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REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 12, 3675-3679

https://doi.org/10.37358/RC.18.12.6817

Laura Endres, Delia Mirela Tit, Simona Bungau, Gabriela Cioca, Mohamed Abdel Daim, Camelia Buhas, Ovidiu Pop, Cristian Sava

Markers Usefulness in the Melanic Metastatic Cellular Epitops Identification in the Sentinel Lymph Node

Abstract:

Cutaneous melanoma is the most severe skin neoplasia with an increased incidence in the recent decades, particularly due to the intense exposure to sunlight. Our study analyzed the characteristics of malignant melanoma and the role of sentinel node biopsy in the diagnosis and prognosis of the patients with cutaneous melanoma by identifying the regional metastasis. The small or large clusters of circulating cancer cells are expressing epitops identified by some chemical reaction. These reagents are usually monoclonal antibodies with high sensitivity and specificity which are matching with the right receptor from the melanoma cells. The result is an antibody-antigen complex high-light in the microscopic examination by 3,3'-diaminobenzidine (DAB). The study was conducted on a sample of 151 patients diagnosed with melanoma in different developmental stages: 62 had Breslow index between 1-4 mm, 71 patients had Breslow index Ă 4 mm and 18 patients had Breslow index [ 1 mm. 45 patients (out of 62) with Breslow index between 1-4 mm had SLN positive. The mortality rate was 5% in the case of the patients with SLN positive. Comparing the rate of mortality by considering the Breslow index, 65% of the patients with Breslow index Ă 4 mm died. The correct identification of the patients with negative sentinel node or positive sentinel node improves staging and can facilitate the subsequent therapeutic decision, which is useful for early identification of the micro metastases and of the patients who require regional complete lymph node dissection.
Keywords:
malignant melanoma; sentinel node; prognostic

Issue: 2018, Volume 69, Issue 12
Pages: 3675-3679
Publication date: 2019/1/15
https://doi.org/10.37358/RC.18.12.6817
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
ENDRES, L., TIT, D.M., BUNGAU, S., CIOCA, G., DAIM, M.A., BUHAS, C., POP, O., SAVA, C., Markers Usefulness in the Melanic Metastatic Cellular Epitops Identification in the Sentinel Lymph Node, Rev. Chim., 69(12), 2018, 3675-3679.

Vancouver
Endres L, Tit DM, Bungau S, Cioca G, Daim MA, Buhas C, Pop O, Sava C. Markers Usefulness in the Melanic Metastatic Cellular Epitops Identification in the Sentinel Lymph Node. Rev. Chim.[internet]. 2018 Dec;69(12):3675-3679. Available from: https://doi.org/10.37358/RC.18.12.6817


APA 6th edition
Endres, L., Tit, D.M., Bungau, S., Cioca, G., Daim, M.A., Buhas, C., Pop, O. & Sava, C. (2018). Markers Usefulness in the Melanic Metastatic Cellular Epitops Identification in the Sentinel Lymph Node. Revista de Chimie, 69(12), 3675-3679. https://doi.org/10.37358/RC.18.12.6817


Harvard
Endres, L., Tit, D.M., Bungau, S., Cioca, G., Daim, M.A., Buhas, C., Pop, O., Sava, C. (2018). 'Markers Usefulness in the Melanic Metastatic Cellular Epitops Identification in the Sentinel Lymph Node', Revista de Chimie, 69(12), pp. 3675-3679. https://doi.org/10.37358/RC.18.12.6817


IEEE
L. Endres, D.M. Tit, S. Bungau, G. Cioca, M.A. Daim, C. Buhas, O. Pop, C. Sava, "Markers Usefulness in the Melanic Metastatic Cellular Epitops Identification in the Sentinel Lymph Node". Revista de Chimie, vol. 69, no. 12, pp. 3675-3679, 2018. [online]. https://doi.org/10.37358/RC.18.12.6817


Text
Laura Endres, Delia Mirela Tit, Simona Bungau, Gabriela Cioca, Mohamed Abdel Daim, Camelia Buhas, Ovidiu Pop, Cristian Sava,
Markers Usefulness in the Melanic Metastatic Cellular Epitops Identification in the Sentinel Lymph Node,
Revista de Chimie,
Volume 69, Issue 12,
2018,
Pages 3675-3679,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.12.6817.
(https://revistadechimie.ro/Articles.asp?ID=6817)
Keywords: malignant melanoma; sentinel node; prognostic


RIS
TY - JOUR
T1 - Markers Usefulness in the Melanic Metastatic Cellular Epitops Identification in the Sentinel Lymph Node
A1 - Endres, Laura
A2 - Tit, Delia Mirela
A3 - Bungau, Simona
A4 - Cioca, Gabriela
A5 - Daim, Mohamed Abdel
A6 - Buhas, Camelia
A7 - Pop, Ovidiu
A8 - Sava, Cristian
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 12
SP - 3675
EP - 3679
UR - https://doi.org/10.37358/RC.18.12.6817
KW - malignant melanoma
KW - sentinel node
KW - prognostic
ER -


BibTex
@article{RevCh2018P3675,
author = {Endres Laura and Tit Delia Mirela and Bungau Simona and Cioca Gabriela and Daim Mohamed Abdel and Buhas Camelia and Pop Ovidiu and Sava Cristian},
title = {Markers Usefulness in the Melanic Metastatic Cellular Epitops Identification in the Sentinel Lymph Node},
journal = {Revista de Chimie},
volume = {69},
number = {12},
pages = {3675-3679},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.12.6817},
url = {https://revistadechimie.ro/Articles.asp?ID=6817}
}
 
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