by obesity, hypertension, hyperglycemia, dyslipidemia, and insulin resistance. Atherosclerotic lesions may be a complication of MS, arising from endothelial dysfunction and induced by decreased nitric oxide (NO) production. NO is synthesized by nitric oxide synthase (eNOS), encoded by the NOS3 gene, and displays anti-inflammatory, vasodilatory, and antiproliferative effects.We aimed to investigate the relationship between the G894T polymorphism of the eNOS gene and metabolic syndrome (including its components) and the association of this polymorphism with arterial function, assessed by determining pulse wave velocity and the augmentation index.The study included 100 consecutive patients, 55% with metabolic syndrome (based on IDF criteria -study group), 45% without MS (control group). Arterial stiffness was measured using TensioMedTMArteriograph. The presence of the homozygous (TT) or heterozygous (GT) state was associated, compared to subjects without the mutation (GG), with an increased prevalence of arterial hypertension, diabetes mellitus, with an increase of abdominal circumference, an increase of triglycerides, without significantly influencing the level of HDL. No significant differences were found between patients with G894T polymorphism compared to those without the mutation regarding the arterial stiffness. The eNOS gene polymorphism: 894G]T was significantly associated with the presence of MS; the polymorphism in homozygous and heterozygous state was associated with an increased risk of metabolic syndrome. G894T polymorphism did not significantly influence the values of the studied arterial parameters (pulse wave velocity, aortic and brachial augmentation index).
Keywords:
G894T polymorphism; arterial stiffness; metabolic syndrome

Issue: 2018, Volume 69, Issue 9
Pages: 2351-2356
Publication date: 2018/10/15
https://doi.org/10.37358/RC.18.9.6532
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
COZMA, A., TAUT, A.S., ORASAN, O., PROCOPCIUC, L.M., FARCAS, A.D., STAN, A., NEGREAN, V., SAMPELEAN, D., POP, D., ZDRENGHEA, D., FODOR, A., The Relationship Between eNOS (G894T ) Gene Polymorphism and Arterial Stiffness in Patients with Metabolic Syndrome, Rev. Chim., 69(9), 2018, 2351-2356.

Vancouver
Cozma A, Taut AS, Orasan O, Procopciuc LM, Farcas AD, Stan A, Negrean V, Sampelean D, Pop D, Zdrenghea D, Fodor A. The Relationship Between eNOS (G894T ) Gene Polymorphism and Arterial Stiffness in Patients with Metabolic Syndrome. Rev. Chim.[internet]. 2018 Sep;69(9):2351-2356. Available from: https://doi.org/10.37358/RC.18.9.6532


APA 6th edition
Cozma, A., Taut, A.S., Orasan, O., Procopciuc, L.M., Farcas, A.D., Stan, A.,... Fodor, A. (2018). The Relationship Between eNOS (G894T ) Gene Polymorphism and Arterial Stiffness in Patients with Metabolic Syndrome. Revista de Chimie, 69(9), 2351-2356. https://doi.org/10.37358/RC.18.9.6532


Harvard
Cozma, A., Taut, A.S., Orasan, O., Procopciuc, L.M., Farcas, A.D., Stan, A., Negrean, V., Sampelean, D., Pop, D., Zdrenghea, D., Fodor, A. (2018). 'The Relationship Between eNOS (G894T ) Gene Polymorphism and Arterial Stiffness in Patients with Metabolic Syndrome', Revista de Chimie, 69(9), pp. 2351-2356. https://doi.org/10.37358/RC.18.9.6532


IEEE
A. Cozma, A.S. Taut, O. Orasan, L.M. Procopciuc, A.D. Farcas, A. Stan, V. Negrean, D. Sampelean, D. Pop, D. Zdrenghea, A. Fodor, "The Relationship Between eNOS (G894T ) Gene Polymorphism and Arterial Stiffness in Patients with Metabolic Syndrome". Revista de Chimie, vol. 69, no. 9, pp. 2351-2356, 2018. [online]. https://doi.org/10.37358/RC.18.9.6532


Text
Angela Cozma, Adela Sitar Taut, Olga Orasan, Lucia Maria Procopciuc, Anca Daniela Farcas, Adina Stan, Vasile Negrean, Dorel Sampelean, Dana Pop, Dumitru Zdrenghea, Adriana Fodor,
The Relationship Between eNOS (G894T ) Gene Polymorphism and Arterial Stiffness in Patients with Metabolic Syndrome,
Revista de Chimie,
Volume 69, Issue 9,
2018,
Pages 2351-2356,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.9.6532.
(https://revistadechimie.ro/Articles.asp?ID=6532)
Keywords: G894T polymorphism; arterial stiffness; metabolic syndrome


RIS
TY - JOUR
T1 - The Relationship Between eNOS (G894T ) Gene Polymorphism and Arterial Stiffness in Patients with Metabolic Syndrome
A1 - Cozma, Angela
A2 - Taut, Adela Sitar
A3 - Orasan, Olga
A4 - Procopciuc, Lucia Maria
A5 - Farcas, Anca Daniela
A6 - Stan, Adina
A7 - Negrean, Vasile
A8 - Sampelean, Dorel
A9 - Pop, Dana
A10 - Zdrenghea, Dumitru
A11 - Fodor, Adriana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 9
SP - 2351
EP - 2356
UR - https://doi.org/10.37358/RC.18.9.6532
KW - G894T polymorphism
KW - arterial stiffness
KW - metabolic syndrome
ER -


BibTex
@article{RevCh2018P2351,
author = {Cozma Angela and Taut Adela Sitar and Orasan Olga and Procopciuc Lucia Maria and Farcas Anca Daniela and Stan Adina and Negrean Vasile and Sampelean Dorel and Pop Dana and Zdrenghea Dumitru and Fodor Adriana},
title = {The Relationship Between eNOS (G894T ) Gene Polymorphism and Arterial Stiffness in Patients with Metabolic Syndrome},
journal = {Revista de Chimie},
volume = {69},
number = {9},
pages = {2351-2356},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.9.6532},
url = {https://revistadechimie.ro/Articles.asp?ID=6532}
}
 
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