VICTOR DANIEL MIRON, ANCA CRISTINA DRAGANESCU, OANA SANDULESCU, CONSTANTA ANGELICA VISAN, MARIA MADALINA MERISESCU, ANCA STREINU CERCEL, DANIELA PITIGOI, ALEXANDRU RAFILA, OLGA MIHAELA DOROBAT, GHEORGHITA JUGULETE, ADRIAN STREINU CERCEL, SILVIA STOICESCU, MONICA LUMINITA LUMINOS PNEUMOCOCCAL COLONIZATION AND PNEUMOCOCCAL DISEASE IN CHILDREN WITH INFLUENZA CLINICAL, LABORATORY AND EPIDEMIOLOGICAL FEATURES We retrospectively studied clinical features of the 2015-2016 paediatric influenza season and the rate of pneumococcal colonization/disease in a reference Romanian infectious diseases institute. Peak influenza activity occurred between weeks 5-10/2016; A viruses initially predominated, switching to B viruses after week 12/2016. Patients’ median age was 4.4 years. Patients with influenza A were significantly younger compared with influenza B (p<0.001), and required longer hospitalization (p<0.001). S. pneumoniae was identified in 5.4% of cases (only influenza A), accounting for 2.1% pneumococcal disease and 3.3% pneumococcal colonization. Patients with S. pneumoniae were younger compared to negative cases (p=0.164), presented to the hospital later (p=0.049), had higher erythrocyte sedimentation rate (ESR, p=0.008), and prolonged hospitalization (p=0.016), regardless of whether the strains caused disease or were colonizers. Commonly used inflammation markers may identify the presence of pneumococci (ESR, p=0.008) or differentiate between colonization and disease (neutrophil count, p=0.011) in children with influenza A.