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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 12, 3702-3704

https://doi.org/10.37358/RC.18.12.6823

Oana Viola Badulescu, Manuela Ciocoiu, Nina Filip, Vlad Vering

The Efficiency of Substitutive Treatment with Moroctocog Alfa in Managing Hemostasis in Patients with Hemophilia A Without Inhibitors With Total Knee Arthroplasties

Abstract:

Hemophilia A is a hereditary coagulopathy caused by the deficiency of the coagulation factor VIII, whose main complication consists in disabling arthropathy. The most often affected joint is the one of the knee, due to which this article aims at presenting, on one hand, the role of continuous substitutive prophylactic treatment in preventing the onset of this complication and, on the other hand, the current view of orthopedic surgery in managing the above-mentioned complication. The continuous prophylactic treatment represents the best therapeutic conduct in preventing the onset of hemophilic arthropathy, yet this aspect is limited by two important factors: inappropriate medical support, dependence on the social and economic level of every country and inappropriate adherence of the patient to this thorough treatment, which represents a challenge for a life with no bleeding. Under the circumstances imposed by an insufficient substitutive treatment or by a deficient adherence of the patient to this, recurrent hemarthrosis shall lead to cartilage destruction and synovial hypertrophy (synovitis), which will impose, in time, total endoprosthesis in order to re-establish the motor function and to improve the life quality of the hemophilic patient. The surgery of the hemophilic patient is associated with an increased risk of hemorrhage and infection and it is practiced only with substitutive hematologic support. The key to the best results is the existence of a multidisciplinary experienced team, including an orthopedist, hematologist, physical therapist.
Keywords:
Hemophilia A; arthropathy; hemarthrosis; synovial hypertrophy

Issue: 2018, Volume 69, Issue 12
Pages: 3702-3704
Publication date: 2019/1/15
https://doi.org/10.37358/RC.18.12.6823
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
BADULESCU, O.V., CIOCOIU, M., FILIP, N., VERING, V., The Efficiency of Substitutive Treatment with Moroctocog Alfa in Managing Hemostasis in Patients with Hemophilia A Without Inhibitors With Total Knee Arthroplasties, Rev. Chim., 69(12), 2018, 3702-3704.

Vancouver
Badulescu OV, Ciocoiu M, Filip N, Vering V. The Efficiency of Substitutive Treatment with Moroctocog Alfa in Managing Hemostasis in Patients with Hemophilia A Without Inhibitors With Total Knee Arthroplasties. Rev. Chim.[internet]. 2018 Dec;69(12):3702-3704. Available from: https://doi.org/10.37358/RC.18.12.6823


APA 6th edition
Badulescu, O.V., Ciocoiu, M., Filip, N. & Vering, V. (2018). The Efficiency of Substitutive Treatment with Moroctocog Alfa in Managing Hemostasis in Patients with Hemophilia A Without Inhibitors With Total Knee Arthroplasties. Revista de Chimie, 69(12), 3702-3704. https://doi.org/10.37358/RC.18.12.6823


Harvard
Badulescu, O.V., Ciocoiu, M., Filip, N., Vering, V. (2018). 'The Efficiency of Substitutive Treatment with Moroctocog Alfa in Managing Hemostasis in Patients with Hemophilia A Without Inhibitors With Total Knee Arthroplasties', Revista de Chimie, 69(12), pp. 3702-3704. https://doi.org/10.37358/RC.18.12.6823


IEEE
O.V. Badulescu, M. Ciocoiu, N. Filip, V. Vering, "The Efficiency of Substitutive Treatment with Moroctocog Alfa in Managing Hemostasis in Patients with Hemophilia A Without Inhibitors With Total Knee Arthroplasties". Revista de Chimie, vol. 69, no. 12, pp. 3702-3704, 2018. [online]. https://doi.org/10.37358/RC.18.12.6823


Text
Oana Viola Badulescu, Manuela Ciocoiu, Nina Filip, Vlad Vering,
The Efficiency of Substitutive Treatment with Moroctocog Alfa in Managing Hemostasis in Patients with Hemophilia A Without Inhibitors With Total Knee Arthroplasties,
Revista de Chimie,
Volume 69, Issue 12,
2018,
Pages 3702-3704,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.12.6823.
(https://revistadechimie.ro/Articles.asp?ID=6823)
Keywords: Hemophilia A; arthropathy; hemarthrosis; synovial hypertrophy


RIS
TY - JOUR
T1 - The Efficiency of Substitutive Treatment with Moroctocog Alfa in Managing Hemostasis in Patients with Hemophilia A Without Inhibitors With Total Knee Arthroplasties
A1 - Badulescu, Oana Viola
A2 - Ciocoiu, Manuela
A3 - Filip, Nina
A4 - Vering, Vlad
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 12
SP - 3702
EP - 3704
UR - https://doi.org/10.37358/RC.18.12.6823
KW - Hemophilia A
KW - arthropathy
KW - hemarthrosis
KW - synovial hypertrophy
ER -


BibTex
@article{RevCh2018P3702,
author = {Badulescu Oana Viola and Ciocoiu Manuela and Filip Nina and Vering Vlad},
title = {The Efficiency of Substitutive Treatment with Moroctocog Alfa in Managing Hemostasis in Patients with Hemophilia A Without Inhibitors With Total Knee Arthroplasties},
journal = {Revista de Chimie},
volume = {69},
number = {12},
pages = {3702-3704},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.12.6823},
url = {https://revistadechimie.ro/Articles.asp?ID=6823}
}
 
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