DANA VARASTEANU, IRINA CHICAN, SANDA MARIA DONCEA, IULIANA RAUT, MARIANA CALIN, LUIZA JECU NICKEL (II) AND COBALT (II) COMPLEXES OF SOME AMINO ACID-BASED SURFACTANTS WITH ANTIMICROBIAL ACTIVITY Nickel and cobalt complexes of lauroyl-glycine, lauroyl-glycylglycine and 1,12-dodecandioyl-diglycylglycine were synthesized. The FTIR spectroscopy confirmed the complex formation. The antimicrobial activity of synthesized nickel and cobalt complexes was investigated against several bacteria and fungi: Bacillus cereus, Pseudomonas aeruginosa, Candida albicans, and Aspergillus flavus. Generally, the nickel and cobalt complexes of the investigated surfactants showed no antimicrobial activity on Pseudomonas aeruginosa, a moderate one on Bacillus cereus and Aspergillus flavus. The most susceptible microorganism was Candida albicans, which is considered one of most common nosocomial infections. The results suggest the potential application of tested compounds as antimicrobial agents against targeted pathogens.
Keywords: amino acid-based surfactants, metal complex, antimicrobial activity