Peripheral Neurotoxicity Induced by Taxanes, Cisplatin, Oxaliplatin, Fluoropyrimidines and Vinorelbine. A clinical perspective

Nitipir, Cornelia; Baetu, Alexandru; Voinea, Andreea; Pietrosanu, Catalina; Iaciu, Cristian; Voichitescu, Madalina; Hainarosie, Razvan; Orlov, Cristina; Negoita, Silvius Ioan; Dutu, Madalina Alina; Panea, Cristina; Balalau, Cristian

Cornelia Nitipir, Alexandru Baetu, Andreea Voinea, Catalina Pietrosanu, Cristian Iaciu, Madalina Voichitescu, Razvan Hainarosie, Cristina Orlov, Silvius Ioan Negoita, Madalina Alina Dutu, Cristina Panea, Cristian Balalau

Peripheral Neurotoxicity Induced by Taxanes, Cisplatin, Oxaliplatin, Fluoropyrimidines and Vinorelbine. A clinical perspective

Abstract:

Chemotherapy-induced peripheral neuropathy (CIPN) is the type of toxicity that affects treatment decisions often. Oncology specialists usually grade it using Common Terminology Criteria for Adverse Effects version (CTCAE), with some limitations. Dyck scale is a more objective method that is usually used for diabetic neuropathy grading.The present study included retrospectively registered patients (n=80) treated with platinum salts, taxanes, fluoropyrimidines or vinorelbine that subsequently developed CIPN. In some, the decision to lower the chemotherapy dose or withhold the treatment altogether was taken. CIPN was graded using both CTCAE 4.0 and Dyck scale for each patient. The aim of the study was to determine how the grades of each scale influenced the decision on the oncological treatment and whether objective, measurable changes are directly proportional to the impact CIPN has on the patients life. The present study reports high sensibility for both CTCAE and Dyck scale in deciding to modify the dose or interrupt chemotherapy. CTCAE should have more importance for the clinician in the early stages of CIPN. If CIPN presents as advanced, a less subjective alternative like the Dyck scale is a more suitable alternative. Dyck scale should be the most important argument in the decision regarding oncological treatment if the patients’ scores more than 2a on this grading system.The decision to lower the dosage or stop oncological treatment due to CIPN is a complex one and both grading systems are useful. However, when dealing with a more severe case of CIPN, the more objective Dyck scale should be the more important argument.

Keywords:
neurotoxicity; chemotherapy; grading

Issue: 2018, Volume 69, Issue 12

Pages: 3427-3432

Publication date: 2019/1/15

https://doi.org/10.37358/RC.18.12.6763

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
NITIPIR, C., BAETU, A., VOINEA, A., PIETROSANU, C., IACIU, C., VOICHITESCU, M., HAINAROSIE, R., ORLOV, C., NEGOITA, S.I., DUTU, M.A., PANEA, C., BALALAU, C., Peripheral Neurotoxicity Induced by Taxanes, Cisplatin, Oxaliplatin, Fluoropyrimidines and Vinorelbine. A clinical perspective, Rev. Chim., 69(12), 2018, 3427-3432.

Vancouver
Nitipir C, Baetu A, Voinea A, Pietrosanu C, Iaciu C, Voichitescu M, Hainarosie R, Orlov C, Negoita SI, Dutu MA, Panea C, Balalau C. Peripheral Neurotoxicity Induced by Taxanes, Cisplatin, Oxaliplatin, Fluoropyrimidines and Vinorelbine. A clinical perspective. Rev. Chim.[internet]. 2018 Dec;69(12):3427-3432. Available from: https://doi.org/10.37358/RC.18.12.6763

APA 6th edition
Nitipir, C., Baetu, A., Voinea, A., Pietrosanu, C., Iaciu, C., Voichitescu, M.,... Balalau, C. (2018). Peripheral Neurotoxicity Induced by Taxanes, Cisplatin, Oxaliplatin, Fluoropyrimidines and Vinorelbine. A clinical perspective. Revista de Chimie, 69(12), 3427-3432. https://doi.org/10.37358/RC.18.12.6763

Harvard
Nitipir, C., Baetu, A., Voinea, A., Pietrosanu, C., Iaciu, C., Voichitescu, M., Hainarosie, R., Orlov, C., Negoita, S.I., Dutu, M.A., Panea, C., Balalau, C. (2018). 'Peripheral Neurotoxicity Induced by Taxanes, Cisplatin, Oxaliplatin, Fluoropyrimidines and Vinorelbine. A clinical perspective', Revista de Chimie, 69(12), pp. 3427-3432. https://doi.org/10.37358/RC.18.12.6763

IEEE
C. Nitipir, A. Baetu, A. Voinea, C. Pietrosanu, C. Iaciu, M. Voichitescu, R. Hainarosie, C. Orlov, S.I. Negoita, M.A. Dutu, C. Panea, C. Balalau, "Peripheral Neurotoxicity Induced by Taxanes, Cisplatin, Oxaliplatin, Fluoropyrimidines and Vinorelbine. A clinical perspective". Revista de Chimie, vol. 69, no. 12, pp. 3427-3432, 2018. [online]. https://doi.org/10.37358/RC.18.12.6763

Text
Cornelia Nitipir, Alexandru Baetu, Andreea Voinea, Catalina Pietrosanu, Cristian Iaciu, Madalina Voichitescu, Razvan Hainarosie, Cristina Orlov, Silvius Ioan Negoita, Madalina Alina Dutu, Cristina Panea, Cristian Balalau,
Peripheral Neurotoxicity Induced by Taxanes, Cisplatin, Oxaliplatin, Fluoropyrimidines and Vinorelbine. A clinical perspective,
Revista de Chimie,
Volume 69, Issue 12,
2018,
Pages 3427-3432,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.12.6763.
(https://revistadechimie.ro/Articles.asp?ID=6763)
Keywords: neurotoxicity; chemotherapy; grading

RIS
TY - JOUR
T1 - Peripheral Neurotoxicity Induced by Taxanes, Cisplatin, Oxaliplatin, Fluoropyrimidines and Vinorelbine. A clinical perspective
A1 - Nitipir, Cornelia
A2 - Baetu, Alexandru
A3 - Voinea, Andreea
A4 - Pietrosanu, Catalina
A5 - Iaciu, Cristian
A6 - Voichitescu, Madalina
A7 - Hainarosie, Razvan
A8 - Orlov, Cristina
A9 - Negoita, Silvius Ioan
A10 - Dutu, Madalina Alina
A11 - Panea, Cristina
A12 - Balalau, Cristian
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 12
SP - 3427
EP - 3432
UR - https://doi.org/10.37358/RC.18.12.6763
KW - neurotoxicity
KW - chemotherapy
KW - grading
ER -

BibTex
@article{RevCh2018P3427,
author = {Nitipir Cornelia and Baetu Alexandru and Voinea Andreea and Pietrosanu Catalina and Iaciu Cristian and Voichitescu Madalina and Hainarosie Razvan and Orlov Cristina and Negoita Silvius Ioan and Dutu Madalina Alina and Panea Cristina and Balalau Cristian},
title = {Peripheral Neurotoxicity Induced by Taxanes, Cisplatin, Oxaliplatin, Fluoropyrimidines and Vinorelbine. A clinical perspective},
journal = {Revista de Chimie},
volume = {69},
number = {12},
pages = {3427-3432},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.12.6763},
url = {https://revistadechimie.ro/Articles.asp?ID=6763}
}

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