The Impact of Assisted Reproduction on First Trimester Biochemical Markers in Singleton and Twin Pregnancies

Albu, Dragos; Sima, Romina Marina; Ples, Liana; Ionescu, Antoniu Cringu; Dimitriu, Mihai; Popescu, Mihai; Moisei, Cristina; Nicolae, Camelia; Cobelschi, Calin; Calin, Alina; Neacsu, Adrian

Dragos Albu, Romina Marina Sima, Liana Ples, Antoniu Cringu Ionescu, Mihai Dimitriu, Mihai Popescu, Cristina Moisei, Camelia Nicolae, Calin Cobelschi, Alina Calin, Adrian Neacsu

The Impact of Assisted Reproduction on First Trimester Biochemical Markers in Singleton and Twin Pregnancies

Abstract:

The objective was to determine the effect of in vitro fertilization (IVF) on nuchal translucency, free beta-human chorionic gonadotropin (Free b-HCG) and pregnancy-associated plasma protein-A (Papp-A) measurements for singleton and twin pregnancies. This was a retrospective population-based register study that included 2921women with 11-13 weeks of gestation singleton and twin pregnancies. All patients were evaluated for the first trimester Down syndrome combined screening. We identify the effect of assisted reproductive technologies (ART) such as in vitro fertilization (IVF) on the nuchal translucency (NT), free beta-human chorionic gonadotropin (b-HCG) and pregnancy-associated plasma protein-A (PAPP-A) values. The study included 2921 patients: 2526 with spontaneous conception (86.5%) and 395 following IVF (13.5%); in our study singleton pregnancies were 2660 (91.1%), dichorionic twin pregnancies 232 (7.9%) and 12 (0.4%) monochorionic twin pregnancies. The mean b-HCG were about 56.67 IU/l (95%CI: 54.98-58.36) in singleton pregnancies and 128.08 IU/l (95%CI: 115.72-140.45) in twin pregnancies. PAPP-A mean values in singleton pregnancies were 3.54 IU/l (95%CI: 3.42-3.66) and 5.25 IU/l (95%CI: 4.46-6.08) in twin pregnancies. The results were statistically significant with p value p£01. There were also significant differences between b-HCG values in spontaneous pregnancies HCG 63.35 IU/l (95%CI: 60.14-64.10) and IVF pregnancies HCG 99.9 IU/l (95%CI: 91.8-107.99) with p value p £ 0.01. In our study the IVF had no impact on nuchal translucency values. Free b-HCG levels were higher in twin pregnancies and IVF pregnancies. PAPP-A concentrations were exceeded in twin pregnancies.

Keywords:
in vitro fertilization; pregnancy-associated plasma protein-A;beta-human chorionic gonadotropin

Issue: 2019, Volume 70, Issue 3

Pages: 1040-1044

Publication date: 2019/4/15

https://doi.org/10.37358/RC.19.3.7059

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ALBU, D., SIMA, R.M., PLES, L., IONESCU, A.C., DIMITRIU, M., POPESCU, M., MOISEI, C., NICOLAE, C., COBELSCHI, C., CALIN, A., NEACSU, A., The Impact of Assisted Reproduction on First Trimester Biochemical Markers in Singleton and Twin Pregnancies, Rev. Chim., 70(3), 2019, 1040-1044.

Vancouver
Albu D, Sima RM, Ples L, Ionescu AC, Dimitriu M, Popescu M, Moisei C, Nicolae C, Cobelschi C, Calin A, Neacsu A. The Impact of Assisted Reproduction on First Trimester Biochemical Markers in Singleton and Twin Pregnancies. Rev. Chim.[internet]. 2019 Mar;70(3):1040-1044. Available from: https://doi.org/10.37358/RC.19.3.7059

APA 6th edition
Albu, D., Sima, R.M., Ples, L., Ionescu, A.C., Dimitriu, M., Popescu, M.,... Neacsu, A. (2019). The Impact of Assisted Reproduction on First Trimester Biochemical Markers in Singleton and Twin Pregnancies. Revista de Chimie, 70(3), 1040-1044. https://doi.org/10.37358/RC.19.3.7059

Harvard
Albu, D., Sima, R.M., Ples, L., Ionescu, A.C., Dimitriu, M., Popescu, M., Moisei, C., Nicolae, C., Cobelschi, C., Calin, A., Neacsu, A. (2019). 'The Impact of Assisted Reproduction on First Trimester Biochemical Markers in Singleton and Twin Pregnancies', Revista de Chimie, 70(3), pp. 1040-1044. https://doi.org/10.37358/RC.19.3.7059

IEEE
D. Albu, R.M. Sima, L. Ples, A.C. Ionescu, M. Dimitriu, M. Popescu, C. Moisei, C. Nicolae, C. Cobelschi, A. Calin, A. Neacsu, "The Impact of Assisted Reproduction on First Trimester Biochemical Markers in Singleton and Twin Pregnancies". Revista de Chimie, vol. 70, no. 3, pp. 1040-1044, 2019. [online]. https://doi.org/10.37358/RC.19.3.7059

Text
Dragos Albu, Romina Marina Sima, Liana Ples, Antoniu Cringu Ionescu, Mihai Dimitriu, Mihai Popescu, Cristina Moisei, Camelia Nicolae, Calin Cobelschi, Alina Calin, Adrian Neacsu,
The Impact of Assisted Reproduction on First Trimester Biochemical Markers in Singleton and Twin Pregnancies,
Revista de Chimie,
Volume 70, Issue 3,
2019,
Pages 1040-1044,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.3.7059.
(https://revistadechimie.ro/Articles.asp?ID=7059)
Keywords: in vitro fertilization; pregnancy-associated plasma protein-A;beta-human chorionic gonadotropin

RIS
TY - JOUR
T1 - The Impact of Assisted Reproduction on First Trimester Biochemical Markers in Singleton and Twin Pregnancies
A1 - Albu, Dragos
A2 - Sima, Romina Marina
A3 - Ples, Liana
A4 - Ionescu, Antoniu Cringu
A5 - Dimitriu, Mihai
A6 - Popescu, Mihai
A7 - Moisei, Cristina
A8 - Nicolae, Camelia
A9 - Cobelschi, Calin
A10 - Calin, Alina
A11 - Neacsu, Adrian
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 3
SP - 1040
EP - 1044
UR - https://doi.org/10.37358/RC.19.3.7059
KW - in vitro fertilization
KW - pregnancy-associated plasma protein-A
KW - beta-human chorionic gonadotropin
ER -

BibTex
@article{RevCh2019P1040,
author = {Albu Dragos and Sima Romina Marina and Ples Liana and Ionescu Antoniu Cringu and Dimitriu Mihai and Popescu Mihai and Moisei Cristina and Nicolae Camelia and Cobelschi Calin and Calin Alina and Neacsu Adrian},
title = {The Impact of Assisted Reproduction on First Trimester Biochemical Markers in Singleton and Twin Pregnancies},
journal = {Revista de Chimie},
volume = {70},
number = {3},
pages = {1040-1044},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.3.7059},
url = {https://revistadechimie.ro/Articles.asp?ID=7059}
}

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