BEATRICE ROZALINA BUCA, LILIANA MITITELU-TARTAU, CRISTIANA FILIP, NINA FILIP, CIPRIAN REZUS, CRISTINA IANCU, ELENA REZUS, ALIN CONSTANTIN PINZARIU, SORIN AURELIAN PASCA, CATALINA ELENA LUPUSORU, RAOUL VASILE LUPUSORU THE INFLUENCE OF NITRIC OXID DONORS NEBIVOLOL AND S-NITROSOGLUTATHION OF THE OXIDATIVES STRESS AND LIVER FUNCTION IN RATS We aimed to investigate the influence of two nitric oxide donors on the oxidative stress and the liver function in rats with experimental-induced acute paw inflammation.The experiment was carried out on white male Wistar rats (200-250 g), randomly assigned into 4 groups of 5 animals each, which received the substances intraperitoneal, as follows: group 1 (Control) saline solution 0.1 ml/100 g body weight; group 2 (IND) indomethacin 150 mg/kg body weight (kbw); groups 3 (NEB) and 4 (GSNO) nebivolol 1 mg/kbw, respectively S-nitroso-glutathione 1 mg/kbw. Carrageenan-induced rat‘s paw edema test was used for the generation of acute inflammation. The activity of liver enzymes and of some antioxidant parameters was evaluated before the carrageenan injection, after 24 hours and 3 days. The experimental protocol was approved by the University‘s Ethic Committee on Research and Ethical Issues.The administration of indomethacin, nebivolol and S-nitroso-glutathione appears to decrease the oxidative stress after 24 h in rats with experimental-induced acute paw inflammation. The nitric oxide donors nebivolol and S-nitroso-glutathione produced moderate functional and structural liver disturbances in rats with acute inflammation.