LUCIAN HRITCU, SARA ABIDAR, GABRIELA DUMITRU, RAZVAN STEFAN BOIANGIU, MOHAMAD NHIRI, ION SANDU, ELENA TODIRASCU-CIORNEA CERATONIA SILIQUA METHANOLIC EXTRACT ON 6-OHDA ZEBRAFISH MODEL ANTIACETYLCHOLINESTERASE AND ANXIOLYTIC PROFILE
Anxiety and depression are the most common mental disorders that increase morbidity in the world, and recent data (World Health Organization - WHO) show that over 322 million people suffer from depression and anxiety, especially women being more exposed than men. 6-Hydroxydopamine (6-OHDA) is a catecholaminergic neurotoxin which is formed endogenously in patients diagnosed with Parkinson’s disease and has two mechanisms of action. Thus, it easily forms free radicals and is a potent inhibitor of the mitochondrial respiratory chain complexes I and IV. The treatments administration of 6-OHDA (160 ìM) and Ceratonia siliqua L. methanolic extract (0.1 mg/mL, 0.3 mg/mL and 1.0 mg/mL) in Danio rerio specimens affected the acetylcholinesterase activity (AChE) and anxiolytic profile in close correlation with the dose of administered extract, the group with significant differences being the treated one with 6-OHDA alone.