Flow Cytometry With Inflorescence-An Accessible Method in the Study of Qualitative and Quantitative Modifications of Blood Platelets in Immune Thrombocytopenic Purpura

Badulescu, Oana Viola; Badescu, Magda; Ciocoiu, Manuela; Mocanu, Madalina

Oana Viola Badulescu, Magda Badescu, Manuela Ciocoiu, Madalina Mocanu

Flow Cytometry With Inflorescence-An Accessible Method in the Study of Qualitative and Quantitative Modifications of Blood Platelets in Immune Thrombocytopenic Purpura

Abstract:

The immune thrombocytopenic purpura (ITP) is a polymorphic and hematologic pathology, in terms of both clinical manifestations and etiopathogenic mechanisms, which bring on this disease. Establishing the type of thrombocytopenia, which can either be primary or secondary, peripheral or central, is essential for a further proper therapeutic conduct. The current means of diagnosis include a large variety of hematologic, immunologic and biochemical explorations, from the traditional ones to the latest methods, either genetical or molecular. The purpose of this paper is to emphasize the importance of a classical method of diagnosis, used in the primary triage of patients suffering from thrombocytopenia, highly valuable in the diagnosis process: the analysis of the mean platelet volume (MPV) and of the platelet distribution width (PDW), parameters revealed by the CBC (complete blood count). Evaluating the size of the platelets is a useful tool in the differential diagnosis between immune thrombocytopenic purpura and hereditary macrothrombocytopenia. The platelet distribution width and the mean platelet volume are read simultaneously, in order to differentiate the immune peripheral thrombocytopenia from the central one. The classical, viable and accessible method facilitates the measurement of MPV and PDW with the automatic analyzer, which functions according to the principle of flow cytometry with inflorescence, by using a LASER semiconductor and hydrodynamic focusing.

Keywords:
immune thrombocytopenic purpura; platelet volume; platelet distribution width; flow cytometry

Issue: 2018, Volume 69, Issue 9

Pages: 2476-2478

Publication date: 2018/10/15

https://doi.org/10.37358/RC.18.9.6557

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BADULESCU, O.V., BADESCU, M., CIOCOIU, M., MOCANU, M., Flow Cytometry With Inflorescence-An Accessible Method in the Study of Qualitative and Quantitative Modifications of Blood Platelets in Immune Thrombocytopenic Purpura, Rev. Chim., 69(9), 2018, 2476-2478.

Vancouver
Badulescu OV, Badescu M, Ciocoiu M, Mocanu M. Flow Cytometry With Inflorescence-An Accessible Method in the Study of Qualitative and Quantitative Modifications of Blood Platelets in Immune Thrombocytopenic Purpura. Rev. Chim.[internet]. 2018 Sep;69(9):2476-2478. Available from: https://doi.org/10.37358/RC.18.9.6557

APA 6th edition
Badulescu, O.V., Badescu, M., Ciocoiu, M. & Mocanu, M. (2018). Flow Cytometry With Inflorescence-An Accessible Method in the Study of Qualitative and Quantitative Modifications of Blood Platelets in Immune Thrombocytopenic Purpura. Revista de Chimie, 69(9), 2476-2478. https://doi.org/10.37358/RC.18.9.6557

Harvard
Badulescu, O.V., Badescu, M., Ciocoiu, M., Mocanu, M. (2018). 'Flow Cytometry With Inflorescence-An Accessible Method in the Study of Qualitative and Quantitative Modifications of Blood Platelets in Immune Thrombocytopenic Purpura', Revista de Chimie, 69(9), pp. 2476-2478. https://doi.org/10.37358/RC.18.9.6557

IEEE
O.V. Badulescu, M. Badescu, M. Ciocoiu, M. Mocanu, "Flow Cytometry With Inflorescence-An Accessible Method in the Study of Qualitative and Quantitative Modifications of Blood Platelets in Immune Thrombocytopenic Purpura". Revista de Chimie, vol. 69, no. 9, pp. 2476-2478, 2018. [online]. https://doi.org/10.37358/RC.18.9.6557

Text
Oana Viola Badulescu, Magda Badescu, Manuela Ciocoiu, Madalina Mocanu,
Flow Cytometry With Inflorescence-An Accessible Method in the Study of Qualitative and Quantitative Modifications of Blood Platelets in Immune Thrombocytopenic Purpura,
Revista de Chimie,
Volume 69, Issue 9,
2018,
Pages 2476-2478,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.9.6557.
(https://revistadechimie.ro/Articles.asp?ID=6557)
Keywords: immune thrombocytopenic purpura; platelet volume; platelet distribution width; flow cytometry

RIS
TY - JOUR
T1 - Flow Cytometry With Inflorescence-An Accessible Method in the Study of Qualitative and Quantitative Modifications of Blood Platelets in Immune Thrombocytopenic Purpura
A1 - Badulescu, Oana Viola
A2 - Badescu, Magda
A3 - Ciocoiu, Manuela
A4 - Mocanu, Madalina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 9
SP - 2476
EP - 2478
UR - https://doi.org/10.37358/RC.18.9.6557
KW - immune thrombocytopenic purpura
KW - platelet volume
KW - platelet distribution width
KW - flow cytometry
ER -

BibTex
@article{RevCh2018P2476,
author = {Badulescu Oana Viola and Badescu Magda and Ciocoiu Manuela and Mocanu Madalina},
title = {Flow Cytometry With Inflorescence-An Accessible Method in the Study of Qualitative and Quantitative Modifications of Blood Platelets in Immune Thrombocytopenic Purpura},
journal = {Revista de Chimie},
volume = {69},
number = {9},
pages = {2476-2478},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.9.6557},
url = {https://revistadechimie.ro/Articles.asp?ID=6557}
}

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