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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 4, 1245-1247

https://doi.org/10.37358/RC.19.4.7101

Dan Simion Cipu, Daniela Cipu, Delia Berceanu Vaduva, Marcel Berceanu Vaduva, Victor Dumitrascu, Matilda Radulescu, Dana Velimirovici

Biochemical, Pharmacological, and Therapeutic Effects of Triple Antihypertensive Therapy with Amlodipine, Valsartan and Hydrochlorothiazide in Elderly Hypertensive Patients with Calcium Phosphate Nephrolithiasis

Abstract:

Antihypertensives are widely prescribed in the geriatric population and could influence kidney stone risk but many aspects are still unknown. Thiazides are used to control lithogenic factors and recurrences in patients with calcium lithiasis. The aim of our study was to evaluate the relationship between essential arterial hypertension and stone disease, by studying the pharmaco-therapeutic effects of a fixed-dose combination of amlodipine + valsartan + hydrochlorothiazide (Aml + Val + HCTZ) 10/320/25 mg, on the urinary stone risk in a study group of hypertensive geriatric patients. A longitudinal, randomized, three years follow-up clinical and experimental study was conducted during June 1, 2014 - July 31, 2017. A number of 60 eligible geriatric patients, treated only with a fixed-dose combination of Aml + Val + HCTZ 10/320/25 mg, as a single-tablet, were enrolled in the study. All the patients were stone formers, with more than three episodes of crystalluria in the last two years. The patient’s age ranged between 55 and 65 years. Exclusion criteria: patients with heart failure, kidney chronic diseases, use of drugs known to affect renal function, patients with multi-morbidities. All patients had similar blood pressure values, and tension was well controlled throughout the whole study period. In the elderly patients, the treatment with 25 mg/day of hydrochlorothiazide (from the combination of Aml + Val + HCTZ 10/320/25 mg) has a beneficial and prolonged efficacy in treatment of recurrences in patients with calcium oxalate and phosphate lithiasis Our study reveals that in the elderly patients with hypertension and nephrolithiasis as a comorbidity, thiazides - 25 mg/day of hydrochlorothiazide (from the combination of Aml + Val + HCTZ 10/320/25 mg) has a beneficial effect in order to control lithogenic factors and recurrences in patients with calcium phosphate lithiasis.
Keywords:
fixed-dose combination of Aml + Val + HCTZ 10/320/25 mg; hydrochlorothiazide geriatric patient; nephrolithiasis

Issue: 2019, Volume 70, Issue 4
Pages: 1245-1247
Publication date: 2019/5/15
https://doi.org/10.37358/RC.19.4.7101
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
CIPU, D.S., CIPU, D., VADUVA, D.B., VADUVA, M.B., DUMITRASCU, V., RADULESCU, M., VELIMIROVICI, D., Biochemical, Pharmacological, and Therapeutic Effects of Triple Antihypertensive Therapy with Amlodipine, Valsartan and Hydrochlorothiazide in Elderly Hypertensive Patients with Calcium Phosphate Nephrolithiasis, Rev. Chim., 70(4), 2019, 1245-1247.

Vancouver
Cipu DS, Cipu D, Vaduva DB, Vaduva MB, Dumitrascu V, Radulescu M, Velimirovici D. Biochemical, Pharmacological, and Therapeutic Effects of Triple Antihypertensive Therapy with Amlodipine, Valsartan and Hydrochlorothiazide in Elderly Hypertensive Patients with Calcium Phosphate Nephrolithiasis. Rev. Chim.[internet]. 2019 Apr;70(4):1245-1247. Available from: https://doi.org/10.37358/RC.19.4.7101


APA 6th edition
Cipu, D.S., Cipu, D., Vaduva, D.B., Vaduva, M.B., Dumitrascu, V., Radulescu, M. & Velimirovici, D. (2019). Biochemical, Pharmacological, and Therapeutic Effects of Triple Antihypertensive Therapy with Amlodipine, Valsartan and Hydrochlorothiazide in Elderly Hypertensive Patients with Calcium Phosphate Nephrolithiasis. Revista de Chimie, 70(4), 1245-1247. https://doi.org/10.37358/RC.19.4.7101


Harvard
Cipu, D.S., Cipu, D., Vaduva, D.B., Vaduva, M.B., Dumitrascu, V., Radulescu, M., Velimirovici, D. (2019). 'Biochemical, Pharmacological, and Therapeutic Effects of Triple Antihypertensive Therapy with Amlodipine, Valsartan and Hydrochlorothiazide in Elderly Hypertensive Patients with Calcium Phosphate Nephrolithiasis', Revista de Chimie, 70(4), pp. 1245-1247. https://doi.org/10.37358/RC.19.4.7101


IEEE
D.S. Cipu, D. Cipu, D.B. Vaduva, M.B. Vaduva, V. Dumitrascu, M. Radulescu, D. Velimirovici, "Biochemical, Pharmacological, and Therapeutic Effects of Triple Antihypertensive Therapy with Amlodipine, Valsartan and Hydrochlorothiazide in Elderly Hypertensive Patients with Calcium Phosphate Nephrolithiasis". Revista de Chimie, vol. 70, no. 4, pp. 1245-1247, 2019. [online]. https://doi.org/10.37358/RC.19.4.7101


Text
Dan Simion Cipu, Daniela Cipu, Delia Berceanu Vaduva, Marcel Berceanu Vaduva, Victor Dumitrascu, Matilda Radulescu, Dana Velimirovici,
Biochemical, Pharmacological, and Therapeutic Effects of Triple Antihypertensive Therapy with Amlodipine, Valsartan and Hydrochlorothiazide in Elderly Hypertensive Patients with Calcium Phosphate Nephrolithiasis,
Revista de Chimie,
Volume 70, Issue 4,
2019,
Pages 1245-1247,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.4.7101.
(https://revistadechimie.ro/Articles.asp?ID=7101)
Keywords: fixed-dose combination of Aml + Val + HCTZ 10/320/25 mg; hydrochlorothiazide geriatric patient; nephrolithiasis


RIS
TY - JOUR
T1 - Biochemical, Pharmacological, and Therapeutic Effects of Triple Antihypertensive Therapy with Amlodipine, Valsartan and Hydrochlorothiazide in Elderly Hypertensive Patients with Calcium Phosphate Nephrolithiasis
A1 - Cipu, Dan Simion
A2 - Cipu, Daniela
A3 - Vaduva, Delia Berceanu
A4 - Vaduva, Marcel Berceanu
A5 - Dumitrascu, Victor
A6 - Radulescu, Matilda
A7 - Velimirovici, Dana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 4
SP - 1245
EP - 1247
UR - https://doi.org/10.37358/RC.19.4.7101
KW - fixed-dose combination of Aml + Val + HCTZ 10/320/25 mg
KW - hydrochlorothiazide geriatric patient
KW - nephrolithiasis
ER -


BibTex
@article{RevCh2019P1245,
author = {Cipu Dan Simion and Cipu Daniela and Vaduva Delia Berceanu and Vaduva Marcel Berceanu and Dumitrascu Victor and Radulescu Matilda and Velimirovici Dana},
title = {Biochemical, Pharmacological, and Therapeutic Effects of Triple Antihypertensive Therapy with Amlodipine, Valsartan and Hydrochlorothiazide in Elderly Hypertensive Patients with Calcium Phosphate Nephrolithiasis},
journal = {Revista de Chimie},
volume = {70},
number = {4},
pages = {1245-1247},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.4.7101},
url = {https://revistadechimie.ro/Articles.asp?ID=7101}
}
 
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