Rational Synthesis of Some New para-Aminobenzoic Acid Hybrids with Thiazolidin-2,4-diones with Antimicrobial Properties. ADMET and molecular docking evaluation

Marc, Gabriel; Oniga, Smaranda; Pirnau, Adrian; Duma, Mihaela; Vlase, Laurian; Oniga, Ovidiu

Gabriel Marc, Smaranda Oniga, Adrian Pirnau, Mihaela Duma, Laurian Vlase, Ovidiu Oniga

Rational Synthesis of Some New para-Aminobenzoic Acid Hybrids with Thiazolidin-2,4-diones with Antimicrobial Properties. ADMET and molecular docking evaluation

Abstract:

The present paper presents the synthesis, physicochemical characterization, in vitro antimicrobial activity and the molecular docking study of a series of ten new thiazolidine-2,4-dione derivatives conjugated to para-aminobenzoic acid (PABA). The lipophilicity of the new molecules was evaluated in silico. Quantitative elemental C, H, N, S analysis and spectral data (mass spectrometry, infrared and nuclear magnetic resonance) were consistent with the expected data. The results of the antimicrobial activity screening revealed that some of the synthesized compounds had moderate to good activity against E. coli ATCC 25922, S. aureus, ATCC 6538P and C. albicans ATCC 10231.

Keywords:
thiazolidine-2;4-dione; para-amino benzoic acid; antimicrobial; docking

Issue: 2019, Volume 70, Issue 3

Pages: 769-775

Publication date: 2019/4/15

https://doi.org/10.37358/RC.19.3.7004

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MARC, G., ONIGA, S., PIRNAU, A., DUMA, M., VLASE, L., ONIGA, O., Rational Synthesis of Some New para-Aminobenzoic Acid Hybrids with Thiazolidin-2,4-diones with Antimicrobial Properties. ADMET and molecular docking evaluation, Rev. Chim., 70(3), 2019, 769-775.

Vancouver
Marc G, Oniga S, Pirnau A, Duma M, Vlase L, Oniga O. Rational Synthesis of Some New para-Aminobenzoic Acid Hybrids with Thiazolidin-2,4-diones with Antimicrobial Properties. ADMET and molecular docking evaluation. Rev. Chim.[internet]. 2019 Mar;70(3):769-775. Available from: https://doi.org/10.37358/RC.19.3.7004

APA 6th edition
Marc, G., Oniga, S., Pirnau, A., Duma, M., Vlase, L. & Oniga, O. (2019). Rational Synthesis of Some New para-Aminobenzoic Acid Hybrids with Thiazolidin-2,4-diones with Antimicrobial Properties. ADMET and molecular docking evaluation. Revista de Chimie, 70(3), 769-775. https://doi.org/10.37358/RC.19.3.7004

Harvard
Marc, G., Oniga, S., Pirnau, A., Duma, M., Vlase, L., Oniga, O. (2019). 'Rational Synthesis of Some New para-Aminobenzoic Acid Hybrids with Thiazolidin-2,4-diones with Antimicrobial Properties. ADMET and molecular docking evaluation', Revista de Chimie, 70(3), pp. 769-775. https://doi.org/10.37358/RC.19.3.7004

IEEE
G. Marc, S. Oniga, A. Pirnau, M. Duma, L. Vlase, O. Oniga, "Rational Synthesis of Some New para-Aminobenzoic Acid Hybrids with Thiazolidin-2,4-diones with Antimicrobial Properties. ADMET and molecular docking evaluation". Revista de Chimie, vol. 70, no. 3, pp. 769-775, 2019. [online]. https://doi.org/10.37358/RC.19.3.7004

Text
Gabriel Marc, Smaranda Oniga, Adrian Pirnau, Mihaela Duma, Laurian Vlase, Ovidiu Oniga,
Rational Synthesis of Some New para-Aminobenzoic Acid Hybrids with Thiazolidin-2,4-diones with Antimicrobial Properties. ADMET and molecular docking evaluation,
Revista de Chimie,
Volume 70, Issue 3,
2019,
Pages 769-775,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.3.7004.
(https://revistadechimie.ro/Articles.asp?ID=7004)
Keywords: thiazolidine-2;4-dione; para-amino benzoic acid; antimicrobial; docking

RIS
TY - JOUR
T1 - Rational Synthesis of Some New para-Aminobenzoic Acid Hybrids with Thiazolidin-2,4-diones with Antimicrobial Properties. ADMET and molecular docking evaluation
A1 - Marc, Gabriel
A2 - Oniga, Smaranda
A3 - Pirnau, Adrian
A4 - Duma, Mihaela
A5 - Vlase, Laurian
A6 - Oniga, Ovidiu
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 3
SP - 769
EP - 775
UR - https://doi.org/10.37358/RC.19.3.7004
KW - thiazolidine-2
KW - 4-dione
KW - para-amino benzoic acid
KW - antimicrobial
KW - docking
ER -

BibTex
@article{RevCh2019P769,
author = {Marc Gabriel and Oniga Smaranda and Pirnau Adrian and Duma Mihaela and Vlase Laurian and Oniga Ovidiu},
title = {Rational Synthesis of Some New para-Aminobenzoic Acid Hybrids with Thiazolidin-2,4-diones with Antimicrobial Properties. ADMET and molecular docking evaluation},
journal = {Revista de Chimie},
volume = {70},
number = {3},
pages = {769-775},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.3.7004},
url = {https://revistadechimie.ro/Articles.asp?ID=7004}
}

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