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REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 3, 814-819

https://doi.org/10.37358/RC.19.3.7013

Luciana Teodora Rotaru, Paul Nedelea, Renata-Maria Varut, Alina Petrica, Silvia Nica, Catalin Bouros, Diana Cimpoesu, Mihaela Corlade, Mihai Banicioiu Covei, Marius Novac

Determining the Influence of Alcohol on the Pharmacological Effect of Benzodiazepines by Molecular Docking Tehnique

Abstract:

Benzodiazepines represents a large category of medications that were originally developed to treat anxiety disorders or issues with anxiety, seizures, and issues with sleeping. The most common drugs abused along with benzodiazepines are other benzodiazepines, prescription pain medications and alcohol. Alcohol and benzodiazepine have a synergistic depressant effect on the central nervous system. Combining alcohol with benzodiazepines can be dangerous practice even if it is engaged in only occasionally. In the present study, using molecular docking technique we followed the binding energy of benzodiazepines with benzodiazepine receptor and efficacy of the flumazenil antidote against benzodiazepine in the presence and absence of alcohol. We realized correlation study of molecular descriptors value of benzodiazepines with benzodiazepine-GABAA complex binding energy.
Keywords:
molecular docking; molecular descriptors; benzodiazepines; procedural sedation; neuroleptanalgesia

Issue: 2019, Volume 70, Issue 3
Pages: 814-819
Publication date: 2019/4/15
https://doi.org/10.37358/RC.19.3.7013
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
ROTARU, L.T., NEDELEA, P., VARUT, R., PETRICA, A., NICA, S., BOUROS, C., CIMPOESU, D., CORLADE, M., COVEI, M.B., NOVAC, M., Determining the Influence of Alcohol on the Pharmacological Effect of Benzodiazepines by Molecular Docking Tehnique, Rev. Chim., 70(3), 2019, 814-819.

Vancouver
Rotaru LT, Nedelea P, Varut R, Petrica A, Nica S, Bouros C, Cimpoesu D, Corlade M, Covei MB, Novac M. Determining the Influence of Alcohol on the Pharmacological Effect of Benzodiazepines by Molecular Docking Tehnique. Rev. Chim.[internet]. 2019 Mar;70(3):814-819. Available from: https://doi.org/10.37358/RC.19.3.7013


APA 6th edition
Rotaru, L.T., Nedelea, P., Varut, R., Petrica, A., Nica, S., Bouros, C.,... Novac, M. (2019). Determining the Influence of Alcohol on the Pharmacological Effect of Benzodiazepines by Molecular Docking Tehnique. Revista de Chimie, 70(3), 814-819. https://doi.org/10.37358/RC.19.3.7013


Harvard
Rotaru, L.T., Nedelea, P., Varut, R., Petrica, A., Nica, S., Bouros, C., Cimpoesu, D., Corlade, M., Covei, M.B., Novac, M. (2019). 'Determining the Influence of Alcohol on the Pharmacological Effect of Benzodiazepines by Molecular Docking Tehnique', Revista de Chimie, 70(3), pp. 814-819. https://doi.org/10.37358/RC.19.3.7013


IEEE
L.T. Rotaru, P. Nedelea, R. Varut, A. Petrica, S. Nica, C. Bouros, D. Cimpoesu, M. Corlade, M.B. Covei, M. Novac, "Determining the Influence of Alcohol on the Pharmacological Effect of Benzodiazepines by Molecular Docking Tehnique". Revista de Chimie, vol. 70, no. 3, pp. 814-819, 2019. [online]. https://doi.org/10.37358/RC.19.3.7013


Text
Luciana Teodora Rotaru, Paul Nedelea, Renata-Maria Varut, Alina Petrica, Silvia Nica, Catalin Bouros, Diana Cimpoesu, Mihaela Corlade, Mihai Banicioiu Covei, Marius Novac,
Determining the Influence of Alcohol on the Pharmacological Effect of Benzodiazepines by Molecular Docking Tehnique,
Revista de Chimie,
Volume 70, Issue 3,
2019,
Pages 814-819,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.3.7013.
(https://revistadechimie.ro/Articles.asp?ID=7013)
Keywords: molecular docking; molecular descriptors; benzodiazepines; procedural sedation; neuroleptanalgesia


RIS
TY - JOUR
T1 - Determining the Influence of Alcohol on the Pharmacological Effect of Benzodiazepines by Molecular Docking Tehnique
A1 - Rotaru, Luciana Teodora
A2 - Nedelea, Paul
A3 - Varut, Renata-Maria
A4 - Petrica, Alina
A5 - Nica, Silvia
A6 - Bouros, Catalin
A7 - Cimpoesu, Diana
A8 - Corlade, Mihaela
A9 - Covei, Mihai Banicioiu
A10 - Novac, Marius
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 3
SP - 814
EP - 819
UR - https://doi.org/10.37358/RC.19.3.7013
KW - molecular docking
KW - molecular descriptors
KW - benzodiazepines
KW - procedural sedation
KW - neuroleptanalgesia
ER -


BibTex
@article{RevCh2019P814,
author = {Rotaru Luciana Teodora and Nedelea Paul and Varut Renata-Maria and Petrica Alina and Nica Silvia and Bouros Catalin and Cimpoesu Diana and Corlade Mihaela and Covei Mihai Banicioiu and Novac Marius},
title = {Determining the Influence of Alcohol on the Pharmacological Effect of Benzodiazepines by Molecular Docking Tehnique},
journal = {Revista de Chimie},
volume = {70},
number = {3},
pages = {814-819},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.3.7013},
url = {https://revistadechimie.ro/Articles.asp?ID=7013}
}
 
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