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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 12, 3731-3735

https://doi.org/10.37358/RC.18.12.6830

Ionut Dragostin, Oana Maria Dragostin, Maria Dragan, Catalina Daniela Stan, Carmen Lacramioara Zamfir

Drug Hypersensitivity Reduction Using Encapsulation Method with Chitosan-Cetirizine Derivatives

Abstract:

The ideal material for encapsulation should have good rheological properties, good dispersing capacity of active substances, lack of chemical reactivity with encapsulated substances, the ability to complete release the active compounds, under different conditions, solubility in non-toxic solvents. The degree of novelty of this work consists in applying a preclinical solution for reducing the risk of allergic reaction manifestation, after the treatment with therapeutic agents with allergic potential, as it is the case of beta-lactam antibiotics or non-steroidal anti-inflammatory drugs. The originality of this research it is based on obtaining new chitosan derivatives, starting from cetirizine which is well known for its antihistaminic properties, followed by the use of these new derivatives for encapsulation of drugs with allergic potential. The obtained particles will lead to the reducing of the drug hypersensitivity, keeping, at the same time, the followed therapeutic effect.
Keywords:
chitosan-cetirizine; encapsulation; drug hypersensitivity; microparticles

Issue: 2018, Volume 69, Issue 12
Pages: 3731-3735
Publication date: 2019/1/15
https://doi.org/10.37358/RC.18.12.6830
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
DRAGOSTIN, I., DRAGOSTIN, O.M., DRAGAN, M., STAN, C.D., ZAMFIR, C.L., Drug Hypersensitivity Reduction Using Encapsulation Method with Chitosan-Cetirizine Derivatives, Rev. Chim., 69(12), 2018, 3731-3735.

Vancouver
Dragostin I, Dragostin OM, Dragan M, Stan CD, Zamfir CL. Drug Hypersensitivity Reduction Using Encapsulation Method with Chitosan-Cetirizine Derivatives. Rev. Chim.[internet]. 2018 Dec;69(12):3731-3735. Available from: https://doi.org/10.37358/RC.18.12.6830


APA 6th edition
Dragostin, I., Dragostin, O.M., Dragan, M., Stan, C.D. & Zamfir, C.L. (2018). Drug Hypersensitivity Reduction Using Encapsulation Method with Chitosan-Cetirizine Derivatives. Revista de Chimie, 69(12), 3731-3735. https://doi.org/10.37358/RC.18.12.6830


Harvard
Dragostin, I., Dragostin, O.M., Dragan, M., Stan, C.D., Zamfir, C.L. (2018). 'Drug Hypersensitivity Reduction Using Encapsulation Method with Chitosan-Cetirizine Derivatives', Revista de Chimie, 69(12), pp. 3731-3735. https://doi.org/10.37358/RC.18.12.6830


IEEE
I. Dragostin, O.M. Dragostin, M. Dragan, C.D. Stan, C.L. Zamfir, "Drug Hypersensitivity Reduction Using Encapsulation Method with Chitosan-Cetirizine Derivatives". Revista de Chimie, vol. 69, no. 12, pp. 3731-3735, 2018. [online]. https://doi.org/10.37358/RC.18.12.6830


Text
Ionut Dragostin, Oana Maria Dragostin, Maria Dragan, Catalina Daniela Stan, Carmen Lacramioara Zamfir,
Drug Hypersensitivity Reduction Using Encapsulation Method with Chitosan-Cetirizine Derivatives,
Revista de Chimie,
Volume 69, Issue 12,
2018,
Pages 3731-3735,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.12.6830.
(https://revistadechimie.ro/Articles.asp?ID=6830)
Keywords: chitosan-cetirizine; encapsulation; drug hypersensitivity; microparticles


RIS
TY - JOUR
T1 - Drug Hypersensitivity Reduction Using Encapsulation Method with Chitosan-Cetirizine Derivatives
A1 - Dragostin, Ionut
A2 - Dragostin, Oana Maria
A3 - Dragan, Maria
A4 - Stan, Catalina Daniela
A5 - Zamfir, Carmen Lacramioara
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 12
SP - 3731
EP - 3735
UR - https://doi.org/10.37358/RC.18.12.6830
KW - chitosan-cetirizine
KW - encapsulation
KW - drug hypersensitivity
KW - microparticles
ER -


BibTex
@article{RevCh2018P3731,
author = {Dragostin Ionut and Dragostin Oana Maria and Dragan Maria and Stan Catalina Daniela and Zamfir Carmen Lacramioara},
title = {Drug Hypersensitivity Reduction Using Encapsulation Method with Chitosan-Cetirizine Derivatives},
journal = {Revista de Chimie},
volume = {69},
number = {12},
pages = {3731-3735},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.12.6830},
url = {https://revistadechimie.ro/Articles.asp?ID=6830}
}
 
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