GEORGE BRATULESCU 2-SUBSTITUTED BENZIMIDAZOLE SYNTHESIS IN DRY MEDIUM MEDIATED BY PYRIDINE N-OXIDE
Substituted benzimidazoles were obtained from o-phenylenediamine and organic halides in solvent-free medium. The procedure involves pyridine N-oxide as mild oxidizing agent. The benzimidazoles were prepared without the separation of the intermediates. The absence of catalysts and good yields are important benefits of the method.