MARA CARSOTE, SMARANDA ADELINA PREDA, MIHAELA MITROI, ADRIAN CAMEN, LUCRETIU RADU SERUM OSTEOCALCIN, P1NP, ALKALINE PHOSPHASE, AND CROSSLAPS IN HUMANS.THE RELATIONSHIP WITH BODY MASS INDEX This is a clinical study on 56 subjects included in normal weight (NW) group (N=17), overweight (OW) group (N=19) and grade I obese (O) group (N=20), based on BMI (Body Mass Index) values: NW group had a mean BMI of 22.2 ± 2.14 kg/sqm, OW group had a BMI of 25.89 ± 1.04 kg/sqm, and O group had an average BMI of 32.2 ± 2.09 kg/sqm (p-value NW-OW, NW-O, respective OW-O groups was p<0.0005). The 3 groups were similar as age (p-value NW-OW groups = 0.7, between NW- O groups = 0.8, respective between OW - O group = 0.7). The circulating bone formation (osteocalcin, P1NP alkaline phosphatase) and resorption profile (CrossLaps) indicated no statistical significant difference between groups while the coefficient of regression r between each biochemical bone marker and BMI in every BMI group exceeded the value of p>0.05. All the 3 groups had a mean value of 25-hydroxycholecalciferol in deficiency ranges (< 30 ng/mL, normal recommended values are above 30 ng/mL) without significant differences regarding BMI groups, except for obese group when compare to the other two groups. No secondary hyperparathyroidism was associated in any group despite low vitamin D levels. Based on our observation, bone turnover biochemical markers are not influenced by BMI.
Keywords: osteocalcin, P1NP, alkaline phosphatase, menopause, bone turnover marker