LUCRETIU RADU, MARA CARSOTE, ANCUTA AUGUSTINA GHEORGHISAN GALATEANU, SMARANDA ADELINA PREDA, VERONICA CALBOREAN, RADU STANESCU, VICTOR GHEORMAN, DANA MARIA ALBULESCU BLOOD PARATHYRIN AND MINERAL METABOLISM DYNAMICS A CLINICAL ANALYZE Circulating parathyrin (PTH or parthormon) is increased in primary hyperparathyroidism (PHP) in association with high total/ionic calcium (T/I Ca) and others mineral metabolism anomalies. This is a clinical cross-sectional and case-control study analyzing these changes after PHP surgical correction in menopausal women. Baseline parameters were: mean age at diagnosis (59.63±9.6 years), TCa of 10.9±0.7 mg/dL, PTH of 138.02±59.36 pg/mL. Longitudinal data showed: final TCa p<0.00001, ICa p<0.00001, phosphorus p<0.0001, magnesium p=0.9, 24-h urinary calcium p=0.4, 25-hydroxycholecalciferol p=0.01, PTH p<0.00001. High circulating parathyrin values due to PHP normalized after surgery in addition to statistical significant changes of TCa, ICa, P, lumbar Bone Mineral Density provided by Dual-Energy X-Ray Absorptiometry; Mg and 24-h Ca might not be a marker of general mineral metabolism improvement.