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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 2, 630-632

https://doi.org/10.37358/RC.19.2.6972

Emilia Burada, Ileana Marinescu, Otilia Constantina Rogoveanu, Amelia-Mihaela Dobrescu, Cito Taisescu, Florin Burada, Veronica Sfredel, Tudor Adrian Balseanu

Vitamin B12 Blood Level is Correlated with Drug-Induced Extrapyramidal Symptoms in Schizophrenic Patients

Abstract:

The extrapyramidal symptoms (EPS) are commonly associated with antipsychotic treatment of schizophrenic patients. Accumulated evidence has shown that pathways of homocysteine and folate metabolism are linked to neurodegeneration and schizophrenia. The purpose of our study was to evaluate the homocysteine, vitamin B12 and folate serum levels in relation to drug-induced EPS in schizophrenic patients. The blood levels of homocysteine, vitamin B12 and folic acid were measured by chemiluminescent and electrochemoluminescence immunoassay methods in 34 patients diagnosed with schizophrenia (19 patients with severe EPS and 15 controls without EPS), recruited from Clinical Hospital of Neuropsychiatry Craiova, Romania. A significant association has been observed between EPS and vitamin B12 levels, the patients with severe EPS showed a reduced vitamin B12 levels (p=0.02). No correlation was observed between severe EPS and homocysteine or folate levels (p=0.2, respectively p=0.37). Our study suggests that deficiency of vitamin B12 blood levels is correlated with severe EPS in schizophrenic patients. Further studies included more patients and functional experiments are required to clarify the role of these biomarkers in relation with antipsychotic-induced EPS in schizophrenia.
Keywords:
extrapyramidal symptoms (EPS); schizophrenia; homocysteine; vitamin B12; folate

Issue: 2019, Volume 70, Issue 2
Pages: 630-632
Publication date: 2019/3/15
https://doi.org/10.37358/RC.19.2.6972
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
BURADA, E., MARINESCU, I., ROGOVEANU, O.C., DOBRESCU, A., TAISESCU, C., BURADA, F., SFREDEL, V., BALSEANU, T.A., Vitamin B12 Blood Level is Correlated with Drug-Induced Extrapyramidal Symptoms in Schizophrenic Patients, Rev. Chim., 70(2), 2019, 630-632.

Vancouver
Burada E, Marinescu I, Rogoveanu OC, Dobrescu A, Taisescu C, Burada F, Sfredel V, Balseanu TA. Vitamin B12 Blood Level is Correlated with Drug-Induced Extrapyramidal Symptoms in Schizophrenic Patients. Rev. Chim.[internet]. 2019 Feb;70(2):630-632. Available from: https://doi.org/10.37358/RC.19.2.6972


APA 6th edition
Burada, E., Marinescu, I., Rogoveanu, O.C., Dobrescu, A., Taisescu, C., Burada, F., Sfredel, V. & Balseanu, T.A. (2019). Vitamin B12 Blood Level is Correlated with Drug-Induced Extrapyramidal Symptoms in Schizophrenic Patients. Revista de Chimie, 70(2), 630-632. https://doi.org/10.37358/RC.19.2.6972


Harvard
Burada, E., Marinescu, I., Rogoveanu, O.C., Dobrescu, A., Taisescu, C., Burada, F., Sfredel, V., Balseanu, T.A. (2019). 'Vitamin B12 Blood Level is Correlated with Drug-Induced Extrapyramidal Symptoms in Schizophrenic Patients', Revista de Chimie, 70(2), pp. 630-632. https://doi.org/10.37358/RC.19.2.6972


IEEE
E. Burada, I. Marinescu, O.C. Rogoveanu, A. Dobrescu, C. Taisescu, F. Burada, V. Sfredel, T.A. Balseanu, "Vitamin B12 Blood Level is Correlated with Drug-Induced Extrapyramidal Symptoms in Schizophrenic Patients". Revista de Chimie, vol. 70, no. 2, pp. 630-632, 2019. [online]. https://doi.org/10.37358/RC.19.2.6972


Text
Emilia Burada, Ileana Marinescu, Otilia Constantina Rogoveanu, Amelia-Mihaela Dobrescu, Cito Taisescu, Florin Burada, Veronica Sfredel, Tudor Adrian Balseanu,
Vitamin B12 Blood Level is Correlated with Drug-Induced Extrapyramidal Symptoms in Schizophrenic Patients,
Revista de Chimie,
Volume 70, Issue 2,
2019,
Pages 630-632,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.2.6972.
(https://revistadechimie.ro/Articles.asp?ID=6972)
Keywords: extrapyramidal symptoms (EPS); schizophrenia; homocysteine; vitamin B12; folate


RIS
TY - JOUR
T1 - Vitamin B12 Blood Level is Correlated with Drug-Induced Extrapyramidal Symptoms in Schizophrenic Patients
A1 - Burada, Emilia
A2 - Marinescu, Ileana
A3 - Rogoveanu, Otilia Constantina
A4 - Dobrescu, Amelia-Mihaela
A5 - Taisescu, Cito
A6 - Burada, Florin
A7 - Sfredel, Veronica
A8 - Balseanu, Tudor Adrian
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 2
SP - 630
EP - 632
UR - https://doi.org/10.37358/RC.19.2.6972
KW - extrapyramidal symptoms (EPS)
KW - schizophrenia
KW - homocysteine
KW - vitamin B12
KW - folate
ER -


BibTex
@article{RevCh2019P630,
author = {Burada Emilia and Marinescu Ileana and Rogoveanu Otilia Constantina and Dobrescu Amelia-Mihaela and Taisescu Cito and Burada Florin and Sfredel Veronica and Balseanu Tudor Adrian},
title = {Vitamin B12 Blood Level is Correlated with Drug-Induced Extrapyramidal Symptoms in Schizophrenic Patients},
journal = {Revista de Chimie},
volume = {70},
number = {2},
pages = {630-632},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.2.6972},
url = {https://revistadechimie.ro/Articles.asp?ID=6972}
}
 
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