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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 4, 1411-1415

https://doi.org/10.37358/RC.19.4.7139

Gabriela Rusu-Zota, Daniel Vasile Timofte, Elena Albu, Petronela Nechita, Victorita Sorodoc

The Effects of Idazoxan and Efaroxan Improves Memory and Cognitive Functions in Rats Experimental research

Abstract:

Investigating the effects of idazoxan and efaroxan imidazoline receptor antagonists on cognitive functions with the rat Y-maze test; an internationally recognized experimental pattern of behavior, is to be used in order to evaluate the effects of test substances on the simple spatial memory of the laboratory animals. Our experimental evaluation tested the influence induced by idazoxan and efaroxan on the short-term memory on rats. In the experiment were used eighteen (18) male Wistar rats which were randomly divided into three groups (I - Control, II - IDZ and III - EFR) comprising of 6 animals each, treated intraperitoneally according to the following protocol: group I (Control): distilled water 0.5 mL/100 g body weight; group II (IDZ): idazoxan 3 mg/kg body weight; group III (EFR): efaroxan 1 mg/kg body weight. The purpose of this research was to assess the eligibility using the Y-maze test, involving: latency of the first arm visited, the number of arms visited, and the time spent into the arms, the number of returns of the experimental animals in the same arm, the number of alternations, percentage of spontaneous alternation. In this work, manifestations of the natural behavior of the animals tested was expressed by their choice of goal arm alternation. Statistical data processing reveals that: the administration of IDZ, as well as of EFR was accompanied by a tendency to enter a less recently visited arm and reduced the total number of arms visited, statistically significant (p[0.05) compared to control group. In this experiment, the use of these two imidazoline receptor antagonists did not considerably influence the reference memory, when pursuing the latency of the first arm visited, compared to the group treated with distilled water. The effects of IDZ and EFR on the percentage of time spent in the arms were sorted in descending order in this behavioral experimental model (IDZ]Control]EFR). The results demonstrate that the treatment with imidazoline agents optimizes the cognitive function of the animals, improving their learning ability, in the rat Y-maze Test. Regular exercise can reduce depression-, anxiety-, and impaired cognitive-like behaviors, and in conclusion these substances would be a useful pharmacological agents for the treatment of cognitive dysfunction.
Keywords:
imidazoline (I) receptor antagonists; idazoxan; efaroxan; memory

Issue: 2019, Volume 70, Issue 4
Pages: 1411-1415
Publication date: 2019/5/15
https://doi.org/10.37358/RC.19.4.7139
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
RUSU-ZOTA, G., TIMOFTE, D.V., ALBU, E., NECHITA, P., SORODOC, V., The Effects of Idazoxan and Efaroxan Improves Memory and Cognitive Functions in Rats Experimental research, Rev. Chim., 70(4), 2019, 1411-1415.

Vancouver
Rusu-Zota G, Timofte DV, Albu E, Nechita P, Sorodoc V. The Effects of Idazoxan and Efaroxan Improves Memory and Cognitive Functions in Rats Experimental research. Rev. Chim.[internet]. 2019 Apr;70(4):1411-1415. Available from: https://doi.org/10.37358/RC.19.4.7139


APA 6th edition
Rusu-Zota, G., Timofte, D.V., Albu, E., Nechita, P. & Sorodoc, V. (2019). The Effects of Idazoxan and Efaroxan Improves Memory and Cognitive Functions in Rats Experimental research. Revista de Chimie, 70(4), 1411-1415. https://doi.org/10.37358/RC.19.4.7139


Harvard
Rusu-Zota, G., Timofte, D.V., Albu, E., Nechita, P., Sorodoc, V. (2019). 'The Effects of Idazoxan and Efaroxan Improves Memory and Cognitive Functions in Rats Experimental research', Revista de Chimie, 70(4), pp. 1411-1415. https://doi.org/10.37358/RC.19.4.7139


IEEE
G. Rusu-Zota, D.V. Timofte, E. Albu, P. Nechita, V. Sorodoc, "The Effects of Idazoxan and Efaroxan Improves Memory and Cognitive Functions in Rats Experimental research". Revista de Chimie, vol. 70, no. 4, pp. 1411-1415, 2019. [online]. https://doi.org/10.37358/RC.19.4.7139


Text
Gabriela Rusu-Zota, Daniel Vasile Timofte, Elena Albu, Petronela Nechita, Victorita Sorodoc,
The Effects of Idazoxan and Efaroxan Improves Memory and Cognitive Functions in Rats Experimental research,
Revista de Chimie,
Volume 70, Issue 4,
2019,
Pages 1411-1415,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.4.7139.
(https://revistadechimie.ro/Articles.asp?ID=7139)
Keywords: imidazoline (I) receptor antagonists; idazoxan; efaroxan; memory


RIS
TY - JOUR
T1 - The Effects of Idazoxan and Efaroxan Improves Memory and Cognitive Functions in Rats Experimental research
A1 - Rusu-Zota, Gabriela
A2 - Timofte, Daniel Vasile
A3 - Albu, Elena
A4 - Nechita, Petronela
A5 - Sorodoc, Victorita
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 4
SP - 1411
EP - 1415
UR - https://doi.org/10.37358/RC.19.4.7139
KW - imidazoline (I) receptor antagonists
KW - idazoxan
KW - efaroxan
KW - memory
ER -


BibTex
@article{RevCh2019P1411,
author = {Rusu-Zota Gabriela and Timofte Daniel Vasile and Albu Elena and Nechita Petronela and Sorodoc Victorita},
title = {The Effects of Idazoxan and Efaroxan Improves Memory and Cognitive Functions in Rats Experimental research},
journal = {Revista de Chimie},
volume = {70},
number = {4},
pages = {1411-1415},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.4.7139},
url = {https://revistadechimie.ro/Articles.asp?ID=7139}
}
 
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