Cannabinoids: Chemical Structure, Mechanisms of Action, Toxicity and Implications in Everyday Life

Lupu, Mary Nicoleta; Miulescu, Magdalena; Sandu, Madalina Nina; Filip, Iulia; Rebegea, Laura; Ciobotaru, Octavian; Stoleriu, Gabriela; Earar, Kamel; Voinescu, Carina Doina; Ciobotaru, Oana Roxana

Mary Nicoleta Lupu, Magdalena Miulescu, Madalina Nina Sandu, Iulia Filip, Laura Rebegea, Octavian Ciobotaru, Gabriela Stoleriu, Kamel Earar, Carina Doina Voinescu, Oana Roxana Ciobotaru

Cannabinoids: Chemical Structure, Mechanisms of Action, Toxicity and Implications in Everyday Life

Abstract:

In the human body there is an endocannabinoid system consisting of cannabinoid receptors and endogenous transmitters - the endocannabinoids (anandamides).This cannabinoid system works by certain principles: the presynaptic neuron releases the neurotransmitter that reaches the postsynaptic neuron, activating it; at this level endocannabinoids are synthesized, whichhave retrograde transmission through the synaptic gap, reaching the cannabinoid receptors where they can inhibit the anterograde release of neurotransmitters. At the same level, certain exogenous substances, derived from plants and called phytocannabinoids may also work, the most known one being tetrahydrocannabinol. 9-D-Tetrahydrocannabinol is a component extracted from hemp plant with intense psychotic action but also with some medical applications. The result of the cannabinoid system activity is to obtain certain psychoactive effects, euphoria, relaxation, intense sensory experiences, pain relief but also changes in perception, attention deficit, etc. Synthetic cannabinoids are obtained to mimic the effects of marijuana, are major cannabinoid receptor agonists and are at increased risk of toxicity. Chronic consumption of such substances can cause memory disorders, pulmonary disorders and, most importantly, addiction.

Keywords:
cannabinoids; marihuana; anandamide; tetrahydrocannabinol; endocannabinoids; cyclooxigenase; ethnobotanics; COX2; adverse drug reactions

Issue: 2019, Volume 70, Issue 2

Pages: 627-629

Publication date: 2019/3/15

https://doi.org/10.37358/RC.19.2.6971

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
LUPU, M.N., MIULESCU, M., SANDU, M.N., FILIP, I., REBEGEA, L., CIOBOTARU, O., STOLERIU, G., EARAR, K., VOINESCU, C.D., CIOBOTARU, O.R., Cannabinoids: Chemical Structure, Mechanisms of Action, Toxicity and Implications in Everyday Life, Rev. Chim., 70(2), 2019, 627-629.

Vancouver
Lupu MN, Miulescu M, Sandu MN, Filip I, Rebegea L, Ciobotaru O, Stoleriu G, Earar K, Voinescu CD, Ciobotaru OR. Cannabinoids: Chemical Structure, Mechanisms of Action, Toxicity and Implications in Everyday Life. Rev. Chim.[internet]. 2019 Feb;70(2):627-629. Available from: https://doi.org/10.37358/RC.19.2.6971

APA 6th edition
Lupu, M.N., Miulescu, M., Sandu, M.N., Filip, I., Rebegea, L., Ciobotaru, O.,... Ciobotaru, O.R. (2019). Cannabinoids: Chemical Structure, Mechanisms of Action, Toxicity and Implications in Everyday Life. Revista de Chimie, 70(2), 627-629. https://doi.org/10.37358/RC.19.2.6971

Harvard
Lupu, M.N., Miulescu, M., Sandu, M.N., Filip, I., Rebegea, L., Ciobotaru, O., Stoleriu, G., Earar, K., Voinescu, C.D., Ciobotaru, O.R. (2019). 'Cannabinoids: Chemical Structure, Mechanisms of Action, Toxicity and Implications in Everyday Life', Revista de Chimie, 70(2), pp. 627-629. https://doi.org/10.37358/RC.19.2.6971

IEEE
M.N. Lupu, M. Miulescu, M.N. Sandu, I. Filip, L. Rebegea, O. Ciobotaru, G. Stoleriu, K. Earar, C.D. Voinescu, O.R. Ciobotaru, "Cannabinoids: Chemical Structure, Mechanisms of Action, Toxicity and Implications in Everyday Life". Revista de Chimie, vol. 70, no. 2, pp. 627-629, 2019. [online]. https://doi.org/10.37358/RC.19.2.6971

Text
Mary Nicoleta Lupu, Magdalena Miulescu, Madalina Nina Sandu, Iulia Filip, Laura Rebegea, Octavian Ciobotaru, Gabriela Stoleriu, Kamel Earar, Carina Doina Voinescu, Oana Roxana Ciobotaru,
Cannabinoids: Chemical Structure, Mechanisms of Action, Toxicity and Implications in Everyday Life,
Revista de Chimie,
Volume 70, Issue 2,
2019,
Pages 627-629,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.2.6971.
(https://revistadechimie.ro/Articles.asp?ID=6971)
Keywords: cannabinoids; marihuana; anandamide; tetrahydrocannabinol; endocannabinoids; cyclooxigenase; ethnobotanics; COX2; adverse drug reactions

RIS
TY - JOUR
T1 - Cannabinoids: Chemical Structure, Mechanisms of Action, Toxicity and Implications in Everyday Life
A1 - Lupu, Mary Nicoleta
A2 - Miulescu, Magdalena
A3 - Sandu, Madalina Nina
A4 - Filip, Iulia
A5 - Rebegea, Laura
A6 - Ciobotaru, Octavian
A7 - Stoleriu, Gabriela
A8 - Earar, Kamel
A9 - Voinescu, Carina Doina
A10 - Ciobotaru, Oana Roxana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 2
SP - 627
EP - 629
UR - https://doi.org/10.37358/RC.19.2.6971
KW - cannabinoids
KW - marihuana
KW - anandamide
KW - tetrahydrocannabinol
KW - endocannabinoids
KW - cyclooxigenase
KW - ethnobotanics
KW - COX2
KW - adverse drug reactions
ER -

BibTex
@article{RevCh2019P627,
author = {Lupu Mary Nicoleta and Miulescu Magdalena and Sandu Madalina Nina and Filip Iulia and Rebegea Laura and Ciobotaru Octavian and Stoleriu Gabriela and Earar Kamel and Voinescu Carina Doina and Ciobotaru Oana Roxana},
title = {Cannabinoids: Chemical Structure, Mechanisms of Action, Toxicity and Implications in Everyday Life},
journal = {Revista de Chimie},
volume = {70},
number = {2},
pages = {627-629},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.2.6971},
url = {https://revistadechimie.ro/Articles.asp?ID=6971}
}

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