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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 12, 3520-3523

https://doi.org/10.37358/RC.18.12.6783

Raluca Alexandra Trifanescu, Dan Soare, Catalin Carstoiu, Gheorghe Popescu, Alina Mihaela Pascu, Vladimir Poroch, Sebastian Toma, Catalina Poiana

Mild Chronic Hyponatremia and Osteoporotic Fractures Risk in Elderly

Abstract:

Low serum sodium levels were associated with increased prevalence of osteoporosis and fractures. The aim of the study was to assess the relationship between serum sodium and bone mineral density and/or osteoporotic fractures’ prevalence in elderly people. A total number of 260 patients (23 men / 237 women), aged 66.5 ± 12.8 years, were retrospectively assessed. Serum sodium levels were measured in all patients. Bone mineral density (BMD) was measured by dual X-ray absorptiometry (DXA). Results: serum natremia was 140.3 ± 4.4 mmol/L; prevalence of hyponatremia was 7.3%; frailty fractures were present in 117 out of 260 patients (45%). Patients with fractures had lower serum sodium levels as compared to patients without fractures (139 ± 3.9 vs. 141.5 ± 4.6 mmol/L, p [ 0.001). Patients with osteoporosis (n = 179) also showed lower natremia as compared to patients with normal BMD and osteopenia (n = 81): 139.9 ± 4.7 vs. 141.2 ± 3.8 mmol/L, p = 0.035. In patients admitted in the hospital for fractures (n = 92), prevalence of hyponatremia was 13.04%. Hyponatremic patients had significantly higher prevalence of fractures (73.7% vs. 42.7%, p = 0.0147) as compared to normonatremic patients. Odds ratio (OR) for fractures in patients with hyponatremia was 3.75 [95% C.I.: 1.3-10.75], p = 0.0138; OR for hip fractures in patients with hyponatremia was 3.65 [95% C.I.: 1.38-9.64], p = 0.0089. Both incidence and prevalence of hyponatremia increase with age, especially in patients treated with diuretics. Several clinical studies found an association between mild chronic hyponatremia in elderly and increased odds ratio of osteoporosis at the total and at femoral neck; the study also showed an increased odds ratio for all fractures and for hip fractures in hyponatremic patients. Elderly people at risk of osteoporotic fractures should have sodium serum measured.
Keywords:
hyponatremia; osteoporosis; fall-related fractures; bone remodelling; frailty

Issue: 2018, Volume 69, Issue 12
Pages: 3520-3523
Publication date: 2019/1/15
https://doi.org/10.37358/RC.18.12.6783
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
TRIFANESCU, R.A., SOARE, D., CARSTOIU, C., POPESCU, G., PASCU, A.M., POROCH, V., TOMA, S., POIANA, C., Mild Chronic Hyponatremia and Osteoporotic Fractures Risk in Elderly, Rev. Chim., 69(12), 2018, 3520-3523.

Vancouver
Trifanescu RA, Soare D, Carstoiu C, Popescu G, Pascu AM, Poroch V, Toma S, Poiana C. Mild Chronic Hyponatremia and Osteoporotic Fractures Risk in Elderly. Rev. Chim.[internet]. 2018 Dec;69(12):3520-3523. Available from: https://doi.org/10.37358/RC.18.12.6783


APA 6th edition
Trifanescu, R.A., Soare, D., Carstoiu, C., Popescu, G., Pascu, A.M., Poroch, V., Toma, S. & Poiana, C. (2018). Mild Chronic Hyponatremia and Osteoporotic Fractures Risk in Elderly. Revista de Chimie, 69(12), 3520-3523. https://doi.org/10.37358/RC.18.12.6783


Harvard
Trifanescu, R.A., Soare, D., Carstoiu, C., Popescu, G., Pascu, A.M., Poroch, V., Toma, S., Poiana, C. (2018). 'Mild Chronic Hyponatremia and Osteoporotic Fractures Risk in Elderly', Revista de Chimie, 69(12), pp. 3520-3523. https://doi.org/10.37358/RC.18.12.6783


IEEE
R.A. Trifanescu, D. Soare, C. Carstoiu, G. Popescu, A.M. Pascu, V. Poroch, S. Toma, C. Poiana, "Mild Chronic Hyponatremia and Osteoporotic Fractures Risk in Elderly". Revista de Chimie, vol. 69, no. 12, pp. 3520-3523, 2018. [online]. https://doi.org/10.37358/RC.18.12.6783


Text
Raluca Alexandra Trifanescu, Dan Soare, Catalin Carstoiu, Gheorghe Popescu, Alina Mihaela Pascu, Vladimir Poroch, Sebastian Toma, Catalina Poiana,
Mild Chronic Hyponatremia and Osteoporotic Fractures Risk in Elderly,
Revista de Chimie,
Volume 69, Issue 12,
2018,
Pages 3520-3523,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.12.6783.
(https://revistadechimie.ro/Articles.asp?ID=6783)
Keywords: hyponatremia; osteoporosis; fall-related fractures; bone remodelling; frailty


RIS
TY - JOUR
T1 - Mild Chronic Hyponatremia and Osteoporotic Fractures Risk in Elderly
A1 - Trifanescu, Raluca Alexandra
A2 - Soare, Dan
A3 - Carstoiu, Catalin
A4 - Popescu, Gheorghe
A5 - Pascu, Alina Mihaela
A6 - Poroch, Vladimir
A7 - Toma, Sebastian
A8 - Poiana, Catalina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 12
SP - 3520
EP - 3523
UR - https://doi.org/10.37358/RC.18.12.6783
KW - hyponatremia
KW - osteoporosis
KW - fall-related fractures
KW - bone remodelling
KW - frailty
ER -


BibTex
@article{RevCh2018P3520,
author = {Trifanescu Raluca Alexandra and Soare Dan and Carstoiu Catalin and Popescu Gheorghe and Pascu Alina Mihaela and Poroch Vladimir and Toma Sebastian and Poiana Catalina},
title = {Mild Chronic Hyponatremia and Osteoporotic Fractures Risk in Elderly},
journal = {Revista de Chimie},
volume = {69},
number = {12},
pages = {3520-3523},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.12.6783},
url = {https://revistadechimie.ro/Articles.asp?ID=6783}
}
 
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