IONUT DRAGOSTIN, OANA MARIA DRAGOSTIN, MARIA DRAGAN, CATALINA DANIELA STAN, CARMEN LACRAMIOARA ZAMFIR DRUG HYPERSENSITIVITY REDUCTION USING ENCAPSULATION METHOD WITH CHITOSAN-CETIRIZINE DERIVATIVES The ideal material for encapsulation should have good rheological properties, good dispersing capacity of active substances, lack of chemical reactivity with encapsulated substances, the ability to complete release the active compounds, under different conditions, solubility in non-toxic solvents. The degree of novelty of this work consists in applying a preclinical solution for reducing the risk of allergic reaction manifestation, after the treatment with therapeutic agents with allergic potential, as it is the case of beta-lactam antibiotics or non-steroidal anti-inflammatory drugs. The originality of this research it is based on obtaining new chitosan derivatives, starting from cetirizine which is well known for its antihistaminic properties, followed by the use of these new derivatives for encapsulation of drugs with allergic potential. The obtained particles will lead to the reducing of the drug hypersensitivity, keeping, at the same time, the followed therapeutic effect.
Keywords: chitosan-cetirizine, encapsulation, drug hypersensitivity, microparticles