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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 12, 3500-3502

https://doi.org/10.37358/RC.18.12.6778

Ana Maria Trofin, Mihai Zabara, Ramona Cadar, Madalina Palaghia, Delia Rusu-Andriesi, Bogdan Mihnea Ciuntu, Irene Alexandra Spiridon, Cristian Lupascu

The Influence of Diabetes Mellitus in Development and Prognostic of Pancreatic Neoplasia

Abstract:

Pancreatic cancer is one of the most aggressive malignant diseases due high rate of recurrence and the lack effective medical therapy. Surgery remains the only option for curable treatment but unfortunately, less than 20% of patients are eligibles at the time of diagnosis therefore identifying the risk factors represent a big step for cancer research. Pancreatic cancer is frequently associated with diabetes or glucose intolerance. There are two hypotheses at the base of this observation: either the diabetes cause pancreatic cancer or is a concequences of the cancer. In these theses we studied the patients diagnosticated with pancreatic cancer and with diabetes mellitus type 2. A total of 256 pancreatic cancer cases were identified and 71 patients had diabetes mellitus and 21 patients had glucose intolerance. Mean age 62.2 years, 81% cases were male and in 71% cancer originated form the pancreatic head. In 51.4% cases the diagnosis was in stage IV of the disease. Patients with pancreatic cancer and diabetes mellitus had reduced survival compared with those without diabetes but the difference was not statistically significant. Diabetes mellitus is associated with a decreased survival among patients with pancreatic cancer and reveal a link between chronic glucose intolerance and pancreatic cancer survival. The complex relationship between pancreatic cancer and diabetes requires more clinical research in order to developed new therapeutical posibilities.
Keywords:
pancreatic cancer; diabetes mielitus; survival; glucose intolerance

Issue: 2018, Volume 69, Issue 12
Pages: 3500-3502
Publication date: 2019/1/15
https://doi.org/10.37358/RC.18.12.6778
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
TROFIN, A.M., ZABARA, M., CADAR, R., PALAGHIA, M., RUSU-ANDRIESI, D., CIUNTU, B.M., SPIRIDON, I.A., LUPASCU, C., The Influence of Diabetes Mellitus in Development and Prognostic of Pancreatic Neoplasia, Rev. Chim., 69(12), 2018, 3500-3502.

Vancouver
Trofin AM, Zabara M, Cadar R, Palaghia M, Rusu-Andriesi D, Ciuntu BM, Spiridon IA, Lupascu C. The Influence of Diabetes Mellitus in Development and Prognostic of Pancreatic Neoplasia. Rev. Chim.[internet]. 2018 Dec;69(12):3500-3502. Available from: https://doi.org/10.37358/RC.18.12.6778


APA 6th edition
Trofin, A.M., Zabara, M., Cadar, R., Palaghia, M., Rusu-Andriesi, D., Ciuntu, B.M., Spiridon, I.A. & Lupascu, C. (2018). The Influence of Diabetes Mellitus in Development and Prognostic of Pancreatic Neoplasia. Revista de Chimie, 69(12), 3500-3502. https://doi.org/10.37358/RC.18.12.6778


Harvard
Trofin, A.M., Zabara, M., Cadar, R., Palaghia, M., Rusu-Andriesi, D., Ciuntu, B.M., Spiridon, I.A., Lupascu, C. (2018). 'The Influence of Diabetes Mellitus in Development and Prognostic of Pancreatic Neoplasia', Revista de Chimie, 69(12), pp. 3500-3502. https://doi.org/10.37358/RC.18.12.6778


IEEE
A.M. Trofin, M. Zabara, R. Cadar, M. Palaghia, D. Rusu-Andriesi, B.M. Ciuntu, I.A. Spiridon, C. Lupascu, "The Influence of Diabetes Mellitus in Development and Prognostic of Pancreatic Neoplasia". Revista de Chimie, vol. 69, no. 12, pp. 3500-3502, 2018. [online]. https://doi.org/10.37358/RC.18.12.6778


Text
Ana Maria Trofin, Mihai Zabara, Ramona Cadar, Madalina Palaghia, Delia Rusu-Andriesi, Bogdan Mihnea Ciuntu, Irene Alexandra Spiridon, Cristian Lupascu,
The Influence of Diabetes Mellitus in Development and Prognostic of Pancreatic Neoplasia,
Revista de Chimie,
Volume 69, Issue 12,
2018,
Pages 3500-3502,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.12.6778.
(https://revistadechimie.ro/Articles.asp?ID=6778)
Keywords: pancreatic cancer; diabetes mielitus; survival; glucose intolerance


RIS
TY - JOUR
T1 - The Influence of Diabetes Mellitus in Development and Prognostic of Pancreatic Neoplasia
A1 - Trofin, Ana Maria
A2 - Zabara, Mihai
A3 - Cadar, Ramona
A4 - Palaghia, Madalina
A5 - Rusu-Andriesi, Delia
A6 - Ciuntu, Bogdan Mihnea
A7 - Spiridon, Irene Alexandra
A8 - Lupascu, Cristian
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 12
SP - 3500
EP - 3502
UR - https://doi.org/10.37358/RC.18.12.6778
KW - pancreatic cancer
KW - diabetes mielitus
KW - survival
KW - glucose intolerance
ER -


BibTex
@article{RevCh2018P3500,
author = {Trofin Ana Maria and Zabara Mihai and Cadar Ramona and Palaghia Madalina and Rusu-Andriesi Delia and Ciuntu Bogdan Mihnea and Spiridon Irene Alexandra and Lupascu Cristian},
title = {The Influence of Diabetes Mellitus in Development and Prognostic of Pancreatic Neoplasia},
journal = {Revista de Chimie},
volume = {69},
number = {12},
pages = {3500-3502},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.12.6778},
url = {https://revistadechimie.ro/Articles.asp?ID=6778}
}
 
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