LEONARD NASTASE, LUIZA RADULESCU, MONICA LUMINITA LUMINOS, MARIA MADALINA MERISESCU, GHEORGHITA JUGULETE, SILVIA MARIA STOICESCU SEVERE MODIFICATIONS OF BIOLOGICAL MARKERS IN LATE NEONATAL SEPSIS IN A VERY LOW BIRTH WEIGHT DUE TO CANDIDA LUSITANIAE Neonatal sepsis is a major cause of neonatal mortality and morbidity in preterm, very low birth weight infants. Coagulase-negative staphylococcus and Candida spp. are among the most common causes of single infections and coinfections in neonates. Candida lusitaniae is rarely reported as an opportunistic pathogen in very low birth weight neonates. Early diagnosis and appropriate antifungal therapy can prevent morbidity and mortality in preterms especially in coinfections. Necrotizing enterocolitis is one of the most catastrophic gastrointestinal emergencies in premature infants in the intensive care neonatal unit, especially in preterm infants. Currently, the pathogenesis of necrotizing enterocolitis is believed to have multifactorial causes. We present the case of a very low birth weight preterm who developed necrotizing enterocolitis and sepsis caused by a coinfection of Coagulase-negative Staphylococcus and Candida lusitaniae.