MARIA RADA, DELIA BERCEANU-VADUVA, MILAN VELIMIROVICI, SIMONA DRAGAN, DANIEL DUDA-SEIMAN, MARCEL BERCEANU-VADUVA, CORINA DUDA-SEIMAN, MARIANA TUDORAN, DANA VELIMIROVICI STUDY UPON THE SERUM LEVEL OF URIC ACID AND THE METABOLIC SYNDROME COMPONENTS The serum level of uric acid (UA) appears to be associated with a variety of cardiometabolic risk factors; however, direct association with the metabolic syndrome (MetS) remains controversial. The aim of this study is to investigate the association between serum levels of UA and the components that define MetS, differentiated by gender. 262 patients were enrolled (132 women and 130 men); mean value of the age: 58.7±16 year. Hyperuricemia was considered when the level of serum UA ³7mg/dL in men, and ³ 6mg/dL in women; MetS was defined according to the IDF criteria. The prevalence of MetS in the studied group was 35.11% and the prevalence of hyperuricemia was 16.79%. Men with hyperuricemia had the highest prevalence of abdominal obesity (87.5% vs. 66.32%, p <0.001) and hypertriglyceridemia (65.62% vs. 45.91%, p < 0.001) versus men with normal level of serum UA. Women with hyperuricemia also had a significantly higher incidence of abdominal obesity (75% vs. 57.51%, p <0.001), hypertriglyceridemia (58.33% vs. 38.33%, p <0.001), decreased HDL (50% vs. 33.33%, p <0.001) and hyperglycemia (66.66% versus 50%, p <0.001) compared to those with normal levels of serum UA. The majority of men with hyperuricemia have more than 4 of the MetS components. Hyperuricemia had a higher prevalence in patients with MetS, it may be considered as a causal factor of MetS. Elevated levels of serum uric acid were significantly more associated with the increasing number of MetS components. Early detection and treatment of hyperuricemia is essential for preventing the metabolic syndrome and its complications.