The Benefits and Risks of Antioxidant Treatment in Liver Diseases

Gheorghe, Gina; Stoian, Anca Pantea; Gaman, Mihnea-Alexandru; Socea, Bogdan; Neagu, Tiberiu Paul; Stanescu, Ana Maria Alexandra; Bratu, Ovidiu Gabriel; Mischianu, Dan Liviu Dorel; Suceveanu, Andra Iulia; Diaconu, Camelia Cristina

Gina Gheorghe, Anca Pantea Stoian, Mihnea-Alexandru Gaman, Bogdan Socea, Tiberiu Paul Neagu, Ana Maria Alexandra Stanescu, Ovidiu Gabriel Bratu, Dan Liviu Dorel Mischianu, Andra Iulia Suceveanu, Camelia Cristina Diaconu

The Benefits and Risks of Antioxidant Treatment in Liver Diseases

Abstract:

Chronic liver diseases are a public health issue, because of their high incidence and prevalence, the important impact on the quality of life and high mortality rates. From a pathogenic point of view, in almost all liver diseases there is an increase in oxidative stress. Oxidative stress represents as an imbalance between the production of oxidizing agents and antioxidants. This imbalance contributes to the initiation and progression of hepatic injury. Among the most important risk factors for increased oxidative stress in chronic liver diseases are alcohol, drugs, environmental pollutants and irradiation. For the restoration of the oxidant-antioxidant balance and reduction of the oxidative stress in chronic liver diseases, a promising role may have the antioxidants. This hypothesis is now based on experimental evidence of their efficacy in animal models. In low concentrations, antioxidants improve liver function by preventing the oxidation of an oxidizable substrate, but in high doses, they may cause adverse reactions, such as the pro-oxidant effect, glutathione S transferase inhibition and thus the inhibition of detoxification and interference with coagulation. The objective of the article is to review the benefits of antioxidant treatment in chronic diseases of the liver, in order to put them in balance with their adverse reactions.

Keywords:
chronic liver diseases; antioxidant treatment; silymarin; resveratrol; vitamin A

Issue: 2019, Volume 70, Issue 2

Pages: 651-655

Publication date: 2019/3/15

https://doi.org/10.37358/RC.19.2.6977

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
GHEORGHE, G., STOIAN, A.P., GAMAN, M., SOCEA, B., NEAGU, T.P., STANESCU, A.M.A., BRATU, O.G., MISCHIANU, D.L.D., SUCEVEANU, A.I., DIACONU, C.C., The Benefits and Risks of Antioxidant Treatment in Liver Diseases, Rev. Chim., 70(2), 2019, 651-655.

Vancouver
Gheorghe G, Stoian AP, Gaman M, Socea B, Neagu TP, Stanescu AMA, Bratu OG, Mischianu DLD, Suceveanu AI, Diaconu CC. The Benefits and Risks of Antioxidant Treatment in Liver Diseases. Rev. Chim.[internet]. 2019 Feb;70(2):651-655. Available from: https://doi.org/10.37358/RC.19.2.6977

APA 6th edition
Gheorghe, G., Stoian, A.P., Gaman, M., Socea, B., Neagu, T.P., Stanescu, A.M.A.,... Diaconu, C.C. (2019). The Benefits and Risks of Antioxidant Treatment in Liver Diseases. Revista de Chimie, 70(2), 651-655. https://doi.org/10.37358/RC.19.2.6977

Harvard
Gheorghe, G., Stoian, A.P., Gaman, M., Socea, B., Neagu, T.P., Stanescu, A.M.A., Bratu, O.G., Mischianu, D.L.D., Suceveanu, A.I., Diaconu, C.C. (2019). 'The Benefits and Risks of Antioxidant Treatment in Liver Diseases', Revista de Chimie, 70(2), pp. 651-655. https://doi.org/10.37358/RC.19.2.6977

IEEE
G. Gheorghe, A.P. Stoian, M. Gaman, B. Socea, T.P. Neagu, A.M.A. Stanescu, O.G. Bratu, D.L.D. Mischianu, A.I. Suceveanu, C.C. Diaconu, "The Benefits and Risks of Antioxidant Treatment in Liver Diseases". Revista de Chimie, vol. 70, no. 2, pp. 651-655, 2019. [online]. https://doi.org/10.37358/RC.19.2.6977

Text
Gina Gheorghe, Anca Pantea Stoian, Mihnea-Alexandru Gaman, Bogdan Socea, Tiberiu Paul Neagu, Ana Maria Alexandra Stanescu, Ovidiu Gabriel Bratu, Dan Liviu Dorel Mischianu, Andra Iulia Suceveanu, Camelia Cristina Diaconu,
The Benefits and Risks of Antioxidant Treatment in Liver Diseases,
Revista de Chimie,
Volume 70, Issue 2,
2019,
Pages 651-655,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.2.6977.
(https://revistadechimie.ro/Articles.asp?ID=6977)
Keywords: chronic liver diseases; antioxidant treatment; silymarin; resveratrol; vitamin A

RIS
TY - JOUR
T1 - The Benefits and Risks of Antioxidant Treatment in Liver Diseases
A1 - Gheorghe, Gina
A2 - Stoian, Anca Pantea
A3 - Gaman, Mihnea-Alexandru
A4 - Socea, Bogdan
A5 - Neagu, Tiberiu Paul
A6 - Stanescu, Ana Maria Alexandra
A7 - Bratu, Ovidiu Gabriel
A8 - Mischianu, Dan Liviu Dorel
A9 - Suceveanu, Andra Iulia
A10 - Diaconu, Camelia Cristina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 2
SP - 651
EP - 655
UR - https://doi.org/10.37358/RC.19.2.6977
KW - chronic liver diseases
KW - antioxidant treatment
KW - silymarin
KW - resveratrol
KW - vitamin A
ER -

BibTex
@article{RevCh2019P651,
author = {Gheorghe Gina and Stoian Anca Pantea and Gaman Mihnea-Alexandru and Socea Bogdan and Neagu Tiberiu Paul and Stanescu Ana Maria Alexandra and Bratu Ovidiu Gabriel and Mischianu Dan Liviu Dorel and Suceveanu Andra Iulia and Diaconu Camelia Cristina},
title = {The Benefits and Risks of Antioxidant Treatment in Liver Diseases},
journal = {Revista de Chimie},
volume = {70},
number = {2},
pages = {651-655},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.2.6977},
url = {https://revistadechimie.ro/Articles.asp?ID=6977}
}

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