Pharmacological Effects of Natural Compounds Extracted from Urtica dioica Evaluated by in Silico and Experimental Methods

Seiman, Daniel Duda; Batalu, Alexandra; Seiman, Corina Duda; Ciopec, Mihaela; Udrea, Ana Maria; Motoc, Marilena; Negrea, Adina; Avram, Speranta

Daniel Duda Seiman, Alexandra Batalu, Corina Duda Seiman, Mihaela Ciopec, Ana Maria Udrea, Marilena Motoc, Adina Negrea, Speranta Avram

Pharmacological Effects of Natural Compounds Extracted from Urtica dioica Evaluated by in Silico and Experimental Methods

Abstract:

Urtica dioica is a perennial plant of the family of Urticaceae, originating in Eurasia. Nettle lives in temperate regions, prefers shady places, moist soil and rich in nutrients. Worldwide nettle is considered weed. Nettle was used in the past for its medicinal properties on the body and to cure diseases such as arthritis, rheumatism, urinary tract infections, kidney stones, gingivitis, hair loss, or ulcer. It is a plant rich in nutrients, with a high content of minerals and vitamins, especially vitamin A and C. The nettle has uses in both pharmaceutical and cosmetic and nutrition processes. Nettle extract contains ursolic acid and quercetin, giving the plant antioxidant and anti-aging effects. Studies on the nettle have demonstrated a multitude of pharmacological uses including: pharmacological, antiviral, antibacterial, hepato-protective, hypotensive, diuretic and anti-inflammatory effects. The methods of extraction of the compounds used in the plant were maceration and distillation using ethanol-water-soluble solvent, used because of its extraction capacity. At the same time, the metals in the nettle were determined taking 2 samples of the root, the stalk and the nettle leaves, but also the soil from which the plant grew and were analyzed by Spectroscopy Elemental Isotope Analysis using an X-ray Fluorescence (XRF) analyzer. By cheminformatics and bioinformatics tools we elucidate for first time: (i) the drug like features and bioavailability of ursolic acid and quercetin (ii) by predictive ADMET a set of pharmacokinetic features like: absorption, distribution, metabolized, blood brain barrier and nervous system barrier crossed and toxicology features (AMES, carcinogens, hepatotoxicity, Maximum tolerated dose (human)). Our results showed that quercetin is a good candidate as antioxidant and anti-aging effects.

Keywords:
Nettle; extraction; metal absorption; bioinformatics; pharmacological profiles

Issue: 2018, Volume 69, Issue 9

Pages: 2377-2381

Publication date: 2018/10/15

https://doi.org/10.37358/RC.18.9.6537

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
SEIMAN, D.D., BATALU, A., SEIMAN, C.D., CIOPEC, M., UDREA, A.M., MOTOC, M., NEGREA, A., AVRAM, S., Pharmacological Effects of Natural Compounds Extracted from Urtica dioica Evaluated by in Silico and Experimental Methods, Rev. Chim., 69(9), 2018, 2377-2381.

Vancouver
Seiman DD, Batalu A, Seiman CD, Ciopec M, Udrea AM, Motoc M, Negrea A, Avram S. Pharmacological Effects of Natural Compounds Extracted from Urtica dioica Evaluated by in Silico and Experimental Methods. Rev. Chim.[internet]. 2018 Sep;69(9):2377-2381. Available from: https://doi.org/10.37358/RC.18.9.6537

APA 6th edition
Seiman, D.D., Batalu, A., Seiman, C.D., Ciopec, M., Udrea, A.M., Motoc, M., Negrea, A. & Avram, S. (2018). Pharmacological Effects of Natural Compounds Extracted from Urtica dioica Evaluated by in Silico and Experimental Methods. Revista de Chimie, 69(9), 2377-2381. https://doi.org/10.37358/RC.18.9.6537

Harvard
Seiman, D.D., Batalu, A., Seiman, C.D., Ciopec, M., Udrea, A.M., Motoc, M., Negrea, A., Avram, S. (2018). 'Pharmacological Effects of Natural Compounds Extracted from Urtica dioica Evaluated by in Silico and Experimental Methods', Revista de Chimie, 69(9), pp. 2377-2381. https://doi.org/10.37358/RC.18.9.6537

IEEE
D.D. Seiman, A. Batalu, C.D. Seiman, M. Ciopec, A.M. Udrea, M. Motoc, A. Negrea, S. Avram, "Pharmacological Effects of Natural Compounds Extracted from Urtica dioica Evaluated by in Silico and Experimental Methods". Revista de Chimie, vol. 69, no. 9, pp. 2377-2381, 2018. [online]. https://doi.org/10.37358/RC.18.9.6537

Text
Daniel Duda Seiman, Alexandra Batalu, Corina Duda Seiman, Mihaela Ciopec, Ana Maria Udrea, Marilena Motoc, Adina Negrea, Speranta Avram,
Pharmacological Effects of Natural Compounds Extracted from Urtica dioica Evaluated by in Silico and Experimental Methods,
Revista de Chimie,
Volume 69, Issue 9,
2018,
Pages 2377-2381,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.9.6537.
(https://revistadechimie.ro/Articles.asp?ID=6537)
Keywords: Nettle; extraction; metal absorption; bioinformatics; pharmacological profiles

RIS
TY - JOUR
T1 - Pharmacological Effects of Natural Compounds Extracted from Urtica dioica Evaluated by in Silico and Experimental Methods
A1 - Seiman, Daniel Duda
A2 - Batalu, Alexandra
A3 - Seiman, Corina Duda
A4 - Ciopec, Mihaela
A5 - Udrea, Ana Maria
A6 - Motoc, Marilena
A7 - Negrea, Adina
A8 - Avram, Speranta
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 9
SP - 2377
EP - 2381
UR - https://doi.org/10.37358/RC.18.9.6537
KW - Nettle
KW - extraction
KW - metal absorption
KW - bioinformatics
KW - pharmacological profiles
ER -

BibTex
@article{RevCh2018P2377,
author = {Seiman Daniel Duda and Batalu Alexandra and Seiman Corina Duda and Ciopec Mihaela and Udrea Ana Maria and Motoc Marilena and Negrea Adina and Avram Speranta},
title = {Pharmacological Effects of Natural Compounds Extracted from Urtica dioica Evaluated by in Silico and Experimental Methods},
journal = {Revista de Chimie},
volume = {69},
number = {9},
pages = {2377-2381},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.9.6537},
url = {https://revistadechimie.ro/Articles.asp?ID=6537}
}

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