BOGDAN IOAN COCULESCU, GABI VALERIU DINCA, GHEORGHE MANOLE, VICTOR LORIN PURCAREA, ANA MARIA OPROIU, CRISTINA MARIANA STOCHECI SERUM CONCENTRATION OF HSCRP - POSSIBLE MARKER FOR THERAPY EVALUATION IN LEFT VENTRICULAR DYSFUNCTION WITH PRESERVED EJECTION FRACTION The study on a subset of 208 patients with diastolic dysfunction with the ejection fraction preserved discusses the possibility of circulating CRP levels to be accepted as a diagnostic marker. In order to carry out a comparative analysis of the significance of hsCRP serum values, the study also included a subgroup labeled as control, consisting of the same number of patients, but diagnosed only with painful chronic ischemic cardiopathy - a stable form of angina pectoris. The conclusion of the study is that the circulating level of hs-CRP can be accepted as a diagnostic marker for both ischemic cardiopathy and diastolic dysfunction with preserved ejection fraction. The result, corroborated with data from other studies that recognize the serum concentration of hs-CRP as a predictor marker in cardiovascular disease, supports its usefulness as a marker for cardiac insufficiency with a history of ischemic cardiopathy, without being a marker for assessing the degree of myocardial contractility deficiency.
Keywords: biomarker, hs-CRP (high-sensitive CRP), cardiac insufficiency with preserved ejection fraction (CI with preserved EF), chronic ischemic heart disease