Tranexamic Acid - Major Antifibrinolytic Agent Used to Achieve Hemostasis in Hemophilic Patients with Anti-Factor VIII Anti-Bodies Who Must Undergo Total Joint Replecement

Badulescu, Oana Viola; Ciocoiu, Manuela; Filip, Nina; Veringa, Vlad

Oana Viola Badulescu, Manuela Ciocoiu, Nina Filip, Vlad Veringa

Tranexamic Acid - Major Antifibrinolytic Agent Used to Achieve Hemostasis in Hemophilic Patients with Anti-Factor VIII Anti-Bodies Who Must Undergo Total Joint Replecement

Abstract:

Hemophilia is a congenital coagulopathy characterized by a deficiency of coagulation factor VIII or IX. The main complication of this hemopathy is represented by the hemorrhagiparous phenomena that affect mainly the musculoskeletal system. Of the various chronic complications of this condition, hemarthrosis is responsible for the onset of chronic arthropathy, which is a disabling condition. In addition to hematologist-prescribed coagulation factor replacement therapy, acute hemarthrosis and chronic arthropathy management requires close collaboration with both orthopedic surgeons and physiotherapists. This multidisciplinary collaboration is essential both to prevent the onset of hemarthroses and to manage acute bleeding episodes, to assess joint function and to effectively treat hemophilic chronic arthropathy. Hemophilic arthropathy causes significant joint instability and reduced mobility or even total ankylosis, which may lead to permanent disability and hence to a decrease in the patient’s quality of life. From an orthopedic point of view, disabling hemophilic arthropathy may be treated by surgery. Achieving effective hemostasis is vital in order to be able to perform these extremely difficult surgical procedures, due to the high risk of bleeding. This paper aims at highlighting the hemostatic efficacy of tranexamic acid in orthopedic surgery in hemophilic patients who must undergo total joint replacement.

Keywords:
hemophilia; arthropathy; hemarthrosis; tranexamic acid

Issue: 2019, Volume 70, Issue 2

Pages: 638-641

Publication date: 2019/3/15

https://doi.org/10.37358/RC.19.2.6974

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BADULESCU, O.V., CIOCOIU, M., FILIP, N., VERINGA, V., Tranexamic Acid - Major Antifibrinolytic Agent Used to Achieve Hemostasis in Hemophilic Patients with Anti-Factor VIII Anti-Bodies Who Must Undergo Total Joint Replecement, Rev. Chim., 70(2), 2019, 638-641.

Vancouver
Badulescu OV, Ciocoiu M, Filip N, Veringa V. Tranexamic Acid - Major Antifibrinolytic Agent Used to Achieve Hemostasis in Hemophilic Patients with Anti-Factor VIII Anti-Bodies Who Must Undergo Total Joint Replecement. Rev. Chim.[internet]. 2019 Feb;70(2):638-641. Available from: https://doi.org/10.37358/RC.19.2.6974

APA 6th edition
Badulescu, O.V., Ciocoiu, M., Filip, N. & Veringa, V. (2019). Tranexamic Acid - Major Antifibrinolytic Agent Used to Achieve Hemostasis in Hemophilic Patients with Anti-Factor VIII Anti-Bodies Who Must Undergo Total Joint Replecement. Revista de Chimie, 70(2), 638-641. https://doi.org/10.37358/RC.19.2.6974

Harvard
Badulescu, O.V., Ciocoiu, M., Filip, N., Veringa, V. (2019). 'Tranexamic Acid - Major Antifibrinolytic Agent Used to Achieve Hemostasis in Hemophilic Patients with Anti-Factor VIII Anti-Bodies Who Must Undergo Total Joint Replecement', Revista de Chimie, 70(2), pp. 638-641. https://doi.org/10.37358/RC.19.2.6974

IEEE
O.V. Badulescu, M. Ciocoiu, N. Filip, V. Veringa, "Tranexamic Acid - Major Antifibrinolytic Agent Used to Achieve Hemostasis in Hemophilic Patients with Anti-Factor VIII Anti-Bodies Who Must Undergo Total Joint Replecement". Revista de Chimie, vol. 70, no. 2, pp. 638-641, 2019. [online]. https://doi.org/10.37358/RC.19.2.6974

Text
Oana Viola Badulescu, Manuela Ciocoiu, Nina Filip, Vlad Veringa,
Tranexamic Acid - Major Antifibrinolytic Agent Used to Achieve Hemostasis in Hemophilic Patients with Anti-Factor VIII Anti-Bodies Who Must Undergo Total Joint Replecement,
Revista de Chimie,
Volume 70, Issue 2,
2019,
Pages 638-641,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.2.6974.
(https://revistadechimie.ro/Articles.asp?ID=6974)
Keywords: hemophilia; arthropathy; hemarthrosis; tranexamic acid

RIS
TY - JOUR
T1 - Tranexamic Acid - Major Antifibrinolytic Agent Used to Achieve Hemostasis in Hemophilic Patients with Anti-Factor VIII Anti-Bodies Who Must Undergo Total Joint Replecement
A1 - Badulescu, Oana Viola
A2 - Ciocoiu, Manuela
A3 - Filip, Nina
A4 - Veringa, Vlad
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 2
SP - 638
EP - 641
UR - https://doi.org/10.37358/RC.19.2.6974
KW - hemophilia
KW - arthropathy
KW - hemarthrosis
KW - tranexamic acid
ER -

BibTex
@article{RevCh2019P638,
author = {Badulescu Oana Viola and Ciocoiu Manuela and Filip Nina and Veringa Vlad},
title = {Tranexamic Acid - Major Antifibrinolytic Agent Used to Achieve Hemostasis in Hemophilic Patients with Anti-Factor VIII Anti-Bodies Who Must Undergo Total Joint Replecement},
journal = {Revista de Chimie},
volume = {70},
number = {2},
pages = {638-641},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.2.6974},
url = {https://revistadechimie.ro/Articles.asp?ID=6974}
}

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