VICTOR VLAD COSTAN, ANCA SAVA, ALEXANDRU CARAULEANU, CLAUDIA FLORIDA COSTEA, ANDREI IONUT CUCU, GABRIELA DIMITRIU, GABRIELA FLORENTA DUMITRESCU, NICOLETA DUMITRESCU, MARIA SILVIA STOICESCU, GHEORGHE RAFTU, MIHAELA DANA TURLIUC HISTOPATHOLOGICAL AND CLINICAL CHARACTERISTICS OF SURGICALLY REMOVED CAVERNOUS VENOUS MALFORMATIONS (SO-CALLED CAVERNOUS HEMANGIOMAS) OF THE ORBIT Cavernous venous malformation (CVM) is the most common primary vascular lesion of the orbit. The aim of this study is to present authors ‘experience regarding fourteen patients with orbital CVM (so-called cavernous hemangioma) and identify their clinical and histopathological particular characteristics. From 2010 to 2017 a total of 14 patients were diagnosed with orbital cavernous hemangiomas and treated by the authors. Patients’ socio-demographic, clinical, radiological, and surgical findings were retrospectively retrieved from medical records and analyzed. Diagnosis of a cavernous hemangioma was confirmed histologically in all cases. Results: All 14 patients were females, with a mean age of 44.2 years old, ranging from 13 years to 57 years. The left orbit was affected in eleven (78.57%) cases. A painless, gradually progressive proptosis and visual disturbance were the main clinical signs. In four (28.57%) cases, the lesion was incidentally discovered at imaging evaluations for persistent headache. All patients were accurately diagnosed preoperatively based on computed tomography (CT) exam or magnetic resonance imaging (MRI). The tumors were removed successfully by anterior orbitotomy. Transconjunctival approach proved to be an important surgical procedure in their treatment, with excellent results and a low risk of complications. Histologically, all lesions revealed large vascular channels with endothelium lining and multilaminar smooth muscle layers in their walls, but also nests of small capillary channels in interstitium. No intravascular thrombosis or stromal lymphocytes could be seen. Orbital cavernous hemangiomas presented clinical, imaging and histological features of a benign lesion. Having to deal with extraconal lesions, we successfully used anterior orbitotomy, mainly the transconjuctival approach, with no complications or recurrences after a six-month follow-up period. Histologically, all lesions revealed images being most closely to dysplastic veins. So, we concluded that the so-called orbital cavernous hemangioma was rather a cavernous venous malformation.