GABRIEL MARC, SMARANDA ONIGA, ADRIAN PIRNAU, MIHAELA DUMA, LAURIAN VLASE5, OVIDIU ONIGA RATIONAL SYNTHESIS OF SOME NEW PARA-AMINOBENZOIC ACID HYBRIDS WITH THIAZOLIDIN-2,4-DIONES WITH ANTIMICROBIAL PROPERTIES ADMET AND MOLECULAR DOCKING EVALUATION
The present paper presents the synthesis, physicochemical characterization, in vitro antimicrobial activity and the molecular docking study of a series of ten new thiazolidine-2,4-dione derivatives conjugated to para-aminobenzoic acid (PABA). The lipophilicity of the new molecules was evaluated in silico. Quantitative elemental C, H, N, S analysis and spectral data (mass spectrometry, infrared and nuclear magnetic resonance) were consistent with the expected data. The results of the antimicrobial activity screening revealed that some of the synthesized compounds had moderate to good activity against E. coli ATCC 25922, S. aureus, ATCC 6538P and C. albicans ATCC 10231.