Assessment of Serum Cystatin C as an Early Biomarker of Carotid Atherosclerosis

Grigoras, Mirela; Lighezan, Daniel; Folescu, Roxana; Faur, Cosmin Ioan; Dejica, Simina; Nicola, Patricia; Dahma, George; Baaj, Teim; Tilea, Ioan; Varga, Andreea; Ardeleanu, Elena; Pascu, Alina Mihaela; Poroch, Vladimir; Gurgus, Daniela

Mirela Grigoras, Daniel Lighezan, Roxana Folescu, Cosmin Ioan Faur, Simina Dejica, Patricia Nicola, George Dahma, Teim Baaj, Ioan Tilea, Andreea Varga, Elena Ardeleanu, Alina Mihaela Pascu, Vladimir Poroch, Daniela Gurgus

Assessment of Serum Cystatin C as an Early Biomarker of Carotid Atherosclerosis

Abstract:

The aim of this study was to establish the correlation between the value of serum cystatin C (Cys C) and carotid atherosclerosis in patients without chronic kidney disease and to determine the serum Cys C cut-off level for carotid atherosclerosis diagnosis. The study was performed between October 2014 and June 2018, and included 256 patients from 20 family medicine offices of Timis County, both from urban and rural areas. The patients completed a socio-demographic questionnaire, and were clinically examined by their general practitioner and investigated by laboratory tests and carotid ultrasound. The mean age of the patients with high serum Cys C (study group 1) was 74 years (82% male), while in study group 2 (with low serum Cys C values) the mean age was 56 years old (63% male). Cys C levels were significantly correlated with serum creatinine and estimated glomerular filtration rate. In the group with elevated levels of Cys C we found an increased incidence of obesity, hypertension, diabetes and carotid atherosclerosis. Multivariate analysis showed that the increased levels of Cys C were associated with a maximum carotid plaque thickness (MCPT) ³2 mm (OR: 2.86, 95% C.I.: 1.13-7.97). The serum Cys C cut-off level for the diagnosis of atherosclerosis determined by ROC (receiver operating characteristic) curve was 0.73 mg/dL.

Keywords:
Cystatin C; atherosclerosis; maximum carotid plaque thickness

Issue: 2019, Volume 70, Issue 3

Pages: 984-989

Publication date: 2019/4/15

https://doi.org/10.37358/RC.19.3.7045

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
GRIGORAS, M., LIGHEZAN, D., FOLESCU, R., FAUR, C.I., DEJICA, S., NICOLA, P., DAHMA, G., BAAJ, T., TILEA, I., VARGA, A., ARDELEANU, E., PASCU, A.M., POROCH, V., GURGUS, D., Assessment of Serum Cystatin C as an Early Biomarker of Carotid Atherosclerosis, Rev. Chim., 70(3), 2019, 984-989.

Vancouver
Grigoras M, Lighezan D, Folescu R, Faur CI, Dejica S, Nicola P, Dahma G, Baaj T, Tilea I, Varga A, Ardeleanu E, Pascu AM, Poroch V, Gurgus D. Assessment of Serum Cystatin C as an Early Biomarker of Carotid Atherosclerosis. Rev. Chim.[internet]. 2019 Mar;70(3):984-989. Available from: https://doi.org/10.37358/RC.19.3.7045

APA 6th edition
Grigoras, M., Lighezan, D., Folescu, R., Faur, C.I., Dejica, S., Nicola, P.,... Gurgus, D. (2019). Assessment of Serum Cystatin C as an Early Biomarker of Carotid Atherosclerosis. Revista de Chimie, 70(3), 984-989. https://doi.org/10.37358/RC.19.3.7045

Harvard
Grigoras, M., Lighezan, D., Folescu, R., Faur, C.I., Dejica, S., Nicola, P., Dahma, G., Baaj, T., Tilea, I., Varga, A., Ardeleanu, E., Pascu, A.M., Poroch, V., Gurgus, D. (2019). 'Assessment of Serum Cystatin C as an Early Biomarker of Carotid Atherosclerosis', Revista de Chimie, 70(3), pp. 984-989. https://doi.org/10.37358/RC.19.3.7045

IEEE
M. Grigoras, D. Lighezan, R. Folescu, C.I. Faur, S. Dejica, P. Nicola, G. Dahma, T. Baaj, I. Tilea, A. Varga, E. Ardeleanu, A.M. Pascu, V. Poroch, D. Gurgus, "Assessment of Serum Cystatin C as an Early Biomarker of Carotid Atherosclerosis". Revista de Chimie, vol. 70, no. 3, pp. 984-989, 2019. [online]. https://doi.org/10.37358/RC.19.3.7045

Text
Mirela Grigoras, Daniel Lighezan, Roxana Folescu, Cosmin Ioan Faur, Simina Dejica, Patricia Nicola, George Dahma, Teim Baaj, Ioan Tilea, Andreea Varga, Elena Ardeleanu, Alina Mihaela Pascu, Vladimir Poroch, Daniela Gurgus,
Assessment of Serum Cystatin C as an Early Biomarker of Carotid Atherosclerosis,
Revista de Chimie,
Volume 70, Issue 3,
2019,
Pages 984-989,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.3.7045.
(https://revistadechimie.ro/Articles.asp?ID=7045)
Keywords: Cystatin C; atherosclerosis; maximum carotid plaque thickness

RIS
TY - JOUR
T1 - Assessment of Serum Cystatin C as an Early Biomarker of Carotid Atherosclerosis
A1 - Grigoras, Mirela
A2 - Lighezan, Daniel
A3 - Folescu, Roxana
A4 - Faur, Cosmin Ioan
A5 - Dejica, Simina
A6 - Nicola, Patricia
A7 - Dahma, George
A8 - Baaj, Teim
A9 - Tilea, Ioan
A10 - Varga, Andreea
A11 - Ardeleanu, Elena
A12 - Pascu, Alina Mihaela
A13 - Poroch, Vladimir
A14 - Gurgus, Daniela
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 3
SP - 984
EP - 989
UR - https://doi.org/10.37358/RC.19.3.7045
KW - Cystatin C; atherosclerosis; maximum carotid plaque thickness
ER -

BibTex
@article{RevCh2019P984,
author = {Grigoras Mirela and Lighezan Daniel and Folescu Roxana and Faur Cosmin Ioan and Dejica Simina and Nicola Patricia and Dahma George and Baaj Teim and Tilea Ioan and Varga Andreea and Ardeleanu Elena and Pascu Alina Mihaela and Poroch Vladimir and Gurgus Daniela},
title = {Assessment of Serum Cystatin C as an Early Biomarker of Carotid Atherosclerosis},
journal = {Revista de Chimie},
volume = {70},
number = {3},
pages = {984-989},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.3.7045},
url = {https://revistadechimie.ro/Articles.asp?ID=7045}
}

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