PATRICIA NICOLA, ELENA ARDELEANU, CARMEN GADAU, MARIA DOROBANTU, ROXANA DARABONT, IOAN TILEA, ANDREEA VARGA, ROXANA FOLESCU, ALEXANDRA SIMONA ZAMFIR, MIHAELA BOANCA, LILIANA STRAT, TEIM BAAJ, DANIELA GURGUS EVALUATION OF BIOCHEMICAL AND CLINICAL PARAMETERS OF HYPERTENSION WITH TYPE 2 DIABETES MELLITUS The aim of this study was to assess the basic biochemical and clinical characteristics of patients with hypertension and type 2 diabetes mellitus (T2DM), office blood pressure (BP) and 24-h BP profile, their risk factors and associated comorbidities. Compared with non-diabetics, hypertensive patients with T2DM were older, with a longer duration of hypertension (5.9 vs. 4.7 years), greater office blood pressure and ambulatory BP values, increased incidence of multiple risk factors, target organ damage and cardiovascular disease. Biochemical data in hypertension with T2DM revealed significantly high levels of LDL cholesterol, triglycerides, creatinine, micro- and macro-albuminuria and a reduced estimated glomerular filtration rate. The presence of diabetes was associated with obesity, represented by a BMI >30 kg/m2 (OR 2.08 <95% CI 1.26-3.45>, p = 0.004), abdominal obesity (OR 1.85 <95% CI 1.11-3.04>, p = 0.016), high LDL cholesterol (OR 2.02 <95% CI 1.22-3.35>, p = 0.006) and high triglycerides (OR 1.86 <95% CI 1.11-3.11>, p = 0.017).
Keywords: Hypertension, type 2 diabetes, clinical and biochemical characteristics