The Impact of Proinflammatory Cytokynes of Rheumatoid Polyarthritis on the Generalized Loss of Bone Mass

Barzoi, Raluca; Rezus, Elena; Badescu, Codruta; Namat, Razan Al; Ciocoiu, Manuela

Raluca Barzoi, Elena Rezus, Codruta Badescu, Razan Al Namat, Manuela Ciocoiu

The Impact of Proinflammatory Cytokynes of Rheumatoid Polyarthritis on the Generalized Loss of Bone Mass

Abstract:

There is a bidirectional interaction between most immune cells and osteoblasts, osteoclasts and their precursor cells. The receptor activator of nuclear factor-kB ligand (RANKL)/RANK/osteoprotegerin (OPG) system plays an essential role in the formation of osteoblasts, but it also has implications in osteoclast biology and implicitly on the diseases characterized by bone loss. Proinflammatory cytokines existing at synovial level function as direct or indirect stimulators of osteoclast differentiation, but also of its survival or activity, although some cytokines may also play an antiosteocastogenic role. The fate of bone destruction is determined by the balance between osteoclastogenic and antiosteoclastogenic mediators. Our study has shown that the early initiation of the therapy with anti-TNF and anti-IL6 biological agents, in patients with rheumatoid arthritis, inhibits bone destruction, regardless of the anti-inflammatory activity in patients with rheumatoid arthritis.

Keywords:
rheumatoid arthritis; systemic osteoporosis; proinflammatory cytokines; RANKL/RANK/OPG

Issue: 2018, Volume 69, Issue 9

Pages: 2541-2545

Publication date: 2018/10/15

https://doi.org/10.37358/RC.18.9.6572

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BARZOI, R., REZUS, E., BADESCU, C., NAMAT, R.A., CIOCOIU, M., The Impact of Proinflammatory Cytokynes of Rheumatoid Polyarthritis on the Generalized Loss of Bone Mass, Rev. Chim., 69(9), 2018, 2541-2545.

Vancouver
Barzoi R, Rezus E, Badescu C, Namat RA, Ciocoiu M. The Impact of Proinflammatory Cytokynes of Rheumatoid Polyarthritis on the Generalized Loss of Bone Mass. Rev. Chim.[internet]. 2018 Sep;69(9):2541-2545. Available from: https://doi.org/10.37358/RC.18.9.6572

APA 6th edition
Barzoi, R., Rezus, E., Badescu, C., Namat, R.A. & Ciocoiu, M. (2018). The Impact of Proinflammatory Cytokynes of Rheumatoid Polyarthritis on the Generalized Loss of Bone Mass. Revista de Chimie, 69(9), 2541-2545. https://doi.org/10.37358/RC.18.9.6572

Harvard
Barzoi, R., Rezus, E., Badescu, C., Namat, R.A., Ciocoiu, M. (2018). 'The Impact of Proinflammatory Cytokynes of Rheumatoid Polyarthritis on the Generalized Loss of Bone Mass', Revista de Chimie, 69(9), pp. 2541-2545. https://doi.org/10.37358/RC.18.9.6572

IEEE
R. Barzoi, E. Rezus, C. Badescu, R.A. Namat, M. Ciocoiu, "The Impact of Proinflammatory Cytokynes of Rheumatoid Polyarthritis on the Generalized Loss of Bone Mass". Revista de Chimie, vol. 69, no. 9, pp. 2541-2545, 2018. [online]. https://doi.org/10.37358/RC.18.9.6572

Text
Raluca Barzoi, Elena Rezus, Codruta Badescu, Razan Al Namat, Manuela Ciocoiu,
The Impact of Proinflammatory Cytokynes of Rheumatoid Polyarthritis on the Generalized Loss of Bone Mass,
Revista de Chimie,
Volume 69, Issue 9,
2018,
Pages 2541-2545,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.9.6572.
(https://revistadechimie.ro/Articles.asp?ID=6572)
Keywords: rheumatoid arthritis; systemic osteoporosis; proinflammatory cytokines; RANKL/RANK/OPG

RIS
TY - JOUR
T1 - The Impact of Proinflammatory Cytokynes of Rheumatoid Polyarthritis on the Generalized Loss of Bone Mass
A1 - Barzoi, Raluca
A2 - Rezus, Elena
A3 - Badescu, Codruta
A4 - Namat, Razan Al
A5 - Ciocoiu, Manuela
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 9
SP - 2541
EP - 2545
UR - https://doi.org/10.37358/RC.18.9.6572
KW - rheumatoid arthritis
KW - systemic osteoporosis
KW - proinflammatory cytokines
KW - RANKL/RANK/OPG
ER -

BibTex
@article{RevCh2018P2541,
author = {Barzoi Raluca and Rezus Elena and Badescu Codruta and Namat Razan Al and Ciocoiu Manuela},
title = {The Impact of Proinflammatory Cytokynes of Rheumatoid Polyarthritis on the Generalized Loss of Bone Mass},
journal = {Revista de Chimie},
volume = {69},
number = {9},
pages = {2541-2545},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.9.6572},
url = {https://revistadechimie.ro/Articles.asp?ID=6572}
}

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