PCR Technique Assisting the Early Diagnosis of Human Papillomavirus A retrospective clinical study

Mensch, Karoly; Szarka, Krisztina; Mensch, Henrik; Dobai, Adrienn; Magyar, Zoltan; Pacurar, Mariana; Vartolomei, Aurel Claudiu; Manuc, Daniela; Nagy, Csaba Dobo

Karoly Mensch, Krisztina Szarka, Henrik Mensch, Adrienn Dobai, Zoltan Magyar, Mariana Pacurar, Aurel Claudiu Vartolomei, Daniela Manuc, Csaba Dobo Nagy

PCR Technique Assisting the Early Diagnosis of Human Papillomavirus A retrospective clinical study

Abstract:

The number of oral cancers associated with Human Papillomavirus (HPV) infection is increasing worldwide. The purpose of this retrospective clinical trial is to investigate the relationship between genital and oral HPV infection and to observe the possibilities of polymerase chain reaction (PCR) technique and the limitations for oral HPV infection. The results of genital and oral HPV screening of 34 female patients and their partner, and 14 single female patients were processed in a private practice in Budapest between 2012 and 2015. After brush-biopsy sampling, HPV DNA identification and typing were performed using PCR technique. All in all 164 samples were typed. HPV DNA was detected in 76 cases (48.20%). HPV was detected in 55 cases from the genital samples (67%), and in 21 cases from the oral samples (25.6%). Genital HPV infection was statistically significantly higher in women (79.2% vs 22,9%, p[0.001). Gender comparison of genital HPV infection showed a statistically significant difference (79.2% for women, 50% for men, p = 0.006). In case of genital HPV infection, the oral HPV infection of the same person is more frequent. In this study, the above mentioned difference is significant for women and not significant for men. HPV16 is the HPV genotype which was identified in the highest ratio(47.2%). PCR technique is capable of the detection of oral HPV infection, but follow-up studies with higher case number , and questionnaire studies are needed to understand HPV transmission more accurately.

Keywords:
polymerase chain reaction; oral cancer; human papillomavirus

Issue: 2018, Volume 69, Issue 10

Pages: 2781-2787

Publication date: 2018/11/15

https://doi.org/10.37358/RC.18.10.6624

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MENSCH, K., SZARKA, K., MENSCH, H., DOBAI, A., MAGYAR, Z., PACURAR, M., VARTOLOMEI, A.C., MANUC, D., NAGY, C.D., PCR Technique Assisting the Early Diagnosis of Human Papillomavirus A retrospective clinical study, Rev. Chim., 69(10), 2018, 2781-2787.

Vancouver
Mensch K, Szarka K, Mensch H, Dobai A, Magyar Z, Pacurar M, Vartolomei AC, Manuc D, Nagy CD. PCR Technique Assisting the Early Diagnosis of Human Papillomavirus A retrospective clinical study. Rev. Chim.[internet]. 2018 Oct;69(10):2781-2787. Available from: https://doi.org/10.37358/RC.18.10.6624

APA 6th edition
Mensch, K., Szarka, K., Mensch, H., Dobai, A., Magyar, Z., Pacurar, M.,... Nagy, C.D. (2018). PCR Technique Assisting the Early Diagnosis of Human Papillomavirus A retrospective clinical study. Revista de Chimie, 69(10), 2781-2787. https://doi.org/10.37358/RC.18.10.6624

Harvard
Mensch, K., Szarka, K., Mensch, H., Dobai, A., Magyar, Z., Pacurar, M., Vartolomei, A.C., Manuc, D., Nagy, C.D. (2018). 'PCR Technique Assisting the Early Diagnosis of Human Papillomavirus A retrospective clinical study', Revista de Chimie, 69(10), pp. 2781-2787. https://doi.org/10.37358/RC.18.10.6624

IEEE
K. Mensch, K. Szarka, H. Mensch, A. Dobai, Z. Magyar, M. Pacurar, A.C. Vartolomei, D. Manuc, C.D. Nagy, "PCR Technique Assisting the Early Diagnosis of Human Papillomavirus A retrospective clinical study". Revista de Chimie, vol. 69, no. 10, pp. 2781-2787, 2018. [online]. https://doi.org/10.37358/RC.18.10.6624

Text
Karoly Mensch, Krisztina Szarka, Henrik Mensch, Adrienn Dobai, Zoltan Magyar, Mariana Pacurar, Aurel Claudiu Vartolomei, Daniela Manuc, Csaba Dobo Nagy,
PCR Technique Assisting the Early Diagnosis of Human Papillomavirus A retrospective clinical study,
Revista de Chimie,
Volume 69, Issue 10,
2018,
Pages 2781-2787,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.10.6624.
(https://revistadechimie.ro/Articles.asp?ID=6624)
Keywords: polymerase chain reaction; oral cancer; human papillomavirus

RIS
TY - JOUR
T1 - PCR Technique Assisting the Early Diagnosis of Human Papillomavirus A retrospective clinical study
A1 - Mensch, Karoly
A2 - Szarka, Krisztina
A3 - Mensch, Henrik
A4 - Dobai, Adrienn
A5 - Magyar, Zoltan
A6 - Pacurar, Mariana
A7 - Vartolomei, Aurel Claudiu
A8 - Manuc, Daniela
A9 - Nagy, Csaba Dobo
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 10
SP - 2781
EP - 2787
UR - https://doi.org/10.37358/RC.18.10.6624
KW - polymerase chain reaction
KW - oral cancer
KW - human papillomavirus
ER -

BibTex
@article{RevCh2018P2781,
author = {Mensch Karoly and Szarka Krisztina and Mensch Henrik and Dobai Adrienn and Magyar Zoltan and Pacurar Mariana and Vartolomei Aurel Claudiu and Manuc Daniela and Nagy Csaba Dobo},
title = {PCR Technique Assisting the Early Diagnosis of Human Papillomavirus A retrospective clinical study},
journal = {Revista de Chimie},
volume = {69},
number = {10},
pages = {2781-2787},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.10.6624},
url = {https://revistadechimie.ro/Articles.asp?ID=6624}
}

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