Comparative Study of Drug Interactions in Benzodiazepine Associated Deaths

Chitescu, Carmen Lidia; Lisa, Elena Lacramioara; Fulga, Iuliu; Paltenea, Elpida; Moraru, Monica; Georgescu, Costinela Valerica; Vasile, Ionut Claudiu

Carmen Lidia Chitescu, Elena Lacramioara Lisa, Iuliu Fulga, Elpida Paltenea, Monica Moraru, Costinela Valerica Georgescu, Ionut Claudiu Vasile

Comparative Study of Drug Interactions in Benzodiazepine Associated Deaths

Abstract:

Due to their widespread use and availability, benzodiazepines are one of the most common classes of drug associated with both unintentional and suicidal drug deaths. The presented work, conducted at the Legal Medicine Service of Galati aims to expound the role of pharmaco-toxicological interactions between benzodiazepines and other psychoactive substances in drug related deaths. A retrospective analysis of 13 cases of fatal substances overdose was done. Parent drugs and metabolites detection and quantification in postmortem specimens were performed by HPLC-DAD, as part of a full forensic autopsy. The substance interactions were investigated and interpreted in the context of the available medical history. The study results emphases the acute toxicity of a given drug /alcohol combination.

Keywords:
benzodiazepines; drug interactions; toxicology; HPLC analysis

Issue: 2018, Volume 69, Issue 10

Pages: 2768-2775

Publication date: 2018/11/15

https://doi.org/10.37358/RC.18.10.6622

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
CHITESCU, C.L., LISA, E.L., FULGA, I., PALTENEA, E., MORARU, M., GEORGESCU, C.V., VASILE, I.C., Comparative Study of Drug Interactions in Benzodiazepine Associated Deaths, Rev. Chim., 69(10), 2018, 2768-2775.

Vancouver
Chitescu CL, Lisa EL, Fulga I, Paltenea E, Moraru M, Georgescu CV, Vasile IC. Comparative Study of Drug Interactions in Benzodiazepine Associated Deaths. Rev. Chim.[internet]. 2018 Oct;69(10):2768-2775. Available from: https://doi.org/10.37358/RC.18.10.6622

APA 6th edition
Chitescu, C.L., Lisa, E.L., Fulga, I., Paltenea, E., Moraru, M., Georgescu, C.V. & Vasile, I.C. (2018). Comparative Study of Drug Interactions in Benzodiazepine Associated Deaths. Revista de Chimie, 69(10), 2768-2775. https://doi.org/10.37358/RC.18.10.6622

Harvard
Chitescu, C.L., Lisa, E.L., Fulga, I., Paltenea, E., Moraru, M., Georgescu, C.V., Vasile, I.C. (2018). 'Comparative Study of Drug Interactions in Benzodiazepine Associated Deaths', Revista de Chimie, 69(10), pp. 2768-2775. https://doi.org/10.37358/RC.18.10.6622

IEEE
C.L. Chitescu, E.L. Lisa, I. Fulga, E. Paltenea, M. Moraru, C.V. Georgescu, I.C. Vasile, "Comparative Study of Drug Interactions in Benzodiazepine Associated Deaths". Revista de Chimie, vol. 69, no. 10, pp. 2768-2775, 2018. [online]. https://doi.org/10.37358/RC.18.10.6622

Text
Carmen Lidia Chitescu, Elena Lacramioara Lisa, Iuliu Fulga, Elpida Paltenea, Monica Moraru, Costinela Valerica Georgescu, Ionut Claudiu Vasile,
Comparative Study of Drug Interactions in Benzodiazepine Associated Deaths,
Revista de Chimie,
Volume 69, Issue 10,
2018,
Pages 2768-2775,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.10.6622.
(https://revistadechimie.ro/Articles.asp?ID=6622)
Keywords: benzodiazepines; drug interactions; toxicology; HPLC analysis

RIS
TY - JOUR
T1 - Comparative Study of Drug Interactions in Benzodiazepine Associated Deaths
A1 - Chitescu, Carmen Lidia
A2 - Lisa, Elena Lacramioara
A3 - Fulga, Iuliu
A4 - Paltenea, Elpida
A5 - Moraru, Monica
A6 - Georgescu, Costinela Valerica
A7 - Vasile, Ionut Claudiu
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 10
SP - 2768
EP - 2775
UR - https://doi.org/10.37358/RC.18.10.6622
KW - benzodiazepines
KW - drug interactions
KW - toxicology
KW - HPLC analysis
ER -

BibTex
@article{RevCh2018P2768,
author = {Chitescu Carmen Lidia and Lisa Elena Lacramioara and Fulga Iuliu and Paltenea Elpida and Moraru Monica and Georgescu Costinela Valerica and Vasile Ionut Claudiu},
title = {Comparative Study of Drug Interactions in Benzodiazepine Associated Deaths},
journal = {Revista de Chimie},
volume = {69},
number = {10},
pages = {2768-2775},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.10.6622},
url = {https://revistadechimie.ro/Articles.asp?ID=6622}
}

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