HPLC-UV Determination of Dextromethorphan in Syrup Method validation

Avram, Nicolae; Heghes, Simona Codruta; Rus, Luca-Liviu; Juncan, Anca Maria; Rus, Lucia Maria; Filip, Lorena; Filip, Corina Roman

Nicolae Avram, Simona Codruta Heghes, Luca-Liviu Rus, Anca Maria Juncan, Lucia Maria Rus, Lorena Filip, Corina Roman Filip

HPLC-UV Determination of Dextromethorphan in Syrup Method validation

Abstract:

A HPLC-UV method, for determination of dextromethorphan hydrobromide in syrup, was validated. The chromatographic analysis was performed using an RP-18, Nucleodur chromatographic column (250 mm × 4 mm, 5 µm) at constant temperature (50oC) with a mobile phase consisting of a mixture of acetonitrile/methanol (70:30 v/v) with sodium docusate (as ion pair agent) and ammonium nitrate, pH = 3.4. The flow rate of the mobile phase was 1 mL/min and the detection was carried out at 280 nm. System suitability, specificity, linearity, precision, accuracy, limit of detection and limit of quantification agreed with current pharmacopeial requests. The method is suitable for routine analysis of dextromethorphan hydrobromide in syrup.

Keywords:
dextromethorphan; HPLC; validation; syrup

Issue: 2019, Volume 70, Issue 2

Pages: 487-490

Publication date: 2019/3/15

https://doi.org/10.37358/RC.19.2.6940

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
AVRAM, N., HEGHES, S.C., RUS, L., JUNCAN, A.M., RUS, L.M., FILIP, L., FILIP, C.R., HPLC-UV Determination of Dextromethorphan in Syrup Method validation, Rev. Chim., 70(2), 2019, 487-490.

Vancouver
Avram N, Heghes SC, Rus L, Juncan AM, Rus LM, Filip L, Filip CR. HPLC-UV Determination of Dextromethorphan in Syrup Method validation. Rev. Chim.[internet]. 2019 Feb;70(2):487-490. Available from: https://doi.org/10.37358/RC.19.2.6940

APA 6th edition
Avram, N., Heghes, S.C., Rus, L., Juncan, A.M., Rus, L.M., Filip, L. & Filip, C.R. (2019). HPLC-UV Determination of Dextromethorphan in Syrup Method validation. Revista de Chimie, 70(2), 487-490. https://doi.org/10.37358/RC.19.2.6940

Harvard
Avram, N., Heghes, S.C., Rus, L., Juncan, A.M., Rus, L.M., Filip, L., Filip, C.R. (2019). 'HPLC-UV Determination of Dextromethorphan in Syrup Method validation', Revista de Chimie, 70(2), pp. 487-490. https://doi.org/10.37358/RC.19.2.6940

IEEE
N. Avram, S.C. Heghes, L. Rus, A.M. Juncan, L.M. Rus, L. Filip, C.R. Filip, "HPLC-UV Determination of Dextromethorphan in Syrup Method validation". Revista de Chimie, vol. 70, no. 2, pp. 487-490, 2019. [online]. https://doi.org/10.37358/RC.19.2.6940

Text
Nicolae Avram, Simona Codruta Heghes, Luca-Liviu Rus, Anca Maria Juncan, Lucia Maria Rus, Lorena Filip, Corina Roman Filip,
HPLC-UV Determination of Dextromethorphan in Syrup Method validation,
Revista de Chimie,
Volume 70, Issue 2,
2019,
Pages 487-490,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.2.6940.
(https://revistadechimie.ro/Articles.asp?ID=6940)
Keywords: dextromethorphan; HPLC; validation; syrup

RIS
TY - JOUR
T1 - HPLC-UV Determination of Dextromethorphan in Syrup Method validation
A1 - Avram, Nicolae
A2 - Heghes, Simona Codruta
A3 - Rus, Luca-Liviu
A4 - Juncan, Anca Maria
A5 - Rus, Lucia Maria
A6 - Filip, Lorena
A7 - Filip, Corina Roman
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 2
SP - 487
EP - 490
UR - https://doi.org/10.37358/RC.19.2.6940
KW - dextromethorphan
KW - HPLC
KW - validation
KW - syrup
ER -

BibTex
@article{RevCh2019P487,
author = {Avram Nicolae and Heghes Simona Codruta and Rus Luca-Liviu and Juncan Anca Maria and Rus Lucia Maria and Filip Lorena and Filip Corina Roman},
title = {HPLC-UV Determination of Dextromethorphan in Syrup Method validation},
journal = {Revista de Chimie},
volume = {70},
number = {2},
pages = {487-490},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.2.6940},
url = {https://revistadechimie.ro/Articles.asp?ID=6940}
}

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