In silico Evaluation of the Antiproliferative Mithocondrial Targeted Mechanism of Action of Some Pentacyclic Triterpene Derivatives

Macasoi, Ioana; Mioc, Marius; Vaduva, Delia Berceanu; Ghiulai, Roxana; Mioc, Alexandra; Soica, Codruta; Muntean, Danina; Dumitrascu, Victor

Ioana Macasoi, Marius Mioc, Delia Berceanu Vaduva, Roxana Ghiulai, Alexandra Mioc, Codruta Soica, Danina Muntean, Victor Dumitrascu

In silico Evaluation of the Antiproliferative Mithocondrial Targeted Mechanism of Action of Some Pentacyclic Triterpene Derivatives

Abstract:

Mitochondria play an important role in regulating cell viability. Mitochondrial dysfunction has been associated with many known pathologies including cancer. Mitocans are a class of compounds that alter important mitochondrial functions in cancer cells thus inducing cellular death. New pentacyclic triterpene derivatives are constantly developed with the aim of obtaining highly active antiproliferative agents. In this study a set of previously synthesized rhodamine B triterpene conjugates, designed as mitocans, were in silico evaluated with the purpose of elucidating their targeted mithocondrial mechanism of action. Molecular docking revealed that the compounds would predominantly interact with proteins that are part of the mithocondrial electron transport chain (ETC), such as NAD(P)H-quinone oxidoreductase (NDH) and succinate dehydrogenase (SDH).

Keywords:
mitochondrial targeting; Rhodamine B; pentacyclic triterpene; molecular docking

Issue: 2018, Volume 69, Issue 12

Pages: 3361-3363

Publication date: 2019/1/15

https://doi.org/10.37358/RC.18.12.6749

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MACASOI, I., MIOC, M., VADUVA, D.B., GHIULAI, R., MIOC, A., SOICA, C., MUNTEAN, D., DUMITRASCU, V., In silico Evaluation of the Antiproliferative Mithocondrial Targeted Mechanism of Action of Some Pentacyclic Triterpene Derivatives, Rev. Chim., 69(12), 2018, 3361-3363.

Vancouver
Macasoi I, Mioc M, Vaduva DB, Ghiulai R, Mioc A, Soica C, Muntean D, Dumitrascu V. In silico Evaluation of the Antiproliferative Mithocondrial Targeted Mechanism of Action of Some Pentacyclic Triterpene Derivatives. Rev. Chim.[internet]. 2018 Dec;69(12):3361-3363. Available from: https://doi.org/10.37358/RC.18.12.6749

APA 6th edition
Macasoi, I., Mioc, M., Vaduva, D.B., Ghiulai, R., Mioc, A., Soica, C., Muntean, D. & Dumitrascu, V. (2018). In silico Evaluation of the Antiproliferative Mithocondrial Targeted Mechanism of Action of Some Pentacyclic Triterpene Derivatives. Revista de Chimie, 69(12), 3361-3363. https://doi.org/10.37358/RC.18.12.6749

Harvard
Macasoi, I., Mioc, M., Vaduva, D.B., Ghiulai, R., Mioc, A., Soica, C., Muntean, D., Dumitrascu, V. (2018). 'In silico Evaluation of the Antiproliferative Mithocondrial Targeted Mechanism of Action of Some Pentacyclic Triterpene Derivatives', Revista de Chimie, 69(12), pp. 3361-3363. https://doi.org/10.37358/RC.18.12.6749

IEEE
I. Macasoi, M. Mioc, D.B. Vaduva, R. Ghiulai, A. Mioc, C. Soica, D. Muntean, V. Dumitrascu, "In silico Evaluation of the Antiproliferative Mithocondrial Targeted Mechanism of Action of Some Pentacyclic Triterpene Derivatives". Revista de Chimie, vol. 69, no. 12, pp. 3361-3363, 2018. [online]. https://doi.org/10.37358/RC.18.12.6749

Text
Ioana Macasoi, Marius Mioc, Delia Berceanu Vaduva, Roxana Ghiulai, Alexandra Mioc, Codruta Soica, Danina Muntean, Victor Dumitrascu,
In silico Evaluation of the Antiproliferative Mithocondrial Targeted Mechanism of Action of Some Pentacyclic Triterpene Derivatives,
Revista de Chimie,
Volume 69, Issue 12,
2018,
Pages 3361-3363,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.12.6749.
(https://revistadechimie.ro/Articles.asp?ID=6749)
Keywords: mitochondrial targeting; Rhodamine B; pentacyclic triterpene; molecular docking

RIS
TY - JOUR
T1 - In silico Evaluation of the Antiproliferative Mithocondrial Targeted Mechanism of Action of Some Pentacyclic Triterpene Derivatives
A1 - Macasoi, Ioana
A2 - Mioc, Marius
A3 - Vaduva, Delia Berceanu
A4 - Ghiulai, Roxana
A5 - Mioc, Alexandra
A6 - Soica, Codruta
A7 - Muntean, Danina
A8 - Dumitrascu, Victor
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 12
SP - 3361
EP - 3363
UR - https://doi.org/10.37358/RC.18.12.6749
KW - mitochondrial targeting
KW - Rhodamine B
KW - pentacyclic triterpene
KW - molecular docking
ER -

BibTex
@article{RevCh2018P3361,
author = {Macasoi Ioana and Mioc Marius and Vaduva Delia Berceanu and Ghiulai Roxana and Mioc Alexandra and Soica Codruta and Muntean Danina and Dumitrascu Victor},
title = {In silico Evaluation of the Antiproliferative Mithocondrial Targeted Mechanism of Action of Some Pentacyclic Triterpene Derivatives},
journal = {Revista de Chimie},
volume = {69},
number = {12},
pages = {3361-3363},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.12.6749},
url = {https://revistadechimie.ro/Articles.asp?ID=6749}
}

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