SIMONA IORDACHE, BOGDAN TUTUNARU, ADRIANA SAMIDE, ALEXANDRU POPESCU ELECTROCHEMICAL AND THERMAL STABILITY OF NYSTATIN DRUG
The analysis of synthetic / residual drugs is very important due to their systemic toxicity. Simple and rapid electrochemical degradation of nystatin drug was accomplished using constant current density electrolysis on platinum electrode. Electrochemical behavior of nystatin drug was investigated on different metallic electrodes by cyclic voltammetry. In saline solution, distinctive oxidation peak are observed on the lead and copper electrodes. The degree of electrochemical degradation reaches the maximum value of 100 % in 10 minutes on platinum electrodes. Thermal stability of nystatin drug was studied by simultaneous TG / DSC analysis. The thermogravimetric and heat flow curves indicated a relatively high stability up to 150 °C.