RAZAN AL NAMAT, MAURA GABRIELA FELEA, IRINA IULIANA COSTACHE, VIVIANA AURSULESEI, ANTONIU PETRIS, OVIDIU MITU, MIHAI CONSTANTIN, VICTORITA SORODOC, LAURENTIU SORODOC, IONELA LARISA MIFTODE, RADU MIFTODE, NADIA AL NAMAT, DINA AL NAMAT, ANDREEA LUTA, ADRIANA ION, MIRELA MIHAELA MIHALCIA, MANUELA CIOCOIU, GRIGORE TINICA, FLORIN MITU HEART-TYPE FATTY ACID-BINDING PROTEIN (H-FABP) IN PATIENTS WITH TYPE 2 DIABETES BENEFICIARIES OF REHABILITATION PROGRAM POST CORONARY ARTERY BYPASS GRAFTING Heart-type fatty acid-binding protein (H-FABP) is a non-invasive bio-marker, with high sensitivity and specificity, being capable to point out the myocardial injury and to predict major adverse cardiovascular events (MACE). Cardiac rehabilitation program, through a complex and sustained post-interventional management plays an important role in reducing the plasma levels of H-FABP. In the study, which included 120 post-coronary artery bypass (CABG) patients, we analyzed the link between low levels of general post-surgical health status and the presence of cardiovascular risk factors, common biochemical markers, and especially the role played by diabetic status in lowering the plasma H-FABP levels. From the group, 65 patients had been diagnosed with type 2 Diabetes Mellitus (T2DM). The H-FABP values decreased both in diabetics and in non-diabetics between the two phases of CR, 6 months away from CABG. More than half of the patients had important reduction of H-FABP, at 6 months after the onset of CR program. Half of the group registered a smaller reduction of H-FABP, but more noticeable in diabetics. Ischemic lesion during open heart surgery is linked to high levels of H-FABP and with an occurence risk of postoperative atrial fibrillation, that can be also triggered and sustained by multiple endocrine conditions related to aging. Thus, metabolic control should always remain a target of the complex management in cardiac rehabilitation.