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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 10, 2638-2641

https://doi.org/10.37358/RC.18.10.6596

Simina Boia, Eugen Radu Boia, Raluca Amalia Ceausu, Constantin Nicolae Balica, Ovidiu Alexandru Mederle

HPV18 Associated with E-cadherin Expression in Head and Neck Squamous Cell Carcinoma

Abstract:

HPV is an important oropharyngeal cancer cause, but it may have a role in other head and neck cancers? HPVpositive head and neck squamous cell carcinoma (HNSCC) epithelial-mesenchymal transition role is unclear. We included 38 cases: 20 laryngeal, 3 corresponding lymph nodes; 5 oropharyngeal, 5 hypopharyngeal, 2 rhynopahryngeal, 2 pharyngolaryngeal and 1 naso-sinusal case. Immunoreactivity was positive in nuclear expression cells, accordingly: score 1 (10-30%), 2 (30-50%) and 3 (]50%). HPV18 immunoexpression appeared in 18 cases (47.36%), (11 laryngeal, 4 oropharyngeal, 1 hypopharyngeal, 1 pharyngolaryngeal and 1 naso-sinusal). The score was 1 in larynx well differentiated type. The score was between 1 and 3 in larynx moderately differentiated types, and a significant correlation HPV18/E-cadherin was found (p=0.031). HPV18+/E-cadherin low values were noticed in larynx, oropharynx, pharyngo-larynx and naso-sinusal well and moderately differentiated types. HPV18-/E-cadherin low values were present in larynx, hypo and rhyno-pharynx moderately and poorly differentiated and larynx well differentiated types. Larynx presented HPV18/E-cadherin and moderately differentiated type significant correlation. Rhyno, hypo-pharyngeal and laryngeal presented HPV18-/E-cadherin low values association for moderately, poorly and undifferentiated types. The oropharyngeal location was associated with E-cadherin maximum values, independently of HPV18 status.
Keywords:
HPV18; head and neck squamous cell carcinoma; mesenchymal epithelial transition

Issue: 2018, Volume 69, Issue 10
Pages: 2638-2641
Publication date: 2018/11/15
https://doi.org/10.37358/RC.18.10.6596
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
BOIA, S., BOIA, E.R., CEAUSU, R.A., BALICA, C.N., MEDERLE, O.A., HPV18 Associated with E-cadherin Expression in Head and Neck Squamous Cell Carcinoma, Rev. Chim., 69(10), 2018, 2638-2641.

Vancouver
Boia S, Boia ER, Ceausu RA, Balica CN, Mederle OA. HPV18 Associated with E-cadherin Expression in Head and Neck Squamous Cell Carcinoma. Rev. Chim.[internet]. 2018 Oct;69(10):2638-2641. Available from: https://doi.org/10.37358/RC.18.10.6596


APA 6th edition
Boia, S., Boia, E.R., Ceausu, R.A., Balica, C.N. & Mederle, O.A. (2018). HPV18 Associated with E-cadherin Expression in Head and Neck Squamous Cell Carcinoma. Revista de Chimie, 69(10), 2638-2641. https://doi.org/10.37358/RC.18.10.6596


Harvard
Boia, S., Boia, E.R., Ceausu, R.A., Balica, C.N., Mederle, O.A. (2018). 'HPV18 Associated with E-cadherin Expression in Head and Neck Squamous Cell Carcinoma', Revista de Chimie, 69(10), pp. 2638-2641. https://doi.org/10.37358/RC.18.10.6596


IEEE
S. Boia, E.R. Boia, R.A. Ceausu, C.N. Balica, O.A. Mederle, "HPV18 Associated with E-cadherin Expression in Head and Neck Squamous Cell Carcinoma". Revista de Chimie, vol. 69, no. 10, pp. 2638-2641, 2018. [online]. https://doi.org/10.37358/RC.18.10.6596


Text
Simina Boia, Eugen Radu Boia, Raluca Amalia Ceausu, Constantin Nicolae Balica, Ovidiu Alexandru Mederle,
HPV18 Associated with E-cadherin Expression in Head and Neck Squamous Cell Carcinoma,
Revista de Chimie,
Volume 69, Issue 10,
2018,
Pages 2638-2641,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.10.6596.
(https://revistadechimie.ro/Articles.asp?ID=6596)
Keywords: HPV18; head and neck squamous cell carcinoma; mesenchymal epithelial transition


RIS
TY - JOUR
T1 - HPV18 Associated with E-cadherin Expression in Head and Neck Squamous Cell Carcinoma
A1 - Boia, Simina
A2 - Boia, Eugen Radu
A3 - Ceausu, Raluca Amalia
A4 - Balica, Constantin Nicolae
A5 - Mederle, Ovidiu Alexandru
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 10
SP - 2638
EP - 2641
UR - https://doi.org/10.37358/RC.18.10.6596
KW - HPV18
KW - head and neck squamous cell carcinoma
KW - mesenchymal epithelial transition
ER -


BibTex
@article{RevCh2018P2638,
author = {Boia Simina and Boia Eugen Radu and Ceausu Raluca Amalia and Balica Constantin Nicolae and Mederle Ovidiu Alexandru},
title = {HPV18 Associated with E-cadherin Expression in Head and Neck Squamous Cell Carcinoma},
journal = {Revista de Chimie},
volume = {69},
number = {10},
pages = {2638-2641},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.10.6596},
url = {https://revistadechimie.ro/Articles.asp?ID=6596}
}
 
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