The Role of Antithrombin III in the Pathogenesis of the Thrombotic Status in Type 2 Diabetes Mellitus

Bararu-Bojan, Iris; Vladeanu (Apavaloaie), Maria Cristina; Bojan, Andrei; Sirbu, Paul-Dan; Ciocoiu, Manuela; Badulescu, Oana

Iris Bararu-Bojan, Maria Cristina Vladeanu (Apavaloaie), Andrei Bojan, Paul-Dan Sirbu, Manuela Ciocoiu, Oana Badulescu

The Role of Antithrombin III in the Pathogenesis of the Thrombotic Status in Type 2 Diabetes Mellitus

Abstract:

Diabetes mellitus is one of the costliest chronic pathology worldwide with a continuous rising incidence. Diabetes mellitus is linked to frequent cardiovascular events. It is associated with vascular events, especially when the glycated hemoglobin has elevated values. Diabetic patients seem to develop abnormalities of the haemostatic process, such as alterations of the thrombocytic function, modifications of the coagulation and of the fibrinolysis that lead to a thrombophillic status. The acquired thrombophilia present in diabetic patients may be due to the non-enzymatic glycosilation of clotting inhibitors such as antithrombine. Antithrombin III has both an anticoagulant and an antiinflammatory effect. The anticoagulant effect appears after acting upon endothelial heparan sulfate or on the molecule of heparine, thus leading to an inhibition of thrombin. A decrease in antithrombin III levels may lead to a diminished neutralisation of thrombin and a lower activity of proteins C and S, thus inducing procoagulant consequences and increasing the susceptibility for thrombotic events. Our research tried to establish whether the levels of antithrombin III in type 2 diabetic patiens are modified, thus creating a predisposition for thrombotic events. Therefore we conducted an observational study on a sample composed of 60 patients having a diagnostic of type 2 diabetes associated with coronary artery disease, controlled with diet or with oral antidiabetics and we evaluated the levels of antithrombin III in function of the metabolic, inflammatory and coronarographic parameters. Our research showed that even though all patients were characterized by the diabetic dyslipidemia, there was no statistic relationship between antithrombin III and the lipidic fractions. As a result we cannot say that the adverse cardiac events seen in type 2 diabetic patients are influenced by the levels of antithrombin III, as a marker of an increased clotting activity.

Keywords:
Diabetes mellitus; glycated hemoglobin; fibrinolysis; thrombophilia; protein C; protein S

Issue: 2019, Volume 70, Issue 3

Pages: 1047-1052

Publication date: 2019/4/15

https://doi.org/10.37358/RC.19.3.7061

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BARARU-BOJAN, I., VLADEANU (APAVALOAIE), M.C., BOJAN, A., SIRBU, P., CIOCOIU, M., BADULESCU, O., The Role of Antithrombin III in the Pathogenesis of the Thrombotic Status in Type 2 Diabetes Mellitus, Rev. Chim., 70(3), 2019, 1047-1052.

Vancouver
Bararu-Bojan I, Vladeanu (Apavaloaie) MC, Bojan A, Sirbu P, Ciocoiu M, Badulescu O. The Role of Antithrombin III in the Pathogenesis of the Thrombotic Status in Type 2 Diabetes Mellitus. Rev. Chim.[internet]. 2019 Mar;70(3):1047-1052. Available from: https://doi.org/10.37358/RC.19.3.7061

APA 6th edition
Bararu-Bojan, I., Vladeanu (Apavaloaie), M.C., Bojan, A., Sirbu, P., Ciocoiu, M. & Badulescu, O. (2019). The Role of Antithrombin III in the Pathogenesis of the Thrombotic Status in Type 2 Diabetes Mellitus. Revista de Chimie, 70(3), 1047-1052. https://doi.org/10.37358/RC.19.3.7061

Harvard
Bararu-Bojan, I., Vladeanu (Apavaloaie), M.C., Bojan, A., Sirbu, P., Ciocoiu, M., Badulescu, O. (2019). 'The Role of Antithrombin III in the Pathogenesis of the Thrombotic Status in Type 2 Diabetes Mellitus', Revista de Chimie, 70(3), pp. 1047-1052. https://doi.org/10.37358/RC.19.3.7061

IEEE
I. Bararu-Bojan, M.C. Vladeanu(Apavaloaie), A. Bojan, P. Sirbu, M. Ciocoiu, O. Badulescu, "The Role of Antithrombin III in the Pathogenesis of the Thrombotic Status in Type 2 Diabetes Mellitus". Revista de Chimie, vol. 70, no. 3, pp. 1047-1052, 2019. [online]. https://doi.org/10.37358/RC.19.3.7061

Text
Iris Bararu-Bojan, Maria Cristina Vladeanu(Apavaloaie), Andrei Bojan, Paul-Dan Sirbu, Manuela Ciocoiu, Oana Badulescu,
The Role of Antithrombin III in the Pathogenesis of the Thrombotic Status in Type 2 Diabetes Mellitus,
Revista de Chimie,
Volume 70, Issue 3,
2019,
Pages 1047-1052,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.3.7061.
(https://revistadechimie.ro/Articles.asp?ID=7061)
Keywords: Diabetes mellitus; glycated hemoglobin; fibrinolysis; thrombophilia; protein C; protein S

RIS
TY - JOUR
T1 - The Role of Antithrombin III in the Pathogenesis of the Thrombotic Status in Type 2 Diabetes Mellitus
A1 - Bararu-Bojan, Iris
A2 - Vladeanu (Apavaloaie), Maria Cristina
A3 - Bojan, Andrei
A4 - Sirbu, Paul-Dan
A5 - Ciocoiu, Manuela
A6 - Badulescu, Oana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 3
SP - 1047
EP - 1052
UR - https://doi.org/10.37358/RC.19.3.7061
KW - Diabetes mellitus
KW - glycated hemoglobin
KW - fibrinolysis
KW - thrombophilia
KW - protein C
KW - protein S
ER -

BibTex
@article{RevCh2019P1047,
author = {Bararu-Bojan Iris and Vladeanu (Apavaloaie) Maria Cristina and Bojan Andrei and Sirbu Paul-Dan and Ciocoiu Manuela and Badulescu Oana},
title = {The Role of Antithrombin III in the Pathogenesis of the Thrombotic Status in Type 2 Diabetes Mellitus},
journal = {Revista de Chimie},
volume = {70},
number = {3},
pages = {1047-1052},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.3.7061},
url = {https://revistadechimie.ro/Articles.asp?ID=7061}
}

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