CORINA EUGENIA BUDIN, CORINA MARGINEAN, IOANA ROXANA BORDEA, LIVIU SILVIU ENACHE, ELENA LUMINITA ENACHE, BIANCA LIANA GRIGORESCU, LEVENTE BIRO, ELENA RUSU, ROXANA MARIA NEMES, DOINA ADINA TODEA THE INFLUENCE OF SMOKING ON NICOTINE EXPOSURE BIOMARKERS AND INFLAMMATORY PROFILE AMONG FOSTER CARE TEENAGERS, ROMANIA Foster care young people have an increased overall risk for the development of chronic health conditions.Smoking is a major risk factor for many conditions with inflammatory component. We performed a cross-sectional pilot study to assess the correlation between tobacco consumption status and inflammatory profile among adolescents living with foster parents in the central region of Romania. A number of 35 teenagers aged 10-18 were enrolled. Blood samples were collected by venipuncture for complete blood count (CBC), fibrinogen, Interleukin-6 (IL 6), C reactive protein (CRP). Exhaled CO was measured and urine samples were collected in the same session for cotinine assessment. Of the 123 teenagers initially enrolled, 35 completed the entire study protocol. Urinary cotinine accurately reflected smoker status. Smoking did not affect hemoglobin levels or other hematological parameters in foster care teenagers. The value of C-reactive protein was higher in smokers. Plasma fibrinogen correlated with the daily number of cigarettes. Interleukin-6 did not correlate with the smoker status or the daily number of cigarettes consumed. Our study highlights the existence of an inflammatory response to smoking in foster care adolescents, a social category otherwise predisposed to various addictive behaviors.
Keywords: foster care teenagers, smoking, inflammatory profile, biomarkers, prevention