Nocturnal Hypoxemia, a Key Parameter in Overlap Syndrome

Budin, Corina Eugenia; Maierean, Anca Diana; Ianosi, Edith Simona; Socaci, Adriana; Buzoianu, Anca Dana; Alexescu, Teodora Gabriela; Olteanu, Mihai; Rusu, Elena; Moldovan, Cosmin Alec; Nemes, Roxana Maria

Corina Eugenia Budin, Anca Diana Maierean, Edith Simona Ianosi, Adriana Socaci, Anca Dana Buzoianu, Teodora Gabriela Alexescu, Mihai Olteanu, Elena Rusu, Cosmin Alec Moldovan, Roxana Maria Nemes

Nocturnal Hypoxemia, a Key Parameter in Overlap Syndrome

Abstract:

The overlap syndrome (OS) is defined as a synergic relation between obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD). Patients with overlap syndrome present the clinical features of each disorder to a greater or a lesser extend depending on the predominant disease. We assessed the main differences between patients with OS and patients with OSA and we highlight the importance of nocturnal hypoxemia on clinical status and management of the patients with overlap syndrome, in order to simplify OSA screening tests in patients with COPD. The study population included 62 selected patients divided in two groups: the first group - subjects diagnosed with OS and the second group - subjects with OSA, without the diagnostic of COPD. The majority of the patients were male, with a mean age of 55±9.84 years in the OSA group and 65.5±10.32 years in the OS group. The nocturnal hypoxemia was more important in the OS grup, with 276.83 minutes spent at a SpO2 below 90% versus 132.98 minutes in the OSA group. The mean AHI was 57.7±29.244 events/hour of sleep in the OS group and 50.7±26.01 events/hour of sleep in the OSA group. At the diagnosis, the mean daytime SpO2 was 90.9±3.59% in the OS group and 95.9±1.57 % in the OSA group. There were statistically significant differences between the two groups concerning age, AHI, Epworth Slepiness Scale, nocturnal desaturation, medium and minimum SpO2 during sleep, daytime SpO2 at the diagnosis and at 1-year follow-up, the presence of cardiovascular comorbidities such as pulmonary hypertension and heart failure. Our study showed that patients with COPD have OSA predictors that differ from those usually recognise in the general population. In OS patients, the most important parameter is the nocturnal hypoxemia. So, it is very useful that the clinicians be trained to include in the management of selected obese COPD patients, comprehensive sleep history, sleep hygiene and OSA screening because, in clinical practice, OSA is quite often underdiagnosed in these patients.

Keywords:
COPD; OSA; overlap; AHI; desaturation

Issue: 2019, Volume 70, Issue 2

Pages: 449-454

Publication date: 2019/3/15

https://doi.org/10.37358/RC.19.2.6933

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BUDIN, C.E., MAIEREAN, A.D., IANOSI, E.S., SOCACI, A., BUZOIANU, A.D., ALEXESCU, T.G., OLTEANU, M., RUSU, E., MOLDOVAN, C.A., NEMES, R.M., Nocturnal Hypoxemia, a Key Parameter in Overlap Syndrome, Rev. Chim., 70(2), 2019, 449-454.

Vancouver
Budin CE, Maierean AD, Ianosi ES, Socaci A, Buzoianu AD, Alexescu TG, Olteanu M, Rusu E, Moldovan CA, Nemes RM. Nocturnal Hypoxemia, a Key Parameter in Overlap Syndrome. Rev. Chim.[internet]. 2019 Feb;70(2):449-454. Available from: https://doi.org/10.37358/RC.19.2.6933

APA 6th edition
Budin, C.E., Maierean, A.D., Ianosi, E.S., Socaci, A., Buzoianu, A.D., Alexescu, T.G.,... Nemes, R.M. (2019). Nocturnal Hypoxemia, a Key Parameter in Overlap Syndrome. Revista de Chimie, 70(2), 449-454. https://doi.org/10.37358/RC.19.2.6933

Harvard
Budin, C.E., Maierean, A.D., Ianosi, E.S., Socaci, A., Buzoianu, A.D., Alexescu, T.G., Olteanu, M., Rusu, E., Moldovan, C.A., Nemes, R.M. (2019). 'Nocturnal Hypoxemia, a Key Parameter in Overlap Syndrome', Revista de Chimie, 70(2), pp. 449-454. https://doi.org/10.37358/RC.19.2.6933

IEEE
C.E. Budin, A.D. Maierean, E.S. Ianosi, A. Socaci, A.D. Buzoianu, T.G. Alexescu, M. Olteanu, E. Rusu, C.A. Moldovan, R.M. Nemes, "Nocturnal Hypoxemia, a Key Parameter in Overlap Syndrome". Revista de Chimie, vol. 70, no. 2, pp. 449-454, 2019. [online]. https://doi.org/10.37358/RC.19.2.6933

Text
Corina Eugenia Budin, Anca Diana Maierean, Edith Simona Ianosi, Adriana Socaci, Anca Dana Buzoianu, Teodora Gabriela Alexescu, Mihai Olteanu, Elena Rusu, Cosmin Alec Moldovan, Roxana Maria Nemes,
Nocturnal Hypoxemia, a Key Parameter in Overlap Syndrome,
Revista de Chimie,
Volume 70, Issue 2,
2019,
Pages 449-454,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.2.6933.
(https://revistadechimie.ro/Articles.asp?ID=6933)
Keywords: COPD; OSA; overlap; AHI; desaturation

RIS
TY - JOUR
T1 - Nocturnal Hypoxemia, a Key Parameter in Overlap Syndrome
A1 - Budin, Corina Eugenia
A2 - Maierean, Anca Diana
A3 - Ianosi, Edith Simona
A4 - Socaci, Adriana
A5 - Buzoianu, Anca Dana
A6 - Alexescu, Teodora Gabriela
A7 - Olteanu, Mihai
A8 - Rusu, Elena
A9 - Moldovan, Cosmin Alec
A10 - Nemes, Roxana Maria
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 2
SP - 449
EP - 454
UR - https://doi.org/10.37358/RC.19.2.6933
KW - COPD
KW - OSA
KW - overlap
KW - AHI
KW - desaturation
ER -

BibTex
@article{RevCh2019P449,
author = {Budin Corina Eugenia and Maierean Anca Diana and Ianosi Edith Simona and Socaci Adriana and Buzoianu Anca Dana and Alexescu Teodora Gabriela and Olteanu Mihai and Rusu Elena and Moldovan Cosmin Alec and Nemes Roxana Maria},
title = {Nocturnal Hypoxemia, a Key Parameter in Overlap Syndrome},
journal = {Revista de Chimie},
volume = {70},
number = {2},
pages = {449-454},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.2.6933},
url = {https://revistadechimie.ro/Articles.asp?ID=6933}
}

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